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YARS tyrosyl-tRNA synthetase [ Homo sapiens (human) ]

Gene ID: 8565, updated on 5-Aug-2018

Summary

Official Symbol
YARSprovided by HGNC
Official Full Name
tyrosyl-tRNA synthetaseprovided by HGNC
Primary source
HGNC:HGNC:12840
See related
Ensembl:ENSG00000134684 MIM:603623; Vega:OTTHUMG00000003933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YRS; YTS; TYRRS; CMTDIC
Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 25.7), brain (RPKM 24.4) and 25 other tissues See more
Orthologs

Genomic context

See YARS in Genome Data Viewer
Location:
1p35.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (32775238..32818032, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33240840..33283633, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RB binding protein 4, chromatin remodeling factor Neighboring gene syncoilin, intermediate filament protein Neighboring gene KIAA1522 Neighboring gene S100P binding protein Neighboring gene uncharacterized LOC105378631 Neighboring gene fibronectin type III domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tyrosyl-tRNA synthetase (YARS) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tyrosyl-tRNA synthetase in T-cell lines PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
interleukin-8 receptor binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tyrosine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tyrosine-tRNA ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
tRNA aminoacylation for protein translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
tyrosyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
methionyl glutamyl tRNA synthetase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tyrosine--tRNA ligase, cytoplasmic
Names
tyrosine tRNA ligase 1, cytoplasmic
tyrosyl--tRNA ligase
tyrosyl-tRNA synthetase, cytoplasmic
NP_003671.1
XP_011540649.1
XP_011540650.1
XP_016858140.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008408.1 RefSeqGene

    Range
    5001..47794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_273

mRNA and Protein(s)

  1. NM_003680.3NP_003671.1  tyrosine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_003671.1

    Status: REVIEWED

    Source sequence(s)
    AC114489, AC114493
    Consensus CDS
    CCDS368.1
    UniProtKB/Swiss-Prot
    P54577
    UniProtKB/TrEMBL
    A0A0S2Z4R1
    Related
    ENSP00000362576.4, OTTHUMP00000004027, ENST00000373477.8, OTTHUMT00000011225
    Conserved Domains (2) summary
    cl00015
    Location:8328
    nt_trans; nucleotidyl transferase superfamily
    cl26127
    Location:327528
    PRK12267; methionyl-tRNA synthetase; Reviewed

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    32775238..32818032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542347.2XP_011540649.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_011540649.1

    Conserved Domains (2) summary
    cd02799
    Location:153258
    tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
    cl00015
    Location:4128
    nt_trans; nucleotidyl transferase superfamily
  2. XM_017002651.2XP_016858140.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

    Conserved Domains (2) summary
    cd02799
    Location:153258
    tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
    cl00015
    Location:4128
    nt_trans; nucleotidyl transferase superfamily
  3. XM_011542348.1XP_011540650.1  tyrosine--tRNA ligase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_011540650.1

    Conserved Domains (2) summary
    cd02799
    Location:153258
    tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
    cl00015
    Location:4128
    nt_trans; nucleotidyl transferase superfamily
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