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AURKB aurora kinase B [ Homo sapiens (human) ]

Gene ID: 9212, updated on 9-Dec-2018

Summary

Official Symbol
AURKBprovided by HGNC
Official Full Name
aurora kinase Bprovided by HGNC
Primary source
HGNC:HGNC:11390
See related
Ensembl:ENSG00000178999 MIM:604970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; ARK-2; STK-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
Summary
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in lymph node (RPKM 11.6), bone marrow (RPKM 10.7) and 11 other tissues See more
Orthologs

Genomic context

See AURKB in Genome Data Viewer
Location:
17p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (8204731..8210767, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8108049..8113944, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene nonconserved acetylation island sequence 72 enhancer Neighboring gene transfer RNA-Trp (CCA) 1-1 Neighboring gene long intergenic non-protein coding RNA 324 Neighboring gene tRNA-Gly (TCC) 3-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates AURKB in HeLa cells within 12 hours of exposure PubMed
vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
    APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
  • ATM Signaling Network in Development and Disease, organism-specific biosystem (from WikiPathways)
    ATM Signaling Network in Development and Disease, organism-specific biosystemThis pathway is modeled after Figure 4 in the article "The ATM signaling network in development and disease" (See Bibliography). When DNA is damaged, DDR begins to work on recuperating the damage th...
  • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora A signaling, organism-specific biosystem
    Aurora A signaling
  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • Aurora C signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora C signaling, organism-specific biosystem
    Aurora C signaling
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    FOXM1 transcription factor network, organism-specific biosystem
    FOXM1 transcription factor network
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
    RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
  • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
    Regulation of mitotic cell cycle, organism-specific biosystem
    Regulation of mitotic cell cycle
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • SUMO E3 ligases SUMOylate target proteins, organism-specific biosystem (from REACTOME)
    SUMO E3 ligases SUMOylate target proteins, organism-specific biosystemSUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro ...
  • SUMOylation, organism-specific biosystem (from REACTOME)
    SUMOylation, organism-specific biosystemSmall Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Ha...
  • SUMOylation of DNA replication proteins, organism-specific biosystem (from REACTOME)
    SUMOylation of DNA replication proteins, organism-specific biosystemThe sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-str...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Aurora kinases, organism-specific biosystem (from Pathway Interaction Database)
    Signaling by Aurora kinases, organism-specific biosystem
    Signaling by Aurora kinases
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone serine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
abscission ISS
Inferred from Sequence or Structural Similarity
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow formation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-S28 phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
histone modification TAS
Traceable Author Statement
more info
PubMed 
mitotic cytokinesis checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic spindle assembly checkpoint IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle midzone assembly TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokinesis TAS
Traceable Author Statement
more info
PubMed 
positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of chromosome segregation TAS
Traceable Author Statement
more info
PubMed 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromocenter IEA
Inferred from Electronic Annotation
more info
 
chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome passenger complex IPI
Inferred from Physical Interaction
more info
PubMed 
chromosome passenger complex TAS
Traceable Author Statement
more info
PubMed 
condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
condensed nuclear chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
midbody TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle midzone IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle TAS
Traceable Author Statement
more info
PubMed 
spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
aurora kinase B
Names
aurora kinase B-Sv1
aurora kinase B-Sv2
aurora- and Ipl1-like midbody-associated protein 1
aurora-1
aurora-B
aurora-related kinase 2
aurora/IPL1-related kinase 2
protein phosphatase 1, regulatory subunit 48
serine/threonine kinase 12
serine/threonine-protein kinase 12
serine/threonine-protein kinase 5
serine/threonine-protein kinase aurora-B
NP_001243763.1
NP_001271455.1
NP_001300879.1
NP_001300880.1
NP_001300881.1
NP_001300882.1
NP_001300883.1
NP_001300884.1
NP_004208.2
XP_011522374.1
XP_016880796.1
XP_016880797.1
XP_016880798.1
XP_016880799.1
XP_016880800.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256834.2NP_001243763.1  aurora kinase B isoform 2

