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Cflar CASP8 and FADD-like apoptosis regulator [ Mus musculus (house mouse) ]

Gene ID: 12633, updated on 8-Dec-2022

Summary

Official Symbol
Cflarprovided by MGI
Official Full Name
CASP8 and FADD-like apoptosis regulatorprovided by MGI
Primary source
MGI:MGI:1336166
See related
Ensembl:ENSMUSG00000026031 AllianceGenome:MGI:1336166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cash; Flip; MRIT; CLARP; FLAME; Casper; Gm9845; c-Flip; FLAME-1; I-FLICE; 2310024N18Rik; A430105C05Rik
Summary
Enables peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; positive regulation of NF-kappaB transcription factor activity; and skeletal muscle atrophy. Acts upstream of or within negative regulation of programmed cell death and response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 9.2), kidney adult (RPKM 7.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cflar in Genome Data Viewer
Location:
1 C1.3; 1 29.16 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58750353..58798043)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58711311..58758884)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene caspase 8 pseudogene Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene predicted gene, 39646 Neighboring gene caspase 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC103395

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables death receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in keratinocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of skeletal muscle satellite cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to testosterone ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle atrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CD95 death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of death-inducing signaling complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of ripoptosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CASP8 and FADD-like apoptosis regulator
Names
FADD-like antiapoptotic molecule 1
MACH-related inducer of toxicity
caspase homolog
caspase-eight-related protein
caspase-like apoptosis regulatory protein
cellular FLICE-like inhibitory protein
inhibitor of FLICE
usurpin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289704.3NP_001276633.1  CASP8 and FADD-like apoptosis regulator isoform 1

    See identical proteins and their annotated locations for NP_001276633.1

    Status: VALIDATED

    Source sequence(s)
    AC112968
    Consensus CDS
    CCDS14978.1
    UniProtKB/Swiss-Prot
    O35732, O35733
    UniProtKB/TrEMBL
    Q812G4
    Related
    ENSMUSP00000109952.2, ENSMUST00000114313.8
    Conserved Domains (3) summary
    smart00115
    Location:246480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  2. NM_001293804.2NP_001280733.1  CASP8 and FADD-like apoptosis regulator isoform 4

    See identical proteins and their annotated locations for NP_001280733.1

    Status: VALIDATED

    Source sequence(s)
    AC112968, AK152515
    Conserved Domains (1) summary
    smart00115
    Location:60294
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  3. NM_001293805.2NP_001280734.1  CASP8 and FADD-like apoptosis regulator isoform 4

    See identical proteins and their annotated locations for NP_001280734.1

    Status: VALIDATED

    Source sequence(s)
    AC112968, AK161120
    Conserved Domains (1) summary
    smart00115
    Location:60294
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  4. NM_001355056.1NP_001341985.1  CASP8 and FADD-like apoptosis regulator isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC112968
    Conserved Domains (1) summary
    smart00115
    Location:60294
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
  5. NM_009805.4NP_033935.2  CASP8 and FADD-like apoptosis regulator isoform 2

    See identical proteins and their annotated locations for NP_033935.2

    Status: VALIDATED

    Source sequence(s)
    BB856464, BC085105
    Consensus CDS
    CCDS35582.1
    UniProtKB/TrEMBL
    Q5U4G3
    Related
    ENSMUSP00000109948.2, ENSMUST00000114309.8
    Conserved Domains (2) summary
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  6. NM_207653.6NP_997536.1  CASP8 and FADD-like apoptosis regulator isoform 1

    See identical proteins and their annotated locations for NP_997536.1

    Status: VALIDATED

    Source sequence(s)
    AC112968
    Consensus CDS
    CCDS14978.1
    UniProtKB/Swiss-Prot
    O35732, O35733
    UniProtKB/TrEMBL
    Q812G4
    Related
    ENSMUSP00000065107.8, ENSMUST00000069333.8
    Conserved Domains (3) summary
    smart00115
    Location:246480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

RNA

  1. NR_149255.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112968
  2. NR_149256.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112968
    Related
    ENSMUST00000156870.2
  3. NR_149257.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112968, BX524743
    Related
    ENSMUST00000124567.2
  4. NR_149258.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112968
    Related
    ENSMUST00000149874.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58750353..58798043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238421.4XP_011236723.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_011236723.1

    UniProtKB/Swiss-Prot
    O35732, O35733
    UniProtKB/TrEMBL
    Q812G4
    Related
    ENSMUSP00000095329.3, ENSMUST00000097722.9
    Conserved Domains (3) summary
    smart00115
    Location:246480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  2. XM_011238420.4XP_011236722.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_011236722.1

    UniProtKB/Swiss-Prot
    O35732, O35733
    UniProtKB/TrEMBL
    Q812G4
    Conserved Domains (3) summary
    smart00115
    Location:246480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  3. XM_030244988.2XP_030100848.1  CASP8 and FADD-like apoptosis regulator isoform X1

    UniProtKB/Swiss-Prot
    O35733
    UniProtKB/TrEMBL
    Q812G4
    Conserved Domains (3) summary
    smart00115
    Location:246480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  4. XM_011238422.1XP_011236724.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_011236724.1

    UniProtKB/Swiss-Prot
    O35732, O35733
    UniProtKB/TrEMBL
    Q812G4
    Conserved Domains (3) summary
    smart00115
    Location:246480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  5. XM_011238423.4XP_011236725.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_011236725.1

    UniProtKB/Swiss-Prot
    O35732, O35733
    UniProtKB/TrEMBL
    Q812G4
    Conserved Domains (3) summary
    smart00115
    Location:246480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  6. XM_006495635.5XP_006495698.1  CASP8 and FADD-like apoptosis regulator isoform X1

    See identical proteins and their annotated locations for XP_006495698.1

    UniProtKB/Swiss-Prot
    O35732, O35733
    UniProtKB/TrEMBL
    Q812G4
    Conserved Domains (3) summary
    smart00115
    Location:246480
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08337
    Location:685
    DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
    cd08340
    Location:96176
    DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
  7. XM_036156889.1XP_036012782.1  CASP8 and FADD-like apoptosis regulator isoform X2

    Conserved Domains (1) summary
    smart00115
    Location:60294
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues