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NRP2 neuropilin 2 [ Homo sapiens (human) ]

Gene ID: 8828, updated on 17-Jun-2019

Summary

Official Symbol
NRP2provided by HGNC
Official Full Name
neuropilin 2provided by HGNC
Primary source
HGNC:HGNC:8005
See related
Ensembl:ENSG00000118257 MIM:602070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP2; NPN2; PRO2714; VEGF165R2
Summary
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 10.6), ovary (RPKM 9.8) and 20 other tissues See more
Orthologs

Genomic context

See NRP2 in Genome Data Viewer
Location:
2q33.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (205682500..205798131)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (206547184..206662857)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373845 Neighboring gene par-3 family cell polarity regulator beta Neighboring gene Sharpr-MPRA regulatory region 14521 Neighboring gene uncharacterized LOC105373847 Neighboring gene RN7SK pseudogene 178

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of neuropilin 2 (NRP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of neuropilin 2 (NRP2) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • Neurophilin interactions with VEGF and VEGFR, organism-specific biosystem (from REACTOME)
    Neurophilin interactions with VEGF and VEGFR, organism-specific biosystemThe plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF...
  • NrCAM interactions, organism-specific biosystem (from REACTOME)
    NrCAM interactions, organism-specific biosystemThe NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
  • VEGFR1 specific signals, organism-specific biosystem (from Pathway Interaction Database)
    VEGFR1 specific signals, organism-specific biosystem
    VEGFR1 specific signals

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126574

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine binding NAS
Non-traceable Author Statement
more info
PubMed 
growth factor binding TAS
Traceable Author Statement
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
semaphorin receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
axon extension involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
axon guidance NAS
Non-traceable Author Statement
more info
PubMed 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
dorsal root ganglion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
facial nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
facioacoustic ganglion development IEA
Inferred from Electronic Annotation
more info
 
gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
Inferred from Electronic Annotation
more info
 
negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 
nerve development ISS
Inferred from Sequence or Structural Similarity
more info
 
neural crest cell migration involved in autonomic nervous system development IEA
Inferred from Electronic Annotation
more info
 
outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
semaphorin-plexin signaling pathway involved in neuron projection guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
sympathetic ganglion development ISS
Inferred from Sequence or Structural Similarity
more info
 
sympathetic neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
 
sympathetic neuron projection guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
trigeminal ganglion development IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
ventral trunk neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
vestibulocochlear nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
semaphorin receptor complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
neuropilin-2
Names
neuropilin-2a(17)
neuropilin-2a(22)
neuropilin-2b(0)
receptor for VEGF165 and semaphorins class3
vascular endothelial cell growth factor 165 receptor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029567.1 RefSeqGene

    Range
    5001..120634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003872.3NP_003863.2  neuropilin-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_003863.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as NRP2a(17), lacks an alternate in-frame segment, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC007362, AC007561, KF459587
    Consensus CDS
    CCDS46496.1
    UniProtKB/Swiss-Prot
    O60462
    UniProtKB/TrEMBL
    Q7LBX6, Q7Z3T9
    Related
    ENSP00000350432.5, ENST00000357785.9
    Conserved Domains (4) summary
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam11980
    Location:845926
    DUF3481; C-terminal domain of neuropilin glycoprotein
  2. NM_018534.4NP_061004.3  neuropilin-2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_061004.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as NRP2b(5), lacks the last two 3' exons and includes an alternate 3' exon, compared to variant 1. This results in a shorter isoform (4) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC007362, KF459587
    Consensus CDS
    CCDS2365.1
    UniProtKB/Swiss-Prot
    O60462
    UniProtKB/TrEMBL
    Q7Z3T9
    Related
    ENSP00000272849.3, ENST00000272849.7
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:822901
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. NM_201264.1NP_957716.1  neuropilin-2 isoform 6 precursor

    See identical proteins and their annotated locations for NP_957716.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as S9NRP2b, lacks several 3' exons and uses an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. This results in a shorter, potentially soluble isoform (6) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF280546, AL833606, BX537423
    Consensus CDS
    CCDS46499.1
    UniProtKB/Swiss-Prot
    O60462
    UniProtKB/TrEMBL
    Q7Z3T9
    Related
    ENSP00000387519.1, ENST00000417189.5
    Conserved Domains (3) summary
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. NM_201266.2NP_957718.1  neuropilin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_957718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as NRP2a(22), represents the longest transcript, and encodes the longest isoform (1).
    Source sequence(s)
    AC007362, AC007561, KF459587
    Consensus CDS
    CCDS2364.1
    UniProtKB/Swiss-Prot
    O60462
    UniProtKB/TrEMBL
    Q7Z3T9, X5D2Q8
    Related
    ENSP00000353582.3, ENST00000360409.7
    Conserved Domains (4) summary
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam11980
    Location:850931
    DUF3481; C-terminal domain of neuropilin glycoprotein
  5. NM_201267.2NP_957719.1  neuropilin-2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_957719.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as NRP2b(0), includes an alternate 3' sequence, compared to variant 1. This results in a shorter isoform (5) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC007362, KF459587
    Consensus CDS
    CCDS46498.1
    UniProtKB/Swiss-Prot
    O60462
    UniProtKB/TrEMBL
    A0A024R412, Q7Z3T9
    Related
    ENSP00000349632.4, ENST00000357118.8
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:817896
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  6. NM_201279.2NP_958436.1  neuropilin-2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_958436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as NRP2a(0), lacks an in-frame segment and a following in-frame exon in the coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AC007362, AC007561, KF459587
    Consensus CDS
    CCDS46497.1
    UniProtKB/Swiss-Prot
    O60462
    UniProtKB/TrEMBL
    A0A024R3W6, Q7Z3T9
    Related
    ENSP00000407626.2, ENST00000412873.2
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:832906
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    205682500..205798131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005187.2XP_016860676.1  neuropilin-2 isoform X1

  2. XM_017005188.2XP_016860677.1  neuropilin-2 isoform X2

RNA

  1. XR_923055.3 RNA Sequence

  2. XR_923057.3 RNA Sequence

  3. XR_923056.3 RNA Sequence

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