    See identical proteins and their annotated locations for NP_001243763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AK297976, BC009751, BE514591, BP225027
    Consensus CDS
    CCDS58514.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000443869.1, ENST00000534871.5
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001284526.1NP_001271455.1  aurora kinase B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site in the mid-coding region compared to variant 1. The resulting isoform (3) is one amino acid longer than isoform 1.
    Source sequence(s)
    BC009751, BC013300, BE514591, BP225027
    Consensus CDS
    CCDS67162.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000313950.6, ENST00000316199.10
    Conserved Domains (2) summary
    smart00220
    Location:78328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:71340
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001313950.1NP_001300879.1  aurora kinase B isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 4 and 1 encode the same isoform (1).
    Source sequence(s)
    BC009751, BE514591, BP225027, CX781462
    Consensus CDS
    CCDS11134.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (1) summary
    cl21453
    Location:70339
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001313951.1NP_001300880.1  aurora kinase B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a novel exon in the 5' region, which results in translation initiation from an in-frame downstream start codon compared to variant 1. Variants 5 and 2 encode the same isoform (2).
    Source sequence(s)
    BC009751, BE797606, BP225027
    Consensus CDS
    CCDS58514.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001313952.1NP_001300881.1  aurora kinase B isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' coding region and uses two alternate acceptor splice sites in the mid-region compared to variant 1. The encoded isoform (4), resulting from use of an in-frame downstream start codon, has a shorter N-terminus and and an extra amino acid in the mid-region compared to isoform 1.
    Source sequence(s)
    BC009751, BE514591, BM905813, BP225027
    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:37287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:30299
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001313953.2NP_001300882.1  aurora kinase B isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses alternate in-frame donor and acceptor splices sites in the mid-coding region compared to variant 1. The resulting isoform (5) is shorter containing a 16 aa protein segment not found in isoform 1.
    Source sequence(s)
    AC135178, BC009751, BU153790
    Consensus CDS
    CCDS82065.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000462207.1, ENST00000578549.5
    Conserved Domains (2) summary
    smart00220
    Location:102295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70307
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001313954.1NP_001300883.1  aurora kinase B isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate donor splice site in the mid-region compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (6) that is shorter, with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF004022, BC009751, BE514591, BP225027, BU181480
    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:27175
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:21187
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001313955.1NP_001300884.1  aurora kinase B isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks two non-consecutive exons in the 5' and mid-region and uses an alternate donor splice site in the mid-region, compared to variant 1. It represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render this transcript variant a candidate for nonsense-mediated mRNA decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, which would result in an isoform (7) that is shorter, with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BC009751, BE514591, BI199088, BP225027
    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:10159
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:10171
    PKc_like; Protein Kinases, catalytic domain
  9. NM_004217.4NP_004208.2  aurora kinase B isoform 1

    See identical proteins and their annotated locations for NP_004208.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the predominant isoform (1). Variants 1 and 4 encode the same isoform.
    Source sequence(s)
    AC135178, BC000442, BC009751
    Consensus CDS
    CCDS11134.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000463999.1, ENST00000585124.5
    Conserved Domains (1) summary
    cl21453
    Location:70339
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_132730.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate donor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC009751, BE514591, BP225027, CN286704
  2. NR_132731.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an internal exon and uses an alternate acceptor splice site in the mid-region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript variant a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY677083, BC009751

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    8204731..8210767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025307.2XP_016880796.1  aurora kinase B isoform X1

    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017025308.2XP_016880797.1  aurora kinase B isoform X2

  3. XM_011524072.3XP_011522374.1  aurora kinase B isoform X1

    See identical proteins and their annotated locations for XP_011522374.1

    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017025310.1XP_016880799.1  aurora kinase B isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:27175
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:21187
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017025309.1XP_016880798.1  aurora kinase B isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:27175
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:21187
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017025311.1XP_016880800.1  aurora kinase B isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:27175
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:21187
    PKc_like; Protein Kinases, catalytic domain
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