Nrp2 neuropilin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrp2provided by MGI
Official Full Name: neuropilin 2provided by MGI
Primary source: MGI:MGI:1100492
See related: Ensembl:ENSMUSG00000025969 AllianceGenome:MGI:1100492
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Np2; Np-2; Npn2; Npn-2; 1110048P06Rik
Summary: Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and trunk neural crest cell migration. Located in axon. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in bladder adult (RPKM 32.3), limb E14.5 (RPKM 16.1) and 20 other tissues See more
Orthologs: all
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Genomic context

Location:: 1 C2; 1 31.35 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (62742476..62857851)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (62703317..62818692)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A proteomics approach to isolating neuropilin-dependent alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells.
Title: A proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells.
Neuropilin 2 Is a Novel Regulator of Distal Colon Contractility.
Title: Neuropilin 2 Is a Novel Regulator of Distal Colon Contractility.
Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice.
Title: Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice.
Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis.
Title: Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis.
Neuropilin-2 Inhibits Drug Resistance and Progression of Melanoma Involving the MiR-331-3p Regulated Cascade.
Title: Neuropilin-2 Inhibits Drug Resistance and Progression of Melanoma Involving the MiR-331-3p Regulated Cascade.
IKKbeta increases neuropilin-2 and promotes the inhibitory function of CD9<sup>+</sup> Bregs to control allergic diseases.
Title: IKKβ increases neuropilin-2 and promotes the inhibitory function of CD9(+) Bregs to control allergic diseases.
Alveolar macrophage-derived NRP2 curtails lung injury while boosting host defense in bacterial pneumonia.
Title: Alveolar macrophage-derived NRP2 curtails lung injury while boosting host defense in bacterial pneumonia.
Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer.
Title: Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer.
Neuropilin-2 regulates airway inflammation in a neutrophilic asthma model.
Title: Neuropilin-2 regulates airway inflammation in a neutrophilic asthma model.
Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2.
Title: Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Gene trapped (2) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nrp2 (e-PCR), detects polymorphism
- UniSTS:498435

PMC122579P1 (e-PCR)
- UniSTS:270399

Nrp2 (e-PCR), detects polymorphism
- UniSTS:531350

NoName (e-PCR)
- UniSTS:224197

BF397549 (e-PCR)
- UniSTS:246223

UniSTS:498396 (e-PCR)
- UniSTS:498396

Nrp2 (e-PCR), detects polymorphism
- UniSTS:498396

D1Mit379 (e-PCR), detects polymorphism
- UniSTS:128740

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in dorsal root ganglion morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dorsal root ganglion morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in facial nerve structural organization	IEA Inferred from Electronic Annotation more info
involved_in facial nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in facioacoustic ganglion development	IEA Inferred from Electronic Annotation more info
involved_in facioacoustic ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IEA Inferred from Electronic Annotation more info
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell migration involved in autonomic nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell migration involved in autonomic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic ganglion development	IEA Inferred from Electronic Annotation more info
involved_in sympathetic ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in sympathetic neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sympathetic neuron projection guidance	IEA Inferred from Electronic Annotation more info
involved_in sympathetic neuron projection guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trigeminal ganglion development	IEA Inferred from Electronic Annotation more info
involved_in trigeminal ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ventral trunk neural crest cell migration	IEA Inferred from Electronic Annotation more info
involved_in ventral trunk neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vestibulocochlear nerve structural organization	IEA Inferred from Electronic Annotation more info
involved_in vestibulocochlear nerve structural organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuropilin-2

Names: vascular endothelial cell growth factor 165 receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077403.1 → NP_001070871.1 neuropilin-2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AK149643, AK153553, AL671560, BY320114

Consensus CDS

CCDS35589.1

UniProtKB/Swiss-Prot

B1AT44, O35373, O35374, O35375, O35376, O35377, O35378

Related

ENSMUSP00000109794.3, ENSMUST00000114157.3

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:849 → 928

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001077404.1 → NP_001070872.1 neuropilin-2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AK149643, AL671560, BC098200, BY320114

Consensus CDS

CCDS35590.1

UniProtKB/TrEMBL

Q8QZY7

Related

ENSMUSP00000069379.7, ENSMUST00000063594.13

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:844 → 923

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001077405.1 → NP_001070873.1 neuropilin-2 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AK149643, AK153553, AL671560, BY320114

Consensus CDS

CCDS35591.1

UniProtKB/TrEMBL

Q3U5I8

Related

ENSMUSP00000099886.3, ENSMUST00000102822.9

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:827 → 906

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001077406.1 → NP_001070874.1 neuropilin-2 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AK149643, AK153553, AL671560, BY320114

Consensus CDS

CCDS35592.1

UniProtKB/TrEMBL

Q3U5I8

Related

ENSMUSP00000027112.7, ENSMUST00000027112.13

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:822 → 901

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_001077407.1 → NP_001070875.1 neuropilin-2 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AK149643, AK153553, BY320114

Consensus CDS

CCDS35593.1

UniProtKB/TrEMBL

Q3U5I8

Related

ENSMUSP00000109792.2, ENSMUST00000114155.8

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:817 → 896

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
NM_010939.2 → NP_035069.2 neuropilin-2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AK149643, AK153553, AL671560, BY320114

Consensus CDS

CCDS14995.1

UniProtKB/TrEMBL

Q3U5I8

Related

ENSMUSP00000074642.6, ENSMUST00000075144.12

Conserved Domains (6) summary

cd06263
Location:646 → 793

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

pfam11980
Location:832 → 911

DUF3481; Domain of unknown function (DUF3481)

smart00137
Location:641 → 794

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00231
Location:277 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00041
Location:28 → 141

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:280 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.