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Rab11b RAB11B, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19326, updated on 20-Feb-2024

Summary

Official Symbol
Rab11bprovided by MGI
Official Full Name
RAB11B, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:99425
See related
Ensembl:ENSMUSG00000077450 AllianceGenome:MGI:99425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730055L17Rik
Summary
Enables GTP binding activity and GTPase activity. Involved in several processes, including melanosome transport; protein transport; and regulation of endocytic recycling. Located in recycling endosome membrane. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; limb; and liver. Orthologous to human RAB11B (RAB11B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 49.8), adrenal adult (RPKM 49.3) and 28 other tissues See more
Orthologs
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Genomic context

See Rab11b in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33961458..33979460, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33742484..33760486, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene STARR-positive B cell enhancer ABC_E10946 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7520 Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1 Neighboring gene angiopoietin-like 4 Neighboring gene predicted gene, 53997 Neighboring gene STARR-seq mESC enhancer starr_42411 Neighboring gene STARR-positive B cell enhancer ABC_E956 Neighboring gene KN motif and ankyrin repeat domains 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance by transcytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
involved_in constitutive secretory pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in constitutive secretory pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of monoatomic anion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in transferrin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ras-related protein Rab-11B
Names
RAS oncogene family protein
NP_033023.1
XP_006523950.1
XP_030105459.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008997.3NP_033023.1  ras-related protein Rab-11B

    See identical proteins and their annotated locations for NP_033023.1

    Status: VALIDATED

    Source sequence(s)
    AK036482, AK043096, AK146623, BM935109, BU705914, BY275360
    Consensus CDS
    CCDS28628.1
    UniProtKB/Swiss-Prot
    P46638
    UniProtKB/TrEMBL
    G3UZD3, Q78ZJ8
    Related
    ENSMUSP00000110021.5, ENSMUST00000057373.14
    Conserved Domains (2) summary
    PLN03110
    Location:5217
    PLN03110; Rab GTPase; Provisional
    cd01868
    Location:9173
    Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33961458..33979460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249599.2XP_030105459.1  ras-related protein Rab-11B isoform X1

    Conserved Domains (1) summary
    cd01868
    Location:74233
    Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
  2. XM_006523887.5XP_006523950.1  ras-related protein Rab-11B isoform X2

    See identical proteins and their annotated locations for XP_006523950.1

    UniProtKB/TrEMBL
    G3UZD3
    Related
    ENSMUSP00000134448.2, ENSMUST00000173860.8
    Conserved Domains (1) summary
    cd01868
    Location:2160
    Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25