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ZFHX2 zinc finger homeobox 2 [ Homo sapiens (human) ]

Gene ID: 85446, updated on 1-Aug-2020

Summary

Official Symbol
ZFHX2provided by HGNC
Official Full Name
zinc finger homeobox 2provided by HGNC
Primary source
HGNC:HGNC:20152
See related
Ensembl:ENSG00000136367 MIM:617828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFH5; ZFH-5; MARSIS; ZNF409
Expression
Biased expression in testis (RPKM 3.0), brain (RPKM 0.7) and 5 other tissues See more
Orthologs

Genomic context

See ZFHX2 in Genome Data Viewer
Location:
14q11.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (23520857..23556315, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23990064..24025199, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2330 Neighboring gene neuroguidin Neighboring gene thiamine triphosphatase Neighboring gene uncharacterized LOC102724814 Neighboring gene adaptor related protein complex 1 subunit gamma 2 Neighboring gene junctophilin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17566, FLJ42478, KIAA1056, KIAA1762, MGC141820

Gene Ontology Provided by GOA

Process Evidence Code Pubs
adult behavior IEA
Inferred from Electronic Annotation
more info
 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger homeobox protein 2
Names
ZFH-2
zinc finger homeodomain protein 2
zinc finger protein 409

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033400.3NP_207646.2  zinc finger homeobox protein 2

    See identical proteins and their annotated locations for NP_207646.2

    Status: VALIDATED

    Source sequence(s)
    AB028979, AB051549, AI093184, AL132855, AL135999, BC144336, BC150606
    Consensus CDS
    CCDS55907.1
    UniProtKB/Swiss-Prot
    Q9C0A1
    UniProtKB/TrEMBL
    B7ZM83, B9EK48
    Related
    ENSP00000413418.2, ENST00000419474.5
    Conserved Domains (6) summary
    cd00086
    Location:18581916
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:11931215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24532496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20692121
    Homeobox; Homeobox domain
    pfam13909
    Location:508532
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl26464
    Location:22072365
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    23520857..23556315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021715.2XP_016877204.1  zinc finger homeobox protein 2 isoform X2

  2. XM_011537245.3XP_011535547.1  zinc finger homeobox protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535547.1

    UniProtKB/Swiss-Prot
    Q9C0A1
    Conserved Domains (6) summary
    cd00086
    Location:18581916
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:11931215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24532496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20692121
    Homeobox; Homeobox domain
    pfam13909
    Location:508532
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl26464
    Location:22072365
    Atrophin-1; Atrophin-1 family
  3. XM_017021714.1XP_016877203.1  zinc finger homeobox protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9C0A1
    Conserved Domains (6) summary
    cd00086
    Location:18581916
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:11931215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24532496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20692121
    Homeobox; Homeobox domain
    pfam13909
    Location:508532
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl26464
    Location:22072365
    Atrophin-1; Atrophin-1 family
  4. XM_011537246.3XP_011535548.1  zinc finger homeobox protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535548.1

    UniProtKB/Swiss-Prot
    Q9C0A1
    Conserved Domains (6) summary
    cd00086
    Location:18581916
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:11931215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24532496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20692121
    Homeobox; Homeobox domain
    pfam13909
    Location:508532
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl26464
    Location:22072365
    Atrophin-1; Atrophin-1 family
  5. XM_011537247.2XP_011535549.1  zinc finger homeobox protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535549.1

    UniProtKB/Swiss-Prot
    Q9C0A1
    Conserved Domains (6) summary
    cd00086
    Location:18581916
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:11931215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24532496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20692121
    Homeobox; Homeobox domain
    pfam13909
    Location:508532
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl26464
    Location:22072365
    Atrophin-1; Atrophin-1 family
  6. XM_017021716.2XP_016877205.1  zinc finger homeobox protein 2 isoform X3

  7. XM_017021718.2XP_016877207.1  zinc finger homeobox protein 2 isoform X5

    Conserved Domains (4) summary
    cd00086
    Location:808866
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:143165
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14031446
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:10191071
    Homeobox; Homeobox domain
  8. XM_005268135.3XP_005268192.1  zinc finger homeobox protein 2 isoform X4

    See identical proteins and their annotated locations for XP_005268192.1

    Conserved Domains (4) summary
    cd00086
    Location:888946
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:223245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14831526
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:10991151
    Homeobox; Homeobox domain
  9. XM_011537252.2XP_011535554.1  zinc finger homeobox protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011535554.1

    Conserved Domains (4) summary
    cd00086
    Location:888946
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:223245
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:14831526
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:10991151
    Homeobox; Homeobox domain
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