Conserved Protein Domain Family
SSH-N

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cd11652: SSH-N 
N-terminal domain conserved in slingshot (SSH) phosphatases
This domain or region conserved in Bilateria is found N-terminal to the DEK_C-like and catalytic domains of slingshot phosphatases. Slingshot is a cofilin-specific phosphatase. Dephosphorylation reactivates cofilin, which in turn depolymerizes actin and is thus required for actin filament reorganization. Slingshot is a member of the dual-specificity protein phosphatase family. This N-terminal SSH region may be involved in P-cofilin binding (the model C-terminus plus the DEK_C-like domain, which are characterized as the "B" domain in some of the literature), and may be required for the F-actin mediated activation of slingshot (the N-terminal region of this model, sometimes referred to as the "A" domain).
Links
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Source: Cdd
Taxonomy: Bilateria
PubMed: 16 links
Book:
Protein: Representatives
Specific Protein
Related Protein
Related Structure
Architectures
Superfamily: cl17009
BioSystems: 275 links
Statistics
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PSSM-Id: 212166
View PSSM: cd11652
Aligned: 15 rows
Threshold Bit Score: 326.991
Threshold Setting Gi: 239582767
Created: 14-Mar-2012
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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PubMed ReferencesClick to see Conserved Features Help

cd11652 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd11652 is the only member of the superfamily cl17009
cd11652:SSH-N3245070953120831728258226927001401732726052623958276747215538825822702053609643637413388258226730160493226079126319842032911575713632450709531208317282582269270014017327260526239582767472155388258227020536096436374133882582267301604932260791263198420329115757136
cd11652 Sequence Cluster
cd11652 Sequence Cluster
Sub-family Hierarchy
Click to see CD Hierarchy help
CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82582269     3 LVTVQRSPSVAGSCsnsd-----------geseDDEGNSKGNDRSECFFAGKGTALVLALKDIPpltqserrls------ 65
gi 301604932    3 LVTLQRSPTPSATSsasts----------eefgNEEDRKVNLSLSDSFFMVKGAALFLQQGNSTqgqrs----------- 61
gi 327260526    3 LVTVCRSPSGSGHStptg------------gkdEEVSRRRQMQRRHSFVMVKGAALLLQEEEKLesvqegssap------ 64
gi 260791263    3 LVTVQRSPTPSNSGsssgsve------daddesEEKRLKRTHSLCESYVAIKDCVLILPQSDNVqrp------------- 63
gi 239582767    3 LVTVSRSPPGSGAStpvg------------pwdQAVQRRSRLQRRQSFAVLRGAVLGLQDGGDNddaaeasseptekaps 70
gi 198420329   14 STQYIRQPMVDENRnyrtgntasgdamhdedggNVVEVQPVLPWRNSRHSDVSMRVMLKTHDSQf--------------- 78
gi 115757136  190 SVTNTYTWPVYGPLlafgicl------clvhdnDDEAEERLKRGCESFFAMKGAAIVLPHSKDTkrp------------- 250
gi 82582270     3 LVTLQVSSLDVGSNitp-------------vqdDEKSRRKRMQRRQSFVMVKGAALLLQDEGEPidtr------------ 57
gi 324507095    3 LVTVQRSPTPSENAnfdhsda------dvcecgLSPRKSKSVASSECFFYVKGTAVILLNHDRTnv-------------- 62
gi 270014017   13 LKTVLLRLPAVGARva----------------lLHNWNKNYKGLSECYFAGKGTALVLPAAEAQksn------------- 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82582269    66 -------tdstrssnstQSNNSDIQLHLQSMFYLLQREDTLKMAVKLESQRSNRTRYLVIASRSCcrsgtsdrrrhrimr 138
gi 301604932   62 -------------llnlHKHAGDLPQHLQLMINLLRCEDRIKLAVRLESNWTDRVRYMVVVYCNGr-------------- 114
gi 327260526   65 -------idqgeevkseSTGAGQQEVHLQQMVGLLRPEDTIRLAVRLESTRAHRIRYLVVVSAAEm-------------- 123
