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Mta2 metastasis-associated gene family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 23942, updated on 8-Dec-2022

Summary

Official Symbol
Mta2provided by MGI
Official Full Name
metastasis-associated gene family, member 2provided by MGI
Primary source
MGI:MGI:1346340
See related
Ensembl:ENSMUSG00000071646 AllianceGenome:MGI:1346340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mmta2; Mta1l1; Mata1l1
Summary
Enables histone deacetylase activity and transcription coregulator activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within DNA methylation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Used to study systemic lupus erythematosus. Orthologous to human MTA2 (metastasis associated 1 family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 21.3), CNS E11.5 (RPKM 18.5) and 28 other tissues See more
Orthologs
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Genomic context

See Mta2 in Genome Data Viewer
Location:
19; 19 A
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8919284..8929664)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8941920..8952300)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36629 Neighboring gene beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) Neighboring gene echinoderm microtubule associated protein like 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene eukaryotic translation elongation factor 1 gamma

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin remodeling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within chromosome organization TAS
Traceable Author Statement
more info
PubMed 
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell fate specification NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stem cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NuRD complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
part_of histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metastasis-associated protein MTA2
Names
metastais-associated gene family, member 2
metastasis-associated 1-like 1
metastasis-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412946.1NP_001399875.1  metastasis-associated protein MTA2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129217, AC130819
  2. NM_001412948.1NP_001399877.1  metastasis-associated protein MTA2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129217, AC130819
  3. NM_011842.4NP_035972.3  metastasis-associated protein MTA2 isoform 1

    See identical proteins and their annotated locations for NP_035972.3

    Status: VALIDATED

    Source sequence(s)
    AC129217, AC130819
    Consensus CDS
    CCDS29561.1
    UniProtKB/Swiss-Prot
    Q3TVT8, Q9R190
    Related
    ENSMUSP00000093959.3, ENSMUST00000096240.3
    Conserved Domains (6) summary
    smart00717
    Location:266313
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:267312
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:363413
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:366421
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3168
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:147198
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8919284..8929664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250933.2XP_030106793.1  metastasis-associated protein MTA2 isoform X1

    Conserved Domains (4) summary
    cd11661
    Location:94139
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:190240
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:125
    ELM2; ELM2 domain
    pfam17226
    Location:276351
    MTA_R1; MTA R1 domain
  2. XM_030250932.2XP_030106792.1  metastasis-associated protein MTA2 isoform X1

    Conserved Domains (4) summary
    cd11661
    Location:94139
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:190240
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:125
    ELM2; ELM2 domain
    pfam17226
    Location:276351
    MTA_R1; MTA R1 domain