Stk17b serine/threonine kinase 17b (apoptosis-inducing) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk17bprovided by MGI
Official Full Name: serine/threonine kinase 17b (apoptosis-inducing)provided by MGI
Primary source: MGI:MGI:2138162
See related: Ensembl:ENSMUSG00000026094 AllianceGenome:MGI:2138162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Drak2; 3110009A03Rik
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein autophosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in actin cytoskeleton. Predicted to be active in nucleus. Is expressed in several structures, including adrenal medulla; alimentary system; central nervous system; immune system; and testis. Orthologous to human STK17B (serine/threonine kinase 17b). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 11.6), thymus adult (RPKM 7.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 C1.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (53794671..53824374, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (53755512..53785237, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
Title: DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.
Title: Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias.
Data provide insight into the role of Drak2 in autoimmune diseases by showing that Drak2 may not suppress TGF-beta signaling in T cells, and therefore may contribute to autoimmune disease via other molecular pathways.
Title: Drak2 Does Not Regulate TGF-β Signaling in T Cells.
does not function as an essential tumor suppressor or tumor surveillance protein
Title: Drak2 is not required for tumor surveillance and suppression.
results demonstrate that DRAK2 plays an important role in primary and memory T cell responsiveness to allografts
Title: Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses.
DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation.
Title: Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
p70S6 kinase was a bona fide Drak2 substrate
Title: Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation.
Drak2 overexpression led to aggravated beta-cell apoptosis triggered by free fatty acids (FFA) by compromising the increase of anti-apoptotic factors, such as Bcl-2, Bcl-xL and Flip, upon FFA assault
Title: Drak2 overexpression results in increased beta-cell apoptosis after free fatty acid stimulation.
DRAK2 blockade may lead to permanent autoimmune T cell destruction via intrinsic apoptosis pathways.
Title: Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity.
Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease
Title: Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498358 (e-PCR)
- UniSTS:498358

Stk17b (e-PCR), detects polymorphism
- UniSTS:498358

RH135901 (e-PCR)
- UniSTS:209899

Homology

Homologs of the Stk17b gene: The Stk17b gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and fruit fly.
Orthologs from Annotation Pipeline: 479 organisms have orthologs with human gene Stk17b
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase 17B

Names: DAP kinase-related apoptosis-inducing protein kinase 2

NP_598571.2

EC 2.7.11.1

XP_006496422.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133810.3 → NP_598571.2 serine/threonine-protein kinase 17B

See identical proteins and their annotated locations for NP_598571.2

Status: VALIDATED

Source sequence(s)

AK165291, AY092028, BY034689

Consensus CDS

CCDS14955.1

UniProtKB/Swiss-Prot

Q8BG48, Q923E7

Related

ENSMUSP00000027263.8, ENSMUST00000027263.14

Conserved Domains (2) summary

smart00220
Location:37 → 293

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14198
Location:24 → 293

STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

53794671..53824374 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496359.5 → XP_006496422.1 serine/threonine-protein kinase 17B isoform X1

Conserved Domains (1) summary

cl21453
Location:1 → 165

PKc_like; Protein Kinases, catalytic domain