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Camk1 calcium/calmodulin-dependent protein kinase I [ Mus musculus (house mouse) ]

Gene ID: 52163, updated on 27-Nov-2024

Summary

Official Symbol
Camk1provided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase Iprovided by MGI
Primary source
MGI:MGI:1098535
See related
Ensembl:ENSMUSG00000030272 AllianceGenome:MGI:1098535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Camk; CaMKIalpha; D6Ertd263e
Summary
Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Acts upstream of or within several processes, including nucleocytoplasmic transport; positive regulation of protein export from nucleus; and protein phosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including bone; cardiovascular system; genitourinary system; nervous system; and retina. Orthologous to human CAMK1 (calcium/calmodulin dependent protein kinase I). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 35.3), frontal lobe adult (RPKM 32.7) and 27 other tissues See more
Orthologs
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Genomic context

See Camk1 in Genome Data Viewer
Location:
6 E3; 6 52.75 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113311085..113320883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113334124..113343922, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene copine family member IX Neighboring gene STARR-seq mESC enhancer starr_17036 Neighboring gene STARR-positive B cell enhancer ABC_E237 Neighboring gene bromodomain and PHD finger containing, 1 Neighboring gene STARR-positive B cell enhancer ABC_E1326 Neighboring gene 8-oxoguanine DNA-glycosylase 1 Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene Neighboring gene transcriptional adaptor 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium/calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium/calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleocytoplasmic transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synapse structural plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse structural plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of syncytium formation by plasma membrane fusion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of syncytium formation by plasma membrane fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type 1
Names
caM kinase I alpha
caM-KI
caMKI-alpha
NP_598687.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133926.2NP_598687.1  calcium/calmodulin-dependent protein kinase type 1

    See identical proteins and their annotated locations for NP_598687.1

    Status: VALIDATED

    Source sequence(s)
    AC155287
    Consensus CDS
    CCDS20415.1
    UniProtKB/Swiss-Prot
    Q91YS8
    UniProtKB/TrEMBL
    Q3UY68
    Related
    ENSMUSP00000032409.9, ENSMUST00000032409.15
    Conserved Domains (1) summary
    cd14167
    Location:16278
    STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113311085..113320883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)