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CFLAR CASP8 and FADD like apoptosis regulator [ Homo sapiens (human) ]

Gene ID: 8837, updated on 4-Nov-2018

Summary

Official Symbol
CFLARprovided by HGNC
Official Full Name
CASP8 and FADD like apoptosis regulatorprovided by HGNC
Primary source
HGNC:HGNC:1876
See related
Ensembl:ENSG00000003402 MIM:603599; Vega:OTTHUMG00000132819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CASH; FLIP; MRIT; CLARP; FLAME; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1
Summary
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in fat (RPKM 11.3), bone marrow (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See CFLAR in Genome Data Viewer
Location:
2q33.1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (201116104..201172688)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201980877..202037411)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373836 Neighboring gene ribosomal protein L17 pseudogene 10 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 10 Neighboring gene CFLAR antisense RNA 1 Neighboring gene RNA, U7 small nuclear 45 pseudogene Neighboring gene ribosomal protein L38 pseudogene Neighboring gene caspase 10 Neighboring gene MT-ND5 pseudogene 25 Neighboring gene MT-ND4L pseudogene 13 Neighboring gene MT-ND4 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of CASP8 and FADD-like apoptosis regulator (CFLAR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Trafficking of HIV-1 gp120 to lipid rafts is blocked by expression of cFLIP PubMed
env HIV-1 Env-pseudotyped virus-infected monocyte-derived macrophage cells downregulate expression of TRAIL decoy receptors DcR1 and DcR2, and cellular FLICE-inhibitory protein (c-FLIP) PubMed
env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
capsid gag cFLIP-induced upregulation of TRIM-5alpha expression inhibits HIV-1 CA expression PubMed
gag Trafficking of HIV-1 CA to lipid rafts is blocked by expression of cFLIP, which causes decreased levels of TSG101 and Alix at the plasma membrane PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • CASP8 activity is inhibited, organism-specific biosystem (from REACTOME)
    CASP8 activity is inhibited, organism-specific biosystemCell death triggered by extrinsic stimuli via death receptors or toll-like receptors (e.g., TLR3, TLR4) may result in either apoptosis or regulated necrosis (necroptosis) (Holler N et al. 2000; Kalai...
  • Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystem (from REACTOME)
    Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
    Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
  • Dimerization of procaspase-8, organism-specific biosystem (from REACTOME)
    Dimerization of procaspase-8, organism-specific biosystemProcaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become acc...
  • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    FAS (CD95) signaling pathway, organism-specific biosystem
    FAS (CD95) signaling pathway
  • Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystem (from WikiPathways)
    Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
  • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
    HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
    HIV-1 Nef: Negative effector of Fas and TNF-alpha
  • Ligand-dependent caspase activation, organism-specific biosystem (from REACTOME)
    Ligand-dependent caspase activation, organism-specific biosystemCaspase-8 is synthesized as zymogen (procaspase-8) and is formed from procaspase-8 as a cleavage product. However, the cleavage itself appears not to be sufficient for the formation of an active casp...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Nanomaterial induced apoptosis, organism-specific biosystem (from WikiPathways)
    Nanomaterial induced apoptosis, organism-specific biosystemApotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been fou...
  • Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystemPhotodynamic therapy may induce an acute stress response mediated by mitogen-activated protein kinase kinase kinase 5 (MAP3K5), its downstream MAPKs that target c-Jun N-terminal kinase (JNK, MAPK8) a...
  • Photodynamic therapy-induced NF-kB survival signaling, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced NF-kB survival signaling, organism-specific biosystemPhotodynamic therapy may induce a pro-inflammatory and angiogenic response mediated by NF-?B.
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
  • RIPK1-mediated regulated necrosis, organism-specific biosystem (from REACTOME)
    RIPK1-mediated regulated necrosis, organism-specific biosystemReceptor-interacting kinase protein 1 (RIPK1) and RIPK3-dependent necrosis is called necroptosis or programmed necrosis. The kinase activities of RIPK1 and RIPK3 are essential for the necroptotic cel...
  • Regulated Necrosis, organism-specific biosystem (from REACTOME)
    Regulated Necrosis, organism-specific biosystemNecrosis has traditionally been considered as a passive, unregulated cell death. However, accumulating evidence suggests that necrosis, like apoptosis, can be executed by genetically controlled and h...
  • Regulation by c-FLIP, organism-specific biosystem (from REACTOME)
    Regulation by c-FLIP, organism-specific biosystemc-FLIP proteins (CASP8 and FADD-like apoptosis regulators or c-FLICE inhibitory proteins) are death effector domain (DED)-containing proteins that are recruited to the death-inducing signaling comple...
  • Regulation of necroptotic cell death, organism-specific biosystem (from REACTOME)
    Regulation of necroptotic cell death, organism-specific biosystemA regulated balance between cell survival and cell death is essential for normal development and homeostasis of multicellular organisms. Defects in control of this balance may contribute to autoimmu...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TRAIL signaling, organism-specific biosystem (from REACTOME)
    TRAIL signaling, organism-specific biosystemTumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work throug...
  • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TRAIL signaling pathway, organism-specific biosystem
    TRAIL signaling pathway
  • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
    Validated targets of C-MYC transcriptional repression, organism-specific biosystem
    Validated targets of C-MYC transcriptional repression

