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SLC25A21 solute carrier family 25 member 21 [ Homo sapiens (human) ]

Gene ID: 89874, updated on 12-Oct-2019

Summary

Official Symbol
SLC25A21provided by HGNC
Official Full Name
solute carrier family 25 member 21provided by HGNC
Primary source
HGNC:HGNC:14411
See related
Ensembl:ENSG00000183032 MIM:607571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODC; ODC1
Summary
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
Expression
Biased expression in esophagus (RPKM 5.4), salivary gland (RPKM 2.6) and 13 other tissues See more
Orthologs

Genomic context

See SLC25A21 in Genome Data Viewer
Location:
14q13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (36677318..37172606, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (37147126..37641865, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 257 Neighboring gene uncharacterized LOC105370455 Neighboring gene PAX9 promoter region Neighboring gene paired box 9 Neighboring gene uncharacterized LOC107984668 Neighboring gene microRNA 4503 Neighboring gene SLC25A21 antisense RNA 1 Neighboring gene RNA, U6 small nuclear 273, pseudogene Neighboring gene VISTA enhancer hs593 Neighboring gene mirror-image polydactyly 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of solute carrier family 25, member 21 (SLC25A21) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, organism-specific biosystem (from REACTOME)
    Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism, organism-specific biosystemThe catabolic pathways of histidine, lysine, phenylalanine, tyrosine, proline and tryptophan are described in this section (Berg et al. 2002).
  • Lysine catabolism, organism-specific biosystem (from REACTOME)
    Lysine catabolism, organism-specific biosystemIn humans, most catabolism of L-lysine normally proceeds via a sequence of seven reactions which feeds into the pathway for fatty acid catabolism. In the first two reactions, catalyzed by a single en...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126570

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-ketoglutarate transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
alpha-ketoglutarate transport IEA
Inferred from Electronic Annotation
more info
 
lysine catabolic process TAS
Traceable Author Statement
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
mitochondrial 2-oxodicarboxylate carrier
Names
oxodicarboxylate carrier
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171170.2NP_001164641.1  mitochondrial 2-oxodicarboxylate carrier isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a split 3' exon, as compared to variant 1. The resulting isoform (2) lacks the last aa, as compared to isoform 1.
    Source sequence(s)
    AJ278148, AK289575, AL079303
    Consensus CDS
    CCDS55913.1
    UniProtKB/Swiss-Prot
    Q9BQT8
    Related
    ENSP00000451873.1, ENST00000555449.5
    Conserved Domains (2) summary
    PTZ00168
    Location:12283
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:15105
    Mito_carr; Mitochondrial carrier protein
  2. NM_030631.4NP_085134.1  mitochondrial 2-oxodicarboxylate carrier isoform 1

    See identical proteins and their annotated locations for NP_085134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes isoform 1.
    Source sequence(s)
    AJ278148, AL079303
    Consensus CDS
    CCDS9663.1
    UniProtKB/Swiss-Prot
    Q9BQT8
    Related
    ENSP00000329452.5, ENST00000331299.6
    Conserved Domains (1) summary
    pfam00153
    Location:15105
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    36677318..37172606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537287.3XP_011535589.1  mitochondrial 2-oxodicarboxylate carrier isoform X1

    Conserved Domains (2) summary
    PTZ00168
    Location:22287
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:209302
    Mito_carr; Mitochondrial carrier protein
  2. XM_011537288.3XP_011535590.1  mitochondrial 2-oxodicarboxylate carrier isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:175268
    Mito_carr; Mitochondrial carrier protein
  3. XM_011537289.3XP_011535591.1  mitochondrial 2-oxodicarboxylate carrier isoform X3

    Conserved Domains (1) summary
    pfam00153
    Location:173266
    Mito_carr; Mitochondrial carrier protein
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