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MTA2 metastasis associated 1 family member 2 [ Homo sapiens (human) ]

Gene ID: 9219, updated on 6-Oct-2024

Summary

Official Symbol
MTA2provided by HGNC
Official Full Name
metastasis associated 1 family member 2provided by HGNC
Primary source
HGNC:HGNC:7411
See related
Ensembl:ENSG00000149480 MIM:603947; AllianceGenome:HGNC:7411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PID; MTA1L1
Summary
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in lymph node (RPKM 29.2), skin (RPKM 28.1) and 25 other tissues See more
Orthologs
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Genomic context

See MTA2 in Genome Data Viewer
Location:
11q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62593214..62601865, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62582662..62591313, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62360686..62369337, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene microRNA 6747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62341487-62342448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62342449-62343410 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62358805-62359500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4828 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62368208-62368918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62370341-62371050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4831 Neighboring gene EMAP like 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62378772-62379330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62379331-62379890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4832 Neighboring gene retinal outer segment membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr weakly interacts with MTA-2 in yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp686F2281

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to nucleosomal DNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromatin HDA PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone deacetylase complex TAS
Traceable Author Statement
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex HDA PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metastasis-associated protein MTA2
Names
MTA1-L1 protein
metastasis -associated gene 1-like 1
metastasis associated gene family, member 2
metastasis-associated 1-like 1
metastasis-associated protein 2
p53 target protein in deacetylase complex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330292.2NP_001317221.1  metastasis-associated protein MTA2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK301569, BC053650, BF590712, CR975270
    Consensus CDS
    CCDS81576.1
    UniProtKB/Swiss-Prot
    O94776
    Related
    ENSP00000431797.1, ENST00000527204.5
    Conserved Domains (4) summary
    cd11661
    Location:94139
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:190241
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:125
    ELM2; ELM2 domain
    pfam17226
    Location:276351
    MTA_R1; MTA R1 domain
  2. NM_004739.4NP_004730.2  metastasis-associated protein MTA2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AI380395, AL561056, AP001458, BC053650, BQ574987
    Consensus CDS
    CCDS8022.1
    UniProtKB/Swiss-Prot
    O94776, Q68DB1, Q9UQB5
    Related
    ENSP00000278823.2, ENST00000278823.7
    Conserved Domains (5) summary
    cd11661
    Location:267312
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:363414
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3168
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:147198
    ELM2; ELM2 domain
    cl26464
    Location:405664
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62593214..62601865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62582662..62591313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)