Format

Send to:

Choose Destination

NEK9 NIMA related kinase 9 [ Homo sapiens (human) ]

Gene ID: 91754, updated on 21-Dec-2019

Summary

Official Symbol
NEK9provided by HGNC
Official Full Name
NIMA related kinase 9provided by HGNC
Primary source
HGNC:HGNC:18591
See related
Ensembl:ENSG00000119638 MIM:609798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NC; APUG; NERCC; LCCS10; NERCC1
Summary
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in ovary (RPKM 24.4), testis (RPKM 21.8) and 25 other tissues See more
Orthologs

Genomic context

See NEK9 in Genome Data Viewer
Location:
14q24.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (75079353..75127637, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75548818..75593778, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 689, pseudogene Neighboring gene mutL homolog 3 Neighboring gene acylphosphatase 1 Neighboring gene zinc finger C2HC-type containing 1C Neighboring gene HIF1AP pseudogene 1 Neighboring gene transmembrane p24 trafficking protein 10 Neighboring gene RNA, U4atac small nuclear 14, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of NIMA-related kinase 9 (NEK9) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16714, MGC138306, DKFZp434D0935

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek9
Names
NIMA (never in mitosis gene a)- related kinase 9
nercc1 kinase
nimA-related protein kinase 9
NP_001316166.1
NP_001316167.1
NP_149107.4
XP_005268266.1
XP_024305509.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051093.1 RefSeqGene

    Range
    5001..50702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329237.2NP_001316166.1  serine/threonine-protein kinase Nek9 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL049780
    UniProtKB/Swiss-Prot
    Q8TD19
    Conserved Domains (3) summary
    smart00220
    Location:52308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08221
    Location:51308
    STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
    pfam00415
    Location:444495
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  2. NM_001329238.2NP_001316167.1  serine/threonine-protein kinase Nek9 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL049780
    UniProtKB/Swiss-Prot
    Q8TD19
  3. NM_033116.6NP_149107.4  serine/threonine-protein kinase Nek9 isoform 2

    See identical proteins and their annotated locations for NP_149107.4

    Status: REVIEWED

    Source sequence(s)
    AL049780
    Consensus CDS
    CCDS9839.1
    UniProtKB/Swiss-Prot
    Q8TD19
    UniProtKB/TrEMBL
    Q6PKF2
    Related
    ENSP00000238616.5, ENST00000238616.10
    Conserved Domains (3) summary
    smart00220
    Location:52308
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08221
    Location:51308
    STKc_Nek9; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9
    pfam00415
    Location:500547
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    75079353..75127637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449741.1XP_024305509.1  serine/threonine-protein kinase Nek9 isoform X1

    Conserved Domains (2) summary
    cl21453
    Location:1190
    PKc_like; Protein Kinases, catalytic domain
    cl27697
    Location:227582
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  2. XM_005268209.3XP_005268266.1  serine/threonine-protein kinase Nek9 isoform X1

    Conserved Domains (2) summary
    cl21453
    Location:1190
    PKc_like; Protein Kinases, catalytic domain
    cl27697
    Location:227582
    RCC1; Regulator of chromosome condensation (RCC1) repeat
Support Center