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MTA2 metastasis associated 1 family member 2 [ Homo sapiens (human) ]

Gene ID: 9219, updated on 7-Jun-2020

Summary

Official Symbol
MTA2provided by HGNC
Official Full Name
metastasis associated 1 family member 2provided by HGNC
Primary source
HGNC:HGNC:7411
See related
Ensembl:ENSG00000149480 MIM:603947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PID; MTA1L1
Summary
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in lymph node (RPKM 29.2), skin (RPKM 28.1) and 25 other tissues See more
Orthologs

Genomic context

See MTA2 in Genome Data Viewer
Location:
11q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62593214..62601865, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62360675..62369312, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene microRNA 6747 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene EMAP like 3 Neighboring gene retinal outer segment membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr weakly interacts with MTA-2 in yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686F2281

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to nucleosomal DNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP-dependent chromatin remodeling HDA PubMed 
DNA methylation IEA
Inferred from Electronic Annotation
more info
 
chromatin assembly or disassembly TAS
Traceable Author Statement
more info
PubMed 
histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase complex TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
nuclear chromatin HDA PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex HDA PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metastasis-associated protein MTA2
Names
MTA1-L1 protein
metastasis -associated gene 1-like 1
metastasis associated gene family, member 2
metastasis-associated 1-like 1
metastasis-associated protein 2
p53 target protein in deacetylase complex

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330292.2NP_001317221.1  metastasis-associated protein MTA2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK301569, BC053650, BF590712, CR975270
    Consensus CDS
    CCDS81576.1
    UniProtKB/Swiss-Prot
    O94776
    Related
    ENSP00000431797.1, ENST00000527204.5
    Conserved Domains (3) summary
    cd11661
    Location:94139
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:190241
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:125
    ELM2; ELM2 domain
  2. NM_004739.4NP_004730.2  metastasis-associated protein MTA2 isoform 1

    See identical proteins and their annotated locations for NP_004730.2

    Status: REVIEWED

    Source sequence(s)
    AI380395, AL561056, AP001458, BC053650, BQ574987
    Consensus CDS
    CCDS8022.1
    UniProtKB/Swiss-Prot
    O94776
    UniProtKB/TrEMBL
    A0A024R534
    Related
    ENSP00000278823.2, ENST00000278823.7
    Conserved Domains (5) summary
    cd11661
    Location:267312
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:363414
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3168
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:147198
    ELM2; ELM2 domain
    cl26464
    Location:405664
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62593214..62601865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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