Aurkb aurora kinase B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aurkbprovided by MGI
Official Full Name: aurora kinase Bprovided by MGI
Primary source: MGI:MGI:107168
See related: Ensembl:ENSMUSG00000020897 AllianceGenome:MGI:107168
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aik2; Aim1; Ark2; AurB; IPL1; Stk5; AIM-1; AIRK2; STK-1; Stk12
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]
Expression: Broad expression in thymus adult (RPKM 36.3), liver E14.5 (RPKM 33.6) and 19 other tissues See more
Orthologs: all
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Genomic context

Location:: 11 B3; 11 42.32 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (68936477..68942490)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69045624..69051664)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
Title: Aurora kinase B disruption suppresses pathological retinal angiogenesis by affecting cell cycle progression.
Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus.
Title: Effect of Aurora kinase B on polyploidy and decidualization in mouse uterus.
Haspin participates in AURKB recruitment to centromeres and contributes to chromosome congression in male mouse meiosis.
Title: Haspin participates in AURKB recruitment to centromeres and contributes to chromosome congression in male mouse meiosis.
CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
Title: CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.
Title: Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.
Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
Title: Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes.
Adhesion-growth factor crosstalk regulates AURKB activation and ERK signalling in re-adherent fibroblasts.
Title: Adhesion-growth factor crosstalk regulates AURKB activation and ERK signalling in re-adherent fibroblasts.
High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
Title: High-throughput kinase inhibitor screening reveals roles for Aurora and Nuak kinases in neurite initiation and dendritic branching.
A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells.
Title: A functional genetic screen identifies aurora kinase b as an essential regulator of Sox9-positive mouse embryonic lung progenitor cells.
Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Title: Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129726 (e-PCR)
- UniSTS:213021

Aurkb (e-PCR), detects polymorphism
- UniSTS:265048

Stk5 (e-PCR), detects polymorphism
- UniSTS:144520

RH125386 (e-PCR)
- UniSTS:162208

Aurkb (e-PCR), detects polymorphism
- UniSTS:527269

Tk1 (e-PCR), detects polymorphism
- UniSTS:531386

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H1-4S27 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H1-4S27 kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H3S28 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cleavage furrow formation	IEA Inferred from Electronic Annotation more info
involved_in cleavage furrow formation	ISO Inferred from Sequence Orthology more info
involved_in cleavage furrow formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in midbody abscission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid biorientation	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid biorientation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid biorientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle midzone assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle midzone assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle midzone assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle midzone assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of B cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of B cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cGAS/STING signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to chromatin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic sister chromatid segregation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic sister chromatid separation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in repair of mitotic kinetochore microtubule attachment defect	IEA Inferred from Electronic Annotation more info
involved_in repair of mitotic kinetochore microtubule attachment defect	ISO Inferred from Sequence Orthology more info
involved_in repair of mitotic kinetochore microtubule attachment defect	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle organization	IEA Inferred from Electronic Annotation more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in chromatin	IEA Inferred from Electronic Annotation more info
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	IDA Inferred from Direct Assay more info	PubMed
part_of chromosome passenger complex	IEA Inferred from Electronic Annotation more info
part_of chromosome passenger complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aurora kinase B

Names: ARK-2; aurora 1; aurora B; aurora- and IPL1-like midbody-associated protein 1; aurora-related kinase 2; aurora/IPL1-related kinase 2; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B

NP_001412359.1

EC 2.7.11.1

NP_001412360.1

EC 2.7.11.1

NP_001412361.1

EC 2.7.11.1

NP_001412362.1

EC 2.7.11.1

NP_035626.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001425430.1 → NP_001412359.1 aurora kinase B isoform 2

Status: REVIEWED

Source sequence(s)

AL645902
NM_001425431.1 → NP_001412360.1 aurora kinase B isoform 3

Status: REVIEWED

Source sequence(s)

AL645902
NM_001425432.1 → NP_001412361.1 aurora kinase B isoform 4

Status: REVIEWED

Source sequence(s)

AL645902
NM_001425433.1 → NP_001412362.1 aurora kinase B isoform 4

Status: REVIEWED

Source sequence(s)

AL645902
NM_011496.3 → NP_035626.1 aurora kinase B isoform 1

See identical proteins and their annotated locations for NP_035626.1

Status: REVIEWED

Source sequence(s)

AL645902

Consensus CDS

CCDS24877.1

UniProtKB/Swiss-Prot

O70126, Q61882, Q8C6C1

Related

ENSMUSP00000021277.6, ENSMUST00000021277.6

Conserved Domains (2) summary

smart00220
Location:82 → 332

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:77 → 344

PKc_like; Protein Kinases, catalytic domain