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JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough [ Homo sapiens (human) ]

Gene ID: 8681, updated on 1-Jun-2020

Summary

Official Symbol
JMJD7-PLA2G4Bprovided by HGNC
Official Full Name
JMJD7-PLA2G4B readthroughprovided by HGNC
Primary source
HGNC:HGNC:34449
See related
Ensembl:ENSG00000168970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT16992; cPLA2-beta
Summary
This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]
Annotation information
Note: This geneID was previously used to represent the PLA2G4B locus; however, it is now believed that this gene represents a set of read-through transcripts from the upstream JmjC-domain containing gene (geneID: 100137047) into the separate PLA2G4B gene. Consequently, PLA2G4B is now represented by geneID:100137049. [13 Feb 2013]
Expression
Ubiquitous expression in skin (RPKM 27.8), esophagus (RPKM 12.4) and 24 other tissues See more
Orthologs

Genomic context

See JMJD7-PLA2G4B in Genome Data Viewer
Location:
15q15.1
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41828085..41848148)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42120283..42140346)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MAX dimerization protein MGA Neighboring gene microRNA 626 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 5929 Neighboring gene jumonji domain containing 7 Neighboring gene phospholipase A2 group IVB Neighboring gene RNA, 5S ribosomal pseudogene 393 Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene microRNA 4310

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
JMJD7-PLA2G4B protein
Names
jumonji domain containing 7-phospholipase A2, group IVB (cytosolic) read-through

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029927.1 RefSeqGene

    Range
    5001..25064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198588.1NP_001185517.1  JMJD7-PLA2G4B protein isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as cPLA2 beta2) lacks an alternate exon resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AA064721, AC020659, BC013415, DA096882, DQ523799
    UniProtKB/Swiss-Prot
    P0C869
    Related
    ENSP00000342785.4, ENST00000342159.6
    Conserved Domains (3) summary
    cd04036
    Location:242361
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam13621
    Location:38223
    Cupin_8; Cupin-like domain
    cl11396
    Location:474880
    Patatin_and_cPLA2; Patatins and Phospholipases
  2. NM_005090.3NP_005081.1  JMJD7-PLA2G4B protein isoform a

    See identical proteins and their annotated locations for NP_005081.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as cPLA2 beta) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA064721, AF065215, BI768993, BU688449, DA080158, DA096882
    UniProtKB/Swiss-Prot
    P0C869
    Related
    ENSP00000371886.4, ENST00000382448.8
    Conserved Domains (3) summary
    cd07201
    Location:474999
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:242361
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam13621
    Location:38223
    Cupin_8; Cupin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41828085..41848148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015346.1: Suppressed sequence

    Description
    NR_015346.1: This RefSeq was permanently suppressed because it is incompletely processed.
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