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AURKB aurora kinase B [ Homo sapiens (human) ]

Gene ID: 9212, updated on 3-Dec-2023

Summary

Official Symbol
AURKBprovided by HGNC
Official Full Name
aurora kinase Bprovided by HGNC
Primary source
HGNC:HGNC:11390
See related
Ensembl:ENSG00000178999 MIM:604970; AllianceGenome:HGNC:11390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
Summary
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in lymph node (RPKM 11.6), bone marrow (RPKM 10.7) and 11 other tissues See more
Orthologs
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Genomic context

See AURKB in Genome Data Viewer
Location:
17p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8204731..8210575, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8110914..8116765, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8108049..8113893, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8092665-8093311 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8093312-8093957 Neighboring gene uncharacterized LOC124903913 Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11683 Neighboring gene nonconserved acetylation island sequence 72 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8107017-8107517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8113125-8113784 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:8124016-8124902 Neighboring gene tRNA-Trp (anticodon CCA) 1-1 Neighboring gene long intergenic non-protein coding RNA 324 Neighboring gene tRNA-Gly (anticodon TCC) 3-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates AURKB in HeLa cells within 12 hours of exposure PubMed
vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
NOT enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in abscission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
PubMed 
involved_in cell cycle G2/M phase transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cleavage furrow formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone modification TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic cytokinesis checkpoint signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle midzone assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic spindle midzone assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cGAS/STING signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokinesis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of mitotic cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of mitotic sister chromatid segregation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mitotic sister chromatid separation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-translational protein modification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of chromosome segregation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
involved_in spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromocenter IEA
Inferred from Electronic Annotation
more info
 
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromosome passenger complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of chromosome passenger complex TAS
Traceable Author Statement
more info
PubMed 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody TAS
Traceable Author Statement
more info
PubMed 
located_in mitotic spindle midzone IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle pole IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle TAS
Traceable Author Statement
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
aurora kinase B
Names
aurora kinase B-Sv1
aurora kinase B-Sv2
aurora- and Ipl1-like midbody-associated protein 1
aurora- and Ipl1-like midbody-associated protein 1 homolog
aurora-1
aurora-B
aurora-related kinase 2
aurora/IPL1-related kinase 2
protein phosphatase 1, regulatory subunit 48
serine/threonine kinase 12
serine/threonine-protein kinase 12
serine/threonine-protein kinase 5
serine/threonine-protein kinase aurora-B
NP_001243763.1
NP_001271455.1
NP_001300879.1
NP_001300880.1
NP_001300881.1
NP_001300882.1
NP_001300883.1
NP_001300884.1
NP_004208.2
XP_011522374.1
XP_016880800.1
XP_047293006.1
XP_047293007.1
XP_054173751.1
XP_054173752.1
XP_054173753.1
XP_054173754.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256834.3NP_001243763.1  aurora kinase B isoform 2

