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Nrp2 neuropilin 2 [ Mus musculus (house mouse) ]

Gene ID: 18187, updated on 28-Dec-2022

Summary

Official Symbol
Nrp2provided by MGI
Official Full Name
neuropilin 2provided by MGI
Primary source
MGI:MGI:1100492
See related
Ensembl:ENSMUSG00000025969 AllianceGenome:MGI:1100492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Np2; Np-2; Npn2; Npn-2; 1110048P06Rik
Summary
Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and neural crest cell migration. Located in axon. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and limb. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 32.3), limb E14.5 (RPKM 16.1) and 20 other tissues See more
Orthologs
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Genomic context

See Nrp2 in Genome Data Viewer
Location:
1; 1 C2
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (62742476..62857851)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (62703317..62818692)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene par-3 family cell polarity regulator beta Neighboring gene predicted gene, 34881 Neighboring gene 40S ribosomal protein S2-like Neighboring gene RIKEN cDNA 4930487H11 gene Neighboring gene predicted gene 29083 Neighboring gene predicted gene, 35120 Neighboring gene predicted gene, 39652 Neighboring gene predicted gene 4208

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables semaphorin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dorsal root ganglion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in facial nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in facioacoustic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell migration involved in autonomic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in neuron projection guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic neuron projection guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in trigeminal ganglion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trunk neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in ventral trunk neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vestibulocochlear nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuropilin-2
Names
vascular endothelial cell growth factor 165 receptor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077403.1NP_001070871.1  neuropilin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001070871.1

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, AL671560, BY320114
    Consensus CDS
    CCDS35589.1
    UniProtKB/Swiss-Prot
    O35375, O35378
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000109794.3, ENSMUST00000114157.3
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:849928
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. NM_001077404.1NP_001070872.1  neuropilin-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070872.1

    Status: VALIDATED

    Source sequence(s)
    AK149643, AL671560, BC098200, BY320114
    Consensus CDS
    CCDS35590.1
    UniProtKB/TrEMBL
    Q8QZY7
    Related
    ENSMUSP00000069379.7, ENSMUST00000063594.13
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:844923
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. NM_001077405.1NP_001070873.1  neuropilin-2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, AL671560, BY320114
    Consensus CDS
    CCDS35591.1
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000099886.3, ENSMUST00000102822.9
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:827906
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. NM_001077406.1NP_001070874.1  neuropilin-2 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001070874.1

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, AL671560, BY320114
    Consensus CDS
    CCDS35592.1
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000027112.7, ENSMUST00000027112.13
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:822901
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  5. NM_001077407.1NP_001070875.1  neuropilin-2 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001070875.1

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, BY320114
    Consensus CDS
    CCDS35593.1
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000109792.2, ENSMUST00000114155.8
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:817896
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  6. NM_010939.2NP_035069.2  neuropilin-2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_035069.2

    Status: VALIDATED

    Source sequence(s)
    AK149643, AK153553, AL671560, BY320114
    Consensus CDS
    CCDS14995.1
    UniProtKB/TrEMBL
    Q3U5I8
    Related
    ENSMUSP00000074642.6, ENSMUST00000075144.12
    Conserved Domains (6) summary
    cd06263
    Location:646793
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam11980
    Location:832911
    DUF3481; Domain of unknown function (DUF3481)
    smart00137
    Location:641794
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00231
    Location:277427
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00041
    Location:28141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00057
    Location:280426
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    62742476..62857851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)