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TAF1A TATA-box binding protein associated factor, RNA polymerase I subunit A [ Homo sapiens (human) ]

Gene ID: 9015, updated on 15-Apr-2019

Summary

Official Symbol
TAF1Aprovided by HGNC
Official Full Name
TATA-box binding protein associated factor, RNA polymerase I subunit Aprovided by HGNC
Primary source
HGNC:HGNC:11532
See related
Ensembl:ENSG00000143498 MIM:604903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SL1; RAFI48; TAFI48; MGC:17061
Summary
This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in testis (RPKM 2.3), lymph node (RPKM 1.9) and 24 other tissues See more
Orthologs

Genomic context

See TAF1A in Genome Data Viewer
Location:
1q41
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (222557902..222590096, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222730990..222763438, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372956 Neighboring gene RNA, U6 small nuclear 791, pseudogene Neighboring gene HHIP like 2 Neighboring gene uncharacterized LOC107985318 Neighboring gene TAF1A antisense RNA 1 Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene prefoldin subunit 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase I transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
TATA box-binding protein-associated factor RNA polymerase I subunit A
Names
RNA polymerase I-specific TBP-associated factor 48 kDa
SL1, 48kD subunit
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kD
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TATA box-binding protein-associated factor 1A
TATA-box binding protein associated factor, RNA polymerase I, A
TBP-associated factor 1A
transcription factor SL1
transcription initiation factor SL1/TIF-IB subunit A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201536.1NP_001188465.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1

    See identical proteins and their annotated locations for NP_001188465.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AK290970, AK299536, AL592148
    Consensus CDS
    CCDS1531.1
    UniProtKB/Swiss-Prot
    Q15573
    UniProtKB/TrEMBL
    A8K4K5, B4DS21
    Related
    ENSP00000339976.4, ENST00000350027.8
    Conserved Domains (1) summary
    pfam14929
    Location:63423
    TAF1_subA; TAF RNA Polymerase I subunit A
  2. NM_005681.4NP_005672.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1

    See identical proteins and their annotated locations for NP_005672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK299536, AL592148, BC013808, CN479053
    Consensus CDS
    CCDS1531.1
    UniProtKB/Swiss-Prot
    Q15573
    UniProtKB/TrEMBL
    B4DS21
    Related
    ENSP00000327072.6, ENST00000352967.9
    Conserved Domains (1) summary
    pfam14929
    Location:63423
    TAF1_subA; TAF RNA Polymerase I subunit A
  3. NM_139352.2NP_647603.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2

    See identical proteins and their annotated locations for NP_647603.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. These differences causes translation initiation at a downstream AUG and result in isoform (2) which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK001054, AK299536, AL592148
    Consensus CDS
    CCDS1532.1
    UniProtKB/Swiss-Prot
    Q15573
    UniProtKB/TrEMBL
    B4DS21
    Related
    ENSP00000355856.1, ENST00000366890.5
    Conserved Domains (1) summary
    pfam14929
    Location:2329
    TAF1_subA; TAF RNA Polymerase I subunit A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    222557902..222590096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002759.1XP_016858248.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X2

    UniProtKB/Swiss-Prot
    Q15573
    Conserved Domains (1) summary
    pfam14929
    Location:2329
    TAF1_subA; TAF RNA Polymerase I subunit A
  2. XM_017002758.1XP_016858247.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X1

    Conserved Domains (1) summary
    pfam14929
    Location:8405
    TAF1_subA; TAF RNA Polymerase I subunit A
  3. XM_006711612.1XP_006711675.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X1

    Conserved Domains (1) summary
    pfam14929
    Location:8405
    TAF1_subA; TAF RNA Polymerase I subunit A
  4. XM_006711613.3XP_006711676.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X2

    See identical proteins and their annotated locations for XP_006711676.1

    UniProtKB/Swiss-Prot
    Q15573
    Conserved Domains (1) summary
    pfam14929
    Location:2329
    TAF1_subA; TAF RNA Polymerase I subunit A
  5. XM_017002760.1XP_016858249.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X2

    UniProtKB/Swiss-Prot
    Q15573
    Conserved Domains (1) summary
    pfam14929
    Location:2329
    TAF1_subA; TAF RNA Polymerase I subunit A
  6. XM_005273343.4XP_005273400.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X3

    See identical proteins and their annotated locations for XP_005273400.1

    UniProtKB/TrEMBL
    B4DS21
    Conserved Domains (1) summary
    pfam14929
    Location:8303
    TAF1_subA; TAF RNA Polymerase I subunit A

RNA

  1. XR_001737526.2 RNA Sequence

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