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
death receptor binding IEA
Inferred from Electronic Annotation
more info
 
enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activator activity IEA
Inferred from Electronic Annotation
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to epidermal growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to nitric oxide IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
negative regulation of hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of necroptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of reactive oxygen species biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glomerular mesangial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of skeletal muscle satellite cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to bacterium IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle atrophy ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal muscle tissue regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
CD95 death-inducing signaling complex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
death-inducing signaling complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
ripoptosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CASP8 and FADD-like apoptosis regulator
Names
FADD-like antiapoptotic molecule 1
MACH-related inducer of toxicity
caspase homolog
caspase-eight-related protein
caspase-like apoptosis regulatory protein
caspase-related inducer of apoptosis
cellular FLICE-like inhibitory protein
inhibitor of FLICE
testis secretory sperm-binding protein Li 233m
usurpin beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029005.1 RefSeqGene

    Range
    4951..61535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127183.3NP_001120655.1  CASP8 and FADD-like apoptosis regulator isoform 1

    See identical proteins and their annotated locations for NP_001120655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS2337.1
    UniProtKB/Swiss-Prot
    O15519
    UniProtKB/TrEMBL
    A0A024R3Z7
    Related
    ENSP00000399420.2, OTTHUMP00000206480, ENST00000423241.6
    Conserved Domains (3) summary
    smart00115
    Location:244479
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  2. NM_001127184.3NP_001120656.1  CASP8 and FADD-like apoptosis regulator isoform 2

    See identical proteins and their annotated locations for NP_001120656.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate coding exon that results in a shorter protein isoform (2) with a distinct C-terminus. Variants 3, 12, and 13 all encode the same isoform (2).
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS46487.1
    UniProtKB/Swiss-Prot
    O15519
    Related
    ENSP00000339335.6, OTTHUMP00000206476, ENST00000341222.10
    Conserved Domains (2) summary
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  3. NM_001202515.1NP_001189444.1  CASP8 and FADD-like apoptosis regulator isoform 3

    See identical proteins and their annotated locations for NP_001189444.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC007283, AF041459, BM969271
    UniProtKB/Swiss-Prot
    O15519
    Conserved Domains (1) summary
    smart00115
    Location:1234
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  4. NM_001202516.2NP_001189445.1  CASP8 and FADD-like apoptosis regulator isoform 4

    See identical proteins and their annotated locations for NP_001189445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS56157.1
    UniProtKB/Swiss-Prot
    O15519
    UniProtKB/TrEMBL
    A0A024R3Y3
    Related
    ENSP00000345807.6, OTTHUMP00000206478, ENST00000341582.10
    Conserved Domains (3) summary
    smart00115
    Location:209444
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  5. NM_001202517.2NP_001189446.1  CASP8 and FADD-like apoptosis regulator isoform 5

    See identical proteins and their annotated locations for NP_001189446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 14, and 15 all encode the same isoform (5).
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS56158.1
    UniProtKB/Swiss-Prot
    O15519
    Related
    ENSP00000413270.1, OTTHUMP00000206475, ENST00000443227.5
    Conserved Domains (2) summary
    smart00115
    Location:148383
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08340
    Location:175
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  6. NM_001202518.1NP_001189447.1  CASP8 and FADD-like apoptosis regulator isoform 6

    See identical proteins and their annotated locations for NP_001189447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Variants 7 and 8 both encode isoform 6.
    Source sequence(s)
    AC007283, AK304585, BM969271, CD699251
    Consensus CDS
    CCDS59436.1
    UniProtKB/Swiss-Prot
    O15519
    UniProtKB/TrEMBL
    B4E361
    Related
    ENSP00000471805.1, OTTHUMP00000270978, ENST00000479953.6, OTTHUMT00000336706
    Conserved Domains (2) summary
    cd08340
    Location:175
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:148337
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  7. NM_001202519.2NP_001189448.1  CASP8 and FADD-like apoptosis regulator isoform 6

    See identical proteins and their annotated locations for NP_001189448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Variants 7 and 8 both encode isoform 6.
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS59436.1
    UniProtKB/Swiss-Prot
    O15519
    Conserved Domains (2) summary
    cd08340
    Location:175
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:148337
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  8. NM_001308042.2NP_001294971.1  CASP8 and FADD-like apoptosis regulator isoform 7

