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MYLK3 myosin light chain kinase 3 [ Homo sapiens (human) ]

Gene ID: 91807, updated on 23-Nov-2021

Summary

Official Symbol
MYLK3provided by HGNC
Official Full Name
myosin light chain kinase 3provided by HGNC
Primary source
HGNC:HGNC:29826
See related
Ensembl:ENSG00000140795 MIM:612147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLCK; MLCK2; caMLCK
Summary
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Expression
Biased expression in heart (RPKM 28.3), testis (RPKM 4.8) and 2 other tissues See more
Orthologs
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Genomic context

See MYLK3 in Genome Data Viewer
Location:
16q11.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (46702282..46763246, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46736194..46797158, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene VPS35 retromer complex component Neighboring gene origin recognition complex subunit 6 Neighboring gene NFE2 like bZIP transcription factor 3 pseudogene Neighboring gene chromosome 16 open reading frame 87

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126319, MGC126320

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables myosin light chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables myosin light chain kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cardiac myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of sarcomere organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of vascular permeability involved in acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sarcomere organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sarcomerogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
myosin light chain kinase 3
Names
MLC kinase
cardiac-MLCK
cardiac-MyBP-C associated Ca/CaM kinase
putative myosin light chain kinase 3
NP_001295230.1
NP_872299.2
XP_006721397.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308301.1NP_001295230.1  myosin light chain kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001295230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' most exon which results in a different 5' UTR and use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007225, AK299443
    Consensus CDS
    CCDS76861.1
    UniProtKB/Swiss-Prot
    Q32MK0
    Related
    ENSP00000439297.1, ENST00000536476.5
    Conserved Domains (2) summary
    smart00220
    Location:172429
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:169429
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  2. NM_182493.3NP_872299.2  myosin light chain kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_872299.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC007225, AJ247087, AL691746, CR739116, DA561361
    Consensus CDS
    CCDS10723.2
    UniProtKB/Swiss-Prot
    Q32MK0
    Related
    ENSP00000378288.4, ENST00000394809.9
    Conserved Domains (2) summary
    smart00220
    Location:513770
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:510770
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    46702282..46763246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721334.4XP_006721397.1  myosin light chain kinase 3 isoform X1

    See identical proteins and their annotated locations for XP_006721397.1

    UniProtKB/Swiss-Prot
    Q32MK0
    Conserved Domains (2) summary
    smart00220
    Location:172429
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:169429
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
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