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Aurkb aurora kinase B [ Mus musculus (house mouse) ]

Gene ID: 20877, updated on 17-Jul-2024

Summary

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Official Symbol
Aurkbprovided by MGI
Official Full Name
aurora kinase Bprovided by MGI
Primary source
MGI:MGI:107168
See related
Ensembl:ENSMUSG00000020897 AllianceGenome:MGI:107168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aik2; Aim1; Ark2; AurB; IPL1; Stk5; AIM-1; AIRK2; STK-1; Stk12
Summary
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]
Expression
Broad expression in thymus adult (RPKM 36.3), liver E14.5 (RPKM 33.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Aurkb in Genome Data Viewer
Location:
11 B3; 11 42.32 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68936477..68942490)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69045624..69051664)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3961 Neighboring gene STARR-positive B cell enhancer ABC_E2357 Neighboring gene nuclear encoded tRNA glycine 6 (anticodon TCC) Neighboring gene nuclear encoded tRNA trytophan 7 (anticodon CCA) Neighboring gene STARR-positive B cell enhancer ABC_E3962 Neighboring gene STARR-positive B cell enhancer ABC_E5237 Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene STARR-positive B cell enhancer ABC_E7002 Neighboring gene nuclear encoded tRNA isoleucine 4 (anticodon AAT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An analog-sensitive allele of Aurora kinase B is lethal in mouse. Vazquez BN, et al. MicroPubl Biol, 2021. PMID 34841221, Free PMC Article
  2. Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B. Blengini CS, et al. Aging Cell, 2021 Nov. PMID 34704342, Free PMC Article
  3. Salivary glands require Aurora Kinase B for regeneration after transient innate immune-mediated injury. Shaalan A, et al. Sci Rep, 2019 Aug 5. PMID 31383943, Free PMC Article
  4. Aurora B prevents aneuploidy via MAD2 during the first mitotic cleavage in oxidatively damaged embryos. Li J, et al. Cell Prolif, 2019 Sep. PMID 31264311, Free PMC Article
  5. Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia. Alferez DG, et al. Int J Oncol, 2012 Oct. PMID 22858681

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
    Title: Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
  2. Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus.
    Title: Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus.
  3. Haspin participates in AURKB recruitment to centromeres and contributes to chromosome congression in male mouse meiosis.
    Title: Haspin participates in AURKB recruitment to centromeres and contributes to chromosome congression in male mouse meiosis.
  4. CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
    Title: CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
  5. Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.
    Title: Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.
  6. Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
    Title: Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
  7. Adhesion-growth factor crosstalk regulates AURKB activation and ERK signalling in re-adherent fibroblasts.
    Title: Adhesion-growth factor crosstalk regulates AURKB activation and ERK signalling in re-adherent fibroblasts.
  8. High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
    Title: High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
  9. A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells.
    Title: A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells.
  10. Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
    Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (10)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle midzone assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle midzone assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic sister chromatid separation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromocenter IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromosome passenger complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromosome passenger complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle pole ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
aurora kinase B
Names
ARK-2
aurora 1
aurora B
aurora- and IPL1-like midbody-associated protein 1
aurora-related kinase 2
aurora/IPL1-related kinase 2
serine/threonine kinase 12
serine/threonine kinase 5
serine/threonine-protein kinase 12
serine/threonine-protein kinase 5
serine/threonine-protein kinase aurora-B
NP_001412359.1
NP_001412360.1
NP_001412361.1
NP_001412362.1
NP_035626.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425430.1 → NP_001412359.1  aurora kinase B isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL645902

  2. NM_001425431.1 → NP_001412360.1  aurora kinase B isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL645902

  3. NM_001425432.1 → NP_001412361.1  aurora kinase B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL645902

  4. NM_001425433.1 → NP_001412362.1  aurora kinase B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL645902

  5. NM_011496.3 → NP_035626.1  aurora kinase B isoform 1

    See identical proteins and their annotated locations for NP_035626.1

    Status: REVIEWED

    Source sequence(s)
    AL645902
    Consensus CDS
    CCDS24877.1
    UniProtKB/Swiss-Prot
    O70126, Q61882, Q8C6C1
    Related
    ENSMUSP00000021277.6, ENSMUST00000021277.6
    Conserved Domains (2) summary
    smart00220
    Location:82 → 332
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:77 → 344
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68936477..68942490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70126.2 GenPept UniProtKB/Swiss-Prot:O70126

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