    See identical proteins and their annotated locations for NP_001294971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and contains an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and distinct 3' UTR. The resulting isoform (7) is shorter and has a distinct C-terminus compared to isoform 1. Variants 9 and 11 both encode the same isoform (7).
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS77505.1
    UniProtKB/Swiss-Prot
    O15519
    Related
    ENSP00000411535.1, OTTHUMP00000206482, ENST00000457277.5
    Conserved Domains (3) summary
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:244433
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  9. NM_001308043.1NP_001294972.1  CASP8 and FADD-like apoptosis regulator isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks multiple exons in the central and 3' coding regions, and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (8) is significantly shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB209600, AC007283, DC375144
    Consensus CDS
    CCDS77503.1
    UniProtKB/TrEMBL
    E9PAP3, Q59F61
    Related
    ENSP00000378580.2, OTTHUMP00000206477, ENST00000395148.6, OTTHUMT00000336699
    Conserved Domains (2) summary
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  10. NM_001351590.1NP_001338519.1  CASP8 and FADD-like apoptosis regulator isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 9, encodes isoform 7.
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS77505.1
    Conserved Domains (3) summary
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:244433
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  11. NM_001351591.1NP_001338520.1  CASP8 and FADD-like apoptosis regulator isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 3 and 13, encodes isoform 2.
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS46487.1
    Conserved Domains (2) summary
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  12. NM_001351592.1NP_001338521.1  CASP8 and FADD-like apoptosis regulator isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 3 and 12, encodes isoform 2.
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS46487.1
    Related
    ENSP00000406775.1, ENST00000440180.5
    Conserved Domains (2) summary
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  13. NM_001351593.1NP_001338522.1  CASP8 and FADD-like apoptosis regulator isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 6 and 15, encodes isoform 5.
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS56158.1
    Conserved Domains (2) summary
    smart00115
    Location:148383
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08340
    Location:175
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  14. NM_001351594.1NP_001338523.1  CASP8 and FADD-like apoptosis regulator isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 6 and 14, encodes isoform 5.
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS56158.1
    Conserved Domains (2) summary
    smart00115
    Location:148383
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08340
    Location:175
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  15. NM_003879.6NP_003870.4  CASP8 and FADD-like apoptosis regulator isoform 1

    See identical proteins and their annotated locations for NP_003870.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents use of an alternate first exon and encodes the longest protein isoform (1). Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC007283
    Consensus CDS
    CCDS2337.1
    UniProtKB/Swiss-Prot
    O15519
    UniProtKB/TrEMBL
    A0A024R3Z7
    Related
    ENSP00000312455.2, OTTHUMP00000163715, ENST00000309955.7
    Conserved Domains (3) summary
    smart00115
    Location:244479
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

RNA

  1. NR_147241.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  2. NR_147242.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  3. NR_147243.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  4. NR_147244.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  5. NR_147245.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  6. NR_147246.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  7. NR_147247.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  8. NR_147248.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  9. NR_147249.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  10. NR_147250.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  11. NR_147251.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  12. NR_147252.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
    Related
    ENST00000490965.1
  13. NR_147253.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283
  14. NR_147255.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007283

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    201116104..201172688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005189.2XP_016860678.1  CASP8 and FADD-like apoptosis regulator isoform X2

  2. XM_017005195.2XP_016860684.1  CASP8 and FADD-like apoptosis regulator isoform X4

    UniProtKB/Swiss-Prot
    O15519
    Conserved Domains (2) summary
    smart00115
    Location:148383
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08340
    Location:175
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  3. XM_017005193.2XP_016860682.1  CASP8 and FADD-like apoptosis regulator isoform X3

    UniProtKB/Swiss-Prot
    O15519
    Conserved Domains (3) summary
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    cl00042
    Location:244433
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  4. XM_017005191.2XP_016860680.1  CASP8 and FADD-like apoptosis regulator isoform X1

    UniProtKB/Swiss-Prot
    O15519
    UniProtKB/TrEMBL
    A0A024R3Z7
    Conserved Domains (3) summary
    smart00115
    Location:244479
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  5. XM_017005190.2XP_016860679.1  CASP8 and FADD-like apoptosis regulator isoform X1

    UniProtKB/Swiss-Prot
    O15519
    UniProtKB/TrEMBL
    A0A024R3Z7
    Conserved Domains (3) summary
    smart00115
    Location:244479
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:180
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:91171
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

RNA

  1. XR_002959355.1 RNA Sequence

  2. XR_001739013.2 RNA Sequence

  3. XR_001739017.2 RNA Sequence

  4. XR_002959354.1 RNA Sequence

  5. XR_001739016.2 RNA Sequence

  6. XR_001739018.1 RNA Sequence

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