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CAMK1 calcium/calmodulin dependent protein kinase I [ Homo sapiens (human) ]

Gene ID: 8536, updated on 7-Dec-2018

Summary

Official Symbol
CAMK1provided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase Iprovided by HGNC
Primary source
HGNC:HGNC:1459
See related
Ensembl:ENSG00000134072 MIM:604998
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAMKI
Summary
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]
Expression
Broad expression in adrenal (RPKM 42.3), fat (RPKM 25.3) and 22 other tissues See more
Orthologs

Genomic context

See CAMK1 in Genome Data Viewer
Location:
3p25.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (9757345..9769987, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9799029..9811676, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene copine family member 9 Neighboring gene bromodomain and PHD finger containing 1 Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene transcriptional adaptor 3 Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed
tat Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including CAMK1, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
    Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
    Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
    Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC120317, MGC120318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synapse structural plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of syncytium formation by plasma membrane fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of histone H3-K9 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type 1
Names
caM kinase I alpha
caM-KI
caMKI-alpha
NP_003647.1
XP_005265573.1
XP_005265574.1
XP_016862843.1
XP_024309564.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003656.5NP_003647.1  calcium/calmodulin-dependent protein kinase type 1

    See identical proteins and their annotated locations for NP_003647.1

    Status: REVIEWED

    Source sequence(s)
    AA724193, BC106754, DN990042
    Consensus CDS
    CCDS2582.1
    UniProtKB/Swiss-Prot
    Q14012
    UniProtKB/TrEMBL
    B0YIY3
    Related
    ENSP00000256460.3, ENST00000256460.7
    Conserved Domains (1) summary
    cd14167
    Location:16278
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    9757345..9769987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007354.1XP_016862843.1  calcium/calmodulin-dependent protein kinase type 1 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:8232
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:16234
    PKc_like; Protein Kinases, catalytic domain
  2. XM_005265517.3XP_005265574.1  calcium/calmodulin-dependent protein kinase type 1 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:8232
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:16231
    PKc_like; Protein Kinases, catalytic domain
  3. XM_024453796.1XP_024309564.1  calcium/calmodulin-dependent protein kinase type 1 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1216
    PKc_like; Protein Kinases, catalytic domain
  4. XM_005265516.2XP_005265573.1  calcium/calmodulin-dependent protein kinase type 1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:20276
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14167
    Location:16278
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

RNA

  1. XR_940505.2 RNA Sequence

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