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RAB11B RAB11B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 9230, updated on 6-Sep-2021

Summary

Official Symbol
RAB11Bprovided by HGNC
Official Full Name
RAB11B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9761
See related
Ensembl:ENSG00000185236 MIM:604198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H-YPT3; NDAGSCW
Summary
The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in fat (RPKM 36.5), thyroid (RPKM 36.2) and 25 other tissues See more
Orthologs
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Genomic context

See RAB11B in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8390360..8404434)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8455244..8469318)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene angiopoietin like 4 Neighboring gene RAB11B antisense RNA 1 Neighboring gene microRNA 4999 Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene heterogeneous nuclear ribonucleoprotein M

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
nef HIV-1 Nef co-localization with Rab11A GTPase is revealed by staining in the peripheral and perinuclear compartments PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133246

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding HDA PubMed 
enables myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance by transcytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in constitutive secretory pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in constitutive secretory pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in melanosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor recycling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of anion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transferrin transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in anchored component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in recycling endosome membrane TAS
Traceable Author Statement
more info
 
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras-related protein Rab-11B
Names
GTP-binding protein YPT3
RAB11B, member of RAS oncogene family
NP_004209.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004218.4NP_004209.2  ras-related protein Rab-11B

    See identical proteins and their annotated locations for NP_004209.2

    Status: VALIDATED

    Source sequence(s)
    AC136469
    Consensus CDS
    CCDS12201.1
    UniProtKB/Swiss-Prot
    Q15907
    Related
    ENSP00000333547.5, ENST00000328024.11
    Conserved Domains (1) summary
    cd01868
    Location:9173
    Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    8390360..8404434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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