NRP2 neuropilin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NRP2provided by HGNC
Official Full Name: neuropilin 2provided by HGNC
Primary source: HGNC:HGNC:8005
See related: Ensembl:ENSG00000118257 MIM:602070
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NP2; NPN2; PRO2714; VEGF165R2
Summary: This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression: Broad expression in placenta (RPKM 10.6), ovary (RPKM 9.8) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q33.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	2	NC_000002.12 (205682501..205798131)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (206547225..206662855)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma.
Title: Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma.
Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer.
Title: Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer.
MiR-146a Regulates Migration and Invasion by Targeting NRP2 in Circulating-Tumor Cell Mimicking Suspension Cells.
Title: MiR-146a Regulates Migration and Invasion by Targeting NRP2 in Circulating-Tumor Cell Mimicking Suspension Cells.
VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk.
Title: VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk.
Segregation Analysis of Rare NRP1 and NRP2 Variants in Families with Lymphedema.
Title: Segregation Analysis of Rare <i>NRP1</i> and <i>NRP2</i> Variants in Families with Lymphedema.
The Roles of Neuropilin 2/VEGF-C Axis in a Series of Recurrent Lymphangioma.
Title: The Roles of Neuropilin 2/VEGF-C Axis in a Series of Recurrent Lymphangioma.
Clinical significance of neuropilin-2 expression in laryngeal squamous cell carcinoma.
Title: Clinical significance of neuropilin-2 expression in laryngeal squamous cell carcinoma.
Influence of Human Cytomegalovirus Glycoprotein O Polymorphism on the Inhibitory Effect of Soluble Forms of Trimer- and Pentamer-Specific Entry Receptors.
Title: Influence of Human Cytomegalovirus Glycoprotein O Polymorphism on the Inhibitory Effect of Soluble Forms of Trimer- and Pentamer-Specific Entry Receptors.
Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects.
Title: Silencing of Neuropilins and GIPC1 in pancreatic ductal adenocarcinoma exerts multiple cellular and molecular antitumor effects.
Presence of the Transmembrane Protein Neuropilin in Cytokine-induced Killer Cells.
Title: Presence of the Transmembrane Protein Neuropilin in Cytokine-induced Killer Cells.

Submit: New GeneRIF Correction See all GeneRIFs (97)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of neuropilin 2 (NRP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of neuropilin 2 (NRP2) in human B cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-80012 (e-PCR)
- UniSTS:102144

SGC31090 (e-PCR)
- UniSTS:44054

STS-AA009628 (e-PCR)
- UniSTS:2328

NRP2_1404 (e-PCR)
- UniSTS:277541

NRP2_v462 (e-PCR)
- UniSTS:277541

D8S2279 (e-PCR)
- UniSTS:473907

D2S2128 (e-PCR)
- UniSTS:154175

RH99006 (e-PCR)
- UniSTS:92750

D2S1846 (e-PCR)
- UniSTS:28759

SHGC-146056 (e-PCR)
- UniSTS:174968

RH36188 (e-PCR)
- UniSTS:57471

RH68921 (e-PCR)
- UniSTS:52363

D16S325 (e-PCR)
- UniSTS:147089

SHGC-105157 (e-PCR)
- UniSTS:169169

Homology

Homologs of the NRP2 gene: The NRP2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 392 organisms have orthologs with human gene NRP2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine binding	NAS Non-traceable Author Statement more info	PubMed
enables growth factor binding	TAS Traceable Author Statement more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info
enables vascular endothelial growth factor-activated receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in axon extension involved in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	NAS Non-traceable Author Statement more info	PubMed
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in dorsal root ganglion morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in facial nerve structural organization	IEA Inferred from Electronic Annotation more info
involved_in facioacoustic ganglion development	IEA Inferred from Electronic Annotation more info
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in nerve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest cell migration involved in autonomic nervous system development	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in sympathetic ganglion development	ISS Inferred from Sequence or Structural Similarity more info
involved_in sympathetic neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in sympathetic neuron projection guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in trigeminal ganglion development	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ventral trunk neural crest cell migration	IEA Inferred from Electronic Annotation more info
involved_in vestibulocochlear nerve structural organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in integral component of membrane	NAS Non-traceable Author Statement more info	PubMed
located_in integral component of postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of semaphorin receptor complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: neuropilin-2