gi 260791263   64 ---------------arSTRGGDLQNHLQSMFYLLRPQDTIKLAVKLESAYPDRIRYMAIVSCFGr-------------- 114
gi 239582767   71 eeelhgdqtdfgqgsqsPQKQEEQRQHLHLMVQLLRPQDDIRLAAQLEAPRPPRLRYLLVVSTREge------------- 137
gi 198420329   79 -----------------KLPAGELQTHLHAIFHHLRPQDSIKLAVRLESWVEEHRRYLVIVTTTGr-------------- 127
gi 115757136  251 --------------ikkHPVVGELQQHLQCIFWILRPEDTIKMAVRLESSSDNTIRYMVLVSCLDth------------- 303
gi 82582270    58 -------------eplsSSGPNEQQIHLQSMLRLLREEDTLTLAVRLEPVRSCLTRYLLVVSSTGk-------------- 110
gi 324507095   63 ---------------ahNSANGEIEEHLQAMLRMLPPEDTLTMAVRLQPNSDQDCLQDHARYLAVvasssrq-------- 119
gi 270014017   64 --------------rrtDAQGSNIRKHLQSIVDLLRPEETLKMAVKLESVHASRVRYLVIVSRMGk-------------- 115
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82582269   139 hhsvkvggsagtksstspavptqrqlsveqtateasskcdktadkenataagdnkntsGMEESCLLGIDCNER----TTI 214
gi 301604932  115 ---------------------------------------------------------qDTEENILLGVDFTNKesksCTI 137
gi 327260526  124 ---------------------------------------------------------eRKNEMVLLGVDFPEEglagCTL 146
gi 260791263  115 ---------------------------------------------------------eDTEESIILGIDFQDRqs-eASV 136
gi 239582767  138 --------------------------------------------------------glSQDETVLLGVDFPDSsspsCTL 161
gi 198420329  128 ---------------------------------------------------------qDTEENIIVGCDFATKestsCTI 150
gi 115757136  304 ---------------------------------------------------------qNTEETIILGMDIIQNk---ATI 323
gi 82582270   111 ---------------------------------------------------------sNVEETLLLGVDFPHDgslcCTI 133
gi 324507095  120 ----------------------------------------------------diddsrDARECVLLGLDCLPGd--kATI 145
gi 270014017  116 ----------------------------------------------------------RGEESCLLGIDCNEK----TTV 133
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82582269   215 GLVVPILADTTIHLDGDGGFSVKVyEKTHIFKPVSVQAMWSALQTLHKVSKKARENNFYASGp---SHDWLSSYERRIES 291
gi 301604932  138 GMVLHLWSDTKIHLDGDGGFSVNTaGKTHVFKPVSVQAMWSALQVLHKACEVARRFNYFPGGl---SLVWATYYESCISS 214
gi 327260526  147 GMVLPLWSDTQVFLDGDGGFSVTSgGQTRIFKPISVQTMWSALQVLHKACGDAVCNNYFPGGs---ALSWTEWYQKAVNS 223
gi 260791263  137 GLVLPIWSNTKVTLDGDGGFSVSShGRYFIFKPVSVQAMWSALQSLHKVAAIAREYNYFDGSi---FLTWTGYYSNRISS 213
gi 239582767  162 GLVLPLWSDTQVYLDGDGGFSVTSgGQSRIFKPISIQTMWATLQVLHQACEAALGSGLVPGGs---ALTWASHYQERLNS 238
gi 198420329  151 GLVLPIWCDTSIQLDGDGGFKVLShEKTHTFKPVSVQAMWSALQSLHRCKDTALRHNYYEGSl---YLTWTCFYASRVAS 227
gi 115757136  324 GLVLPIWADSIIQMDGDGGFSVTTgEKINVFKPVSIQAMWSALQALYRACNLARVHNYFIGGl---HMTWIGFYQSSVSS 400
gi 82582270   134 GTVLPIWSNTQVFLDGDGGFTVTSgMDIRTFKPISVQTMWSLLQMLHKACESALSNNVISSS----LYSGLIYYQSNRSS 209
gi 324507095  146 GVVIPIFASTHVRLDGDGGIAVDCdSSYHLFRPVSVQAMWTMFQCLHKELREVQGAKNSPSQtarpGERLVDYYLRHISS 225
gi 270014017  134 GLVLKVMADTAIRLDGDGGFSVSVcGRHHIFKPVSVQAMWSALQTLHKVSSKAREQNYFQGGl---THDWVEYYEKRIES 210
                         330       340
                  ....*....|....*....|.
gi 82582269   292 DQSCLNEWNAMDALESRRPPS 312
gi 301604932  215 EQSCINEWNTMQDLESARADS 235
gi 327260526  224 EQSCINEWLAMADLESVRPSS 244
gi 260791263  214 NQSCVKEWHVLDDLMCHRPES 234
gi 239582767  239 EQSCLNEWTAMADLESLRPPS 259
gi 198420329  228 NRININEWEYSEDLWSRKPNY 248
gi 115757136  401 PYYCLKEWEYLPDMTSPQSDE 421
gi 82582270   210 PQVCLNAWTASPDIESARRDP 230
gi 324507095  226 QDAIRAEWERSSSEYGIGTSS 246
gi 270014017  211 DRSCLNEWHAMDNLESKRPPS 231
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