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PLA2G4B phospholipase A2 group IVB [ Homo sapiens (human) ]

Gene ID: 100137049, updated on 11-Jun-2021

Summary

Official Symbol
PLA2G4Bprovided by HGNC
Official Full Name
phospholipase A2 group IVBprovided by HGNC
Primary source
HGNC:HGNC:9036
See related
Ensembl:ENSG00000243708 MIM:606088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT16992; cPLA2-beta
Summary
This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 29.6), esophagus (RPKM 11.9) and 23 other tissues See more
Orthologs
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Genomic context

See PLA2G4B in Genome Data Viewer
Location:
15q15.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41838847..41848143)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42131045..42140341)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene JMJD7-PLA2G4B readthrough Neighboring gene Sharpr-MPRA regulatory region 5929 Neighboring gene jumonji domain containing 7 Neighboring gene RNA, 5S ribosomal pseudogene 393 Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene microRNA 4310

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough JMJD7-PLA2G4B

Readthrough gene: JMJD7-PLA2G4B, Included gene: JMJD7

Homology

Clone Names

  • FLJ17693, FLJ42498, FLJ53173, DKFZp686N12131

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding NAS
Non-traceable Author Statement
more info
PubMed 
enables lysophospholipase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables phosphatidyl phospholipase B activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytosolic phospholipase A2 beta
Names
lysophospholipase A1 group IVB
phospholipase A2, group IVB (cytosolic)
NP_001108105.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114633.2NP_001108105.1  cytosolic phospholipase A2 beta

    See identical proteins and their annotated locations for NP_001108105.1

    Status: VALIDATED

    Source sequence(s)
    AK310651, BF372565, BM982475, CA488226, CU447449, DA250544
    Consensus CDS
    CCDS45241.1
    UniProtKB/Swiss-Prot
    P0C869
    Related
    ENSP00000416610.1, ENST00000458483.4
    Conserved Domains (2) summary
    cd07201
    Location:243768
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:11130
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41838847..41848143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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