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Taf1a TATA-box binding protein associated factor, RNA polymerase I, A [ Mus musculus (house mouse) ]

Gene ID: 21339, updated on 6-Jun-2024

Summary

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Official Symbol
Taf1aprovided by MGI
Official Full Name
TATA-box binding protein associated factor, RNA polymerase I, Aprovided by MGI
Primary source
MGI:MGI:109578
See related
Ensembl:ENSMUSG00000072258 AllianceGenome:MGI:109578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAFI48; mTAFI48
Summary
Predicted to enable DNA binding activity. Predicted to act upstream of or within transcription by RNA polymerase I. Predicted to be located in microtubule cytoskeleton and nucleoplasm. Predicted to be part of RNA polymerase I transcription regulator complex. Orthologous to human TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.3), bladder adult (RPKM 6.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Taf1a in Genome Data Viewer
Location:
1; 1 H5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (183170251..183195776)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (183388885..183410201)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene predicted gene, 34102 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene hedgehog interacting protein-like 2 Neighboring gene predicted gene, 33973 Neighboring gene STARR-seq mESC enhancer starr_03295 Neighboring gene predicted gene, 39724

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex. Murano K, et al. J Cell Sci, 2014 Aug 1. PMID 24928901
  2. Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1. Heix J, et al. Proc Natl Acad Sci U S A, 1997 Mar 4. PMID 9050847, Free PMC Article
  3. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. Yamamoto K, et al. Mol Cell Biol, 2004 Jul. PMID 15226435, Free PMC Article
  4. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Fanis P, et al. Mol Cell Proteomics, 2012 Nov. PMID 22872859, Free PMC Article
  5. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within transcription by RNA polymerase I TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase I transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 
part_of RNA polymerase transcription factor SL1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of RNA polymerase transcription factor SL1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TATA box-binding protein-associated factor RNA polymerase I subunit A
Names
RNA polymerase I-specific TBP-associated factor 48 kDa
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
TATA box-binding protein-associated factor 1A
TBP-associated factor 1A
transcription initiation factor SL1/TIF-IB subunit A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277957.2 → NP_001264886.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2

    See identical proteins and their annotated locations for NP_001264886.1

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108034, LXEJ02002843
    UniProtKB/TrEMBL
    B9EHT7, Q3V054
    Conserved Domains (1) summary
    pfam14929
    Location:64 → 411
    TAF1_subA; TAF RNA Polymerase I subunit A

  2. NM_001277958.2 → NP_001264887.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108034, LXEJ02002843
    UniProtKB/TrEMBL
    Q3V054
    Conserved Domains (1) summary
    pfam14929
    Location:9 → 451
    TAF1_subA; TAF RNA Polymerase I subunit A

  3. NM_001277959.2 → NP_001264888.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1

    See identical proteins and their annotated locations for NP_001264888.1

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108034, LXEJ02002843
    UniProtKB/Swiss-Prot
    P97357
    UniProtKB/TrEMBL
    Q3V054
    Related
    ENSMUSP00000142213.3, ENSMUST00000192076.3
    Conserved Domains (1) summary
    pfam14929
    Location:9 → 444
    TAF1_subA; TAF RNA Polymerase I subunit A

  4. NM_001420538.1 → NP_001407467.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108034, LXEJ02002843
    UniProtKB/TrEMBL
    B9EHT7, Q3V054

  5. NM_021466.4 → NP_067441.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform 1

    See identical proteins and their annotated locations for NP_067441.1

    Status: VALIDATED

    Source sequence(s)
    AEKQ02108034, LXEJ02002843
    UniProtKB/Swiss-Prot
    P97357
    UniProtKB/TrEMBL
    Q3V054
    Conserved Domains (1) summary
    pfam14929
    Location:9 → 444
    TAF1_subA; TAF RNA Polymerase I subunit A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    183170251..183195776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941413.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97357.1 GenPept UniProtKB/Swiss-Prot:P97357

Gene LinkOut

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