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Zfhx2 zinc finger homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 239102, updated on 26-Sep-2022

Summary

Official Symbol
Zfhx2provided by MGI
Official Full Name
zinc finger homeobox 2provided by MGI
Primary source
MGI:MGI:2686934
See related
Ensembl:ENSMUSG00000040721 AllianceGenome:MGI:2686934
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZFH-5
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of sensory perception of pain. Acts upstream of or within adult behavior. Located in nucleus. Is expressed in several structures, including gut; male reproductive system; musculature; nervous system; and urinary system. Orthologous to human ZFHX2 (zinc finger homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 11.4), CNS E14 (RPKM 7.0) and 15 other tissues See more
Orthologs
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Genomic context

See Zfhx2 in Genome Data Viewer
Location:
14; 14 C3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55297722..55329875, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55060268..55092381, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene neuroguidin, EIF4E binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene zinc finger homeobox 2, opposite strand Neighboring gene thiamine triphosphatase Neighboring gene adaptor protein complex AP-1, gamma 2 subunit Neighboring gene junctophilin 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger homeobox protein 2
Names
zinc finger homeodomain protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039198.1NP_001034287.1  zinc finger homeobox protein 2

    See identical proteins and their annotated locations for NP_001034287.1

    Status: PROVISIONAL

    Source sequence(s)
    AB190186
    Consensus CDS
    CCDS27107.1
    UniProtKB/Swiss-Prot
    Q80VJ9
    UniProtKB/TrEMBL
    Q2MHN3
    Related
    ENSMUSP00000045156.9, ENSMUST00000036328.9
    Conserved Domains (7) summary
    cd00086
    Location:18521910
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    sd00017
    Location:11871209
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24432486
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20622114
    Homeobox; Homeobox domain
    pfam13909
    Location:501525
    zf-H2C2_5; C2H2-type zinc-finger domain
    cl26464
    Location:21862300
    Atrophin-1; Atrophin-1 family
    cl27820
    Location:18181944
    Abdominal-A; Homeobox protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55297722..55329875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316015.3XP_017171504.1  zinc finger homeobox protein 2 isoform X3

    Conserved Domains (6) summary
    PHA03247
    Location:21562270
    PHA03247; large tegument protein UL36; Provisional
    COG5576
    Location:17881914
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:11571179
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24132456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20322085
    Homeobox; Homeobox domain
    pfam13909
    Location:501525
    zf-H2C2_5; C2H2-type zinc-finger domain
  2. XM_030247796.2XP_030103656.1  zinc finger homeobox protein 2 isoform X2

    Conserved Domains (6) summary
    PHA03247
    Location:21662280
    PHA03247; large tegument protein UL36; Provisional
    COG5576
    Location:17981924
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:11671189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24232466
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20422095
    Homeobox; Homeobox domain
    pfam13909
    Location:501525
    zf-H2C2_5; C2H2-type zinc-finger domain
  3. XM_011245060.4XP_011243362.3  zinc finger homeobox protein 2 isoform X1

    Conserved Domains (6) summary
    PHA03247
    Location:21962310
    PHA03247; large tegument protein UL36; Provisional
    COG5576
    Location:18281954
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:11971219
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:24532496
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:20722125
    Homeobox; Homeobox domain
    pfam13909
    Location:501525
    zf-H2C2_5; C2H2-type zinc-finger domain