Names: neuropilin-2a(17); neuropilin-2a(22); neuropilin-2b(0); receptor for VEGF165 and semaphorins class3; vascular endothelial cell growth factor 165 receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029567.2 RefSeqGene

Range

5002..120632

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003872.3 → NP_003863.2 neuropilin-2 isoform 2 precursor

See identical proteins and their annotated locations for NP_003863.2

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as NRP2a(17), lacks an alternate in-frame segment, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AC007362, AC007561, KF459587

Consensus CDS

CCDS46496.1

UniProtKB/Swiss-Prot

O60462

UniProtKB/TrEMBL

Q7LBX6, Q7Z3T9

Related

ENSP00000350432.5, ENST00000357785.10

Conserved Domains (4) summary

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam11980
Location:845 → 926

DUF3481; C-terminal domain of neuropilin glycoprotein
NM_018534.4 → NP_061004.3 neuropilin-2 isoform 4 precursor

See identical proteins and their annotated locations for NP_061004.3

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as NRP2b(5), lacks the last two 3' exons and includes an alternate 3' exon, compared to variant 1. This results in a shorter isoform (4) with a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC007362, KF459587

Consensus CDS

CCDS2365.1

UniProtKB/Swiss-Prot

O60462

UniProtKB/TrEMBL

Q7Z3T9

Related

ENSP00000272849.3, ENST00000272849.7

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:822 → 901

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_201264.2 → NP_957716.1 neuropilin-2 isoform 6 precursor

See identical proteins and their annotated locations for NP_957716.1

Status: REVIEWED

Description

Transcript Variant: This variant (6), also known as S9NRP2b, lacks several 3' exons and uses an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. This results in a shorter, potentially soluble isoform (6) with a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC007362, KF459587

Consensus CDS

CCDS46499.1

UniProtKB/Swiss-Prot

O60462

UniProtKB/TrEMBL

Q7Z3T9

Related

ENSP00000387519.1, ENST00000417189.5

Conserved Domains (3) summary

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_201266.2 → NP_957718.1 neuropilin-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_957718.1

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as NRP2a(22), represents the longest transcript, and encodes the longest isoform (1).

Source sequence(s)

AC007362, AC007561, KF459587

Consensus CDS

CCDS2364.1

UniProtKB/Swiss-Prot

O60462

UniProtKB/TrEMBL

Q7Z3T9, X5D2Q8

Related

ENSP00000353582.3, ENST00000360409.7

Conserved Domains (4) summary

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam11980
Location:850 → 931

DUF3481; C-terminal domain of neuropilin glycoprotein
NM_201267.2 → NP_957719.1 neuropilin-2 isoform 5 precursor

See identical proteins and their annotated locations for NP_957719.1

Status: REVIEWED

Description

Transcript Variant: This variant (5), also known as NRP2b(0), includes an alternate 3' sequence, compared to variant 1. This results in a shorter isoform (5) with a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC007362, KF459587

Consensus CDS

CCDS46498.1

UniProtKB/Swiss-Prot

O60462

UniProtKB/TrEMBL

A0A024R412, Q7Z3T9

Related

ENSP00000349632.4, ENST00000357118.8

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:817 → 896

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_201279.2 → NP_958436.1 neuropilin-2 isoform 3 precursor

See identical proteins and their annotated locations for NP_958436.1

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as NRP2a(0), lacks an in-frame segment and a following in-frame exon in the coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.

Source sequence(s)

AC007362, AC007561, KF459587

Consensus CDS

CCDS46497.1

UniProtKB/Swiss-Prot

O60462

UniProtKB/TrEMBL

A0A024R3W6, Q7Z3T9

Related

ENSP00000407626.2, ENST00000412873.2

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:832 → 906

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.