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JMJD7 jumonji domain containing 7 [ Homo sapiens (human) ]

Gene ID: 100137047, updated on 25-Jan-2022

Summary

Official Symbol
JMJD7provided by HGNC
Official Full Name
jumonji domain containing 7provided by HGNC
Primary source
HGNC:HGNC:34397
See related
Ensembl:ENSG00000243789 AllianceGenome:HGNC:34397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 20.1), esophagus (RPKM 12.8) and 25 other tissues See more
Orthologs
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Genomic context

See JMJD7 in Genome Data Viewer
Location:
15q15.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41828092..41837581)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42120290..42129779)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MAX dimerization protein MGA Neighboring gene microRNA 626 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene JMJD7-PLA2G4B readthrough Neighboring gene Sharpr-MPRA regulatory region 5929 Neighboring gene phospholipase A2 group IVB Neighboring gene RNA, 5S ribosomal pseudogene 393 Neighboring gene spectrin beta, non-erythrocytic 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough JMJD7-PLA2G4B

Readthrough gene: JMJD7-PLA2G4B, Included gene: PLA2G4B

Homology

Clone Names

  • FLJ20543, FLJ20656, FLJ20807, FLJ77014, FLJ78330

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-lysine 3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
Names
L-lysine (3S)-hydroxylase JMJD7
jmjC domain-containing protein 7
jumonji domain-containing protein 7
NP_001108104.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114632.2NP_001108104.1  bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7

    See identical proteins and their annotated locations for NP_001108104.1

    Status: VALIDATED

    Source sequence(s)
    AK289833, BC139899, DA100207
    Consensus CDS
    CCDS45240.1
    UniProtKB/Swiss-Prot
    P0C870
    Related
    ENSP00000380467.4, ENST00000397299.9
    Conserved Domains (1) summary
    pfam13621
    Location:38297
    Cupin_8; Cupin-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41828092..41837581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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