    See identical proteins and their annotated locations for NP_001243763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AK297976, BC009751
    Consensus CDS
    CCDS58514.1
    UniProtKB/TrEMBL
    B2RC06
    Related
    ENSP00000443869.1, ENST00000534871.5
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001284526.2NP_001271455.1  aurora kinase B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site in the mid-coding region compared to variant 1. The resulting isoform (3) is one amino acid longer than isoform 1.
    Source sequence(s)
    BC009751, BC013300
    Consensus CDS
    CCDS67162.1
    UniProtKB/TrEMBL
    B2RC06
    Related
    ENSP00000313950.6, ENST00000316199.10
    Conserved Domains (2) summary
    smart00220
    Location:78328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:71340
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001313950.2NP_001300879.1  aurora kinase B isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 4 and 1 encode the same isoform (1).
    Source sequence(s)
    BC009751, BP225027, CX781462
    Consensus CDS
    CCDS11134.1
    UniProtKB/Swiss-Prot
    B4DNM4, C7G533, C7G534, C7G535, D3DTR4, J9JID1, O14630, O60446, O95083, Q96DV5, Q96GD4, Q9UQ46
    UniProtKB/TrEMBL
    B2RC06
    Conserved Domains (1) summary
    cl21453
    Location:70339
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001313951.1NP_001300880.1  aurora kinase B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a novel exon in the 5' region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. Variants 5 and 2 encode the same isoform (2).
    Source sequence(s)
    BC009751, BE797606, BP225027
    Consensus CDS
    CCDS58514.1
    UniProtKB/TrEMBL
    B2RC06
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001313952.2NP_001300881.1  aurora kinase B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' coding region and uses two alternate acceptor splice sites in the mid-region compared to variant 1. The encoded isoform (4), resulting from use of an in-frame downstream start codon, has a shorter N-terminus and and an extra amino acid in the mid-region compared to isoform 1.
    Source sequence(s)
    BC009751, BM905813, BP225027
    UniProtKB/TrEMBL
    B2RC06
    Conserved Domains (2) summary
    smart00220
    Location:37287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:30299
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001313953.3NP_001300882.1  aurora kinase B isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses alternate in-frame donor and acceptor splices sites in the mid-coding region compared to variant 1. The resulting isoform (5) is shorter containing a 16 aa protein segment not found in isoform 1.
    Source sequence(s)
    AC135178, BC009751, BU153790
    Consensus CDS
    CCDS82065.1
    UniProtKB/TrEMBL
    B2RC06
    Related
    ENSP00000462207.1, ENST00000578549.5
    Conserved Domains (2) summary
    smart00220
    Location:102295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70307
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001313954.2NP_001300883.1  aurora kinase B isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate donor splice site in the mid-region compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (6) that is shorter, with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF004022, BC009751, BP225027, BU181480
    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:27175
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:21187
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001313955.2NP_001300884.1  aurora kinase B isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks two non-consecutive exons in the 5' and mid-region and uses an alternate donor splice site in the mid-region, compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (7) that is shorter, with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC009751, BI199088, BP225027
    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:10159
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:10171
    PKc_like; Protein Kinases, catalytic domain
  9. NM_004217.4NP_004208.2  aurora kinase B isoform 1

    See identical proteins and their annotated locations for NP_004208.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the predominant isoform (1). Variants 1 and 4 encode the same isoform.
    Source sequence(s)
    AC135178, BC000442, BC009751
    Consensus CDS
    CCDS11134.1
    UniProtKB/Swiss-Prot
    B4DNM4, C7G533, C7G534, C7G535, D3DTR4, J9JID1, O14630, O60446, O95083, Q96DV5, Q96GD4, Q9UQ46
    UniProtKB/TrEMBL
    B2RC06
    Related
    ENSP00000463999.1, ENST00000585124.6
    Conserved Domains (1) summary
    cl21453
    Location:70339
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_132730.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate donor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC009751, CN286704
  2. NR_132731.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an internal exon and uses an alternate acceptor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY677083, BC009751

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8204731..8210575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437051.1XP_047293007.1  aurora kinase B isoform X2

  2. XM_011524072.4XP_011522374.1  aurora kinase B isoform X1

    See identical proteins and their annotated locations for XP_011522374.1

    UniProtKB/TrEMBL
    B2RC06
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  3. XM_047437050.1XP_047293006.1  aurora kinase B isoform X1

    UniProtKB/TrEMBL
    B2RC06
  4. XM_017025311.2XP_016880800.1  aurora kinase B isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:27175
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:21187
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8110914..8116765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317778.1XP_054173753.1  aurora kinase B isoform X2

  2. XM_054317776.1XP_054173751.1  aurora kinase B isoform X1

    UniProtKB/TrEMBL
    B2RC06
  3. XM_054317777.1XP_054173752.1  aurora kinase B isoform X1

    UniProtKB/TrEMBL
    B2RC06
  4. XM_054317779.1XP_054173754.1  aurora kinase B isoform X3