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SSH2 slingshot protein phosphatase 2 [ Homo sapiens (human) ]

Gene ID: 85464, updated on 7-Dec-2018

Summary

Official Symbol
SSH2provided by HGNC
Official Full Name
slingshot protein phosphatase 2provided by HGNC
Primary source
HGNC:HGNC:30580
See related
Ensembl:ENSG00000141298 MIM:606779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSH-2; SSH-2L
Summary
This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Broad expression in lymph node (RPKM 6.2), appendix (RPKM 6.0) and 24 other tissues See more
Orthologs

Genomic context

See SSH2 in Genome Data Viewer
Location:
17q11.2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (29625938..29930239, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27952956..28257231, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 13B Neighboring gene GIT ArfGAP 1 Neighboring gene uncharacterized LOC107984990 Neighboring gene RNA, U6 small nuclear 920, pseudogene Neighboring gene coronin 6 Neighboring gene VISTA enhancer hs1675 Neighboring gene ribosomal protein L21 pseudogene 123 Neighboring gene RNA terminal phosphate cyclase like 1 pseudogene Neighboring gene ribosomal protein L9 pseudogene 30 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene RNY4 pseudogene 13 Neighboring gene syntaxin 18 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1725, MGC78588

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular space HDA PubMed 

General protein information

Preferred Names
protein phosphatase Slingshot homolog 2
Names
SSH-like protein 2
NP_001269058.1
NP_001269059.1
NP_001269060.1
NP_203747.2
XP_005258115.1
XP_005258116.1
XP_005258117.1
XP_006722212.1
XP_011523704.1
XP_011523706.1
XP_011523707.1
XP_011523708.1
XP_011523709.1
XP_016880740.1
XP_016880741.1
XP_016880742.1
XP_016880743.1
XP_016880744.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282129.2NP_001269058.1  protein phosphatase Slingshot homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001269058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB099290, AC104982, AI609950, AK296413, DA749059
    Consensus CDS
    CCDS74024.1
    UniProtKB/Swiss-Prot
    Q76I76
    UniProtKB/TrEMBL
    B4DK64, F5H527
    Related
    ENSP00000444743.1, ENST00000540801.5
    Conserved Domains (3) summary
    cd11652
    Location:38263
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:335470
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:278329
    DEK_C; DEK C terminal domain
  2. NM_001282130.1NP_001269059.1  protein phosphatase Slingshot homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001269059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple coding exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC104982, BC008941, DA749059
    UniProtKB/Swiss-Prot
    Q76I76
    Conserved Domains (1) summary
    cd11652
    Location:3178
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
  3. NM_001282131.1NP_001269060.1  protein phosphatase Slingshot homolog 2 isoform 4

    See identical proteins and their annotated locations for NP_001269060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 5' and 3' coding exons. It represents use of an internal promoter and initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has distinct N- and C- termini, compared to isoform 1.
    Source sequence(s)
    BC008941, BC011636, DA861985
    UniProtKB/Swiss-Prot
    Q76I76
    Related
    ENSP00000497894.1, ENST00000324677.12
    Conserved Domains (1) summary
    cd11652
    Location:37185
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
  4. NM_033389.3NP_203747.2  protein phosphatase Slingshot homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_203747.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB099290, AC104564, AI609950, DA749059
    Consensus CDS
    CCDS11253.1
    UniProtKB/Swiss-Prot
    Q76I76
    Related
    ENSP00000269033.3, ENST00000269033.7
    Conserved Domains (3) summary
    cd11652
    Location:3236
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:308443
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:251302
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    29625938..29930239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258058.3XP_005258115.1  protein phosphatase Slingshot homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_005258115.1

    UniProtKB/TrEMBL
    F5H527
    Conserved Domains (3) summary
    cd11652
    Location:38263
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:335470
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:278329
    DEK_C; DEK C terminal domain
  2. XM_017025252.1XP_016880741.1  protein phosphatase Slingshot homolog 2 isoform X9

  3. XM_017025251.2XP_016880740.1  protein phosphatase Slingshot homolog 2 isoform X2

  4. XM_011525402.2XP_011523704.1  protein phosphatase Slingshot homolog 2 isoform X3

    Conserved Domains (3) summary
    cd11652
    Location:18243
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:315450
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:258309
    DEK_C; DEK C terminal domain
  5. XM_011525407.1XP_011523709.1  protein phosphatase Slingshot homolog 2 isoform X8

    See identical proteins and their annotated locations for XP_011523709.1

    Conserved Domains (3) summary
    cd11652
    Location:17160
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:232367
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:175226
    DEK_C; DEK C terminal domain
  6. XM_011525406.2XP_011523708.1  protein phosphatase Slingshot homolog 2 isoform X8

    See identical proteins and their annotated locations for XP_011523708.1

    Conserved Domains (3) summary
    cd11652
    Location:17160
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:232367
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:175226
    DEK_C; DEK C terminal domain
  7. XM_011525405.2XP_011523707.1  protein phosphatase Slingshot homolog 2 isoform X7

    Conserved Domains (3) summary
    cd11652
    Location:8207
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:279414
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:222273
    DEK_C; DEK C terminal domain
  8. XM_006722149.4XP_006722212.1  protein phosphatase Slingshot homolog 2 isoform X6

    Conserved Domains (3) summary
    cd11652
    Location:14214
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:286421
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:229280
    DEK_C; DEK C terminal domain
  9. XM_011525404.2XP_011523706.1  protein phosphatase Slingshot homolog 2 isoform X5

    Conserved Domains (3) summary
    cd11652
    Location:18218
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:290425
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:233284
    DEK_C; DEK C terminal domain
  10. XM_005258060.3XP_005258117.1  protein phosphatase Slingshot homolog 2 isoform X10

  11. XM_005258059.2XP_005258116.1  protein phosphatase Slingshot homolog 2 isoform X4

    See identical proteins and their annotated locations for XP_005258116.1

    Related
    ENSP00000497148.1, ENST00000649863.1
    Conserved Domains (3) summary
    cd11652
    Location:37243
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:315450
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:258309
    DEK_C; DEK C terminal domain
  12. XM_017025254.2XP_016880743.1  protein phosphatase Slingshot homolog 2 isoform X12

  13. XM_017025253.2XP_016880742.1  protein phosphatase Slingshot homolog 2 isoform X11

  14. XM_017025255.2XP_016880744.1  protein phosphatase Slingshot homolog 2 isoform X13

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