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DDO D-aspartate oxidase [ Homo sapiens (human) ]

Gene ID: 8528, updated on 11-Sep-2019

Summary

Official Symbol
DDOprovided by HGNC
Official Full Name
D-aspartate oxidaseprovided by HGNC
Primary source
HGNC:HGNC:2727
See related
Ensembl:ENSG00000203797 MIM:124450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DASOX; DDO-1; DDO-2
Summary
The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2019]
Expression
Broad expression in heart (RPKM 7.9), kidney (RPKM 5.9) and 20 other tissues See more
Orthologs

Genomic context

See DDO in Genome Data Viewer
Location:
6q21
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (110388321..110415575, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110709545..110736839, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377937 Neighboring gene methyltransferase like 24 Neighboring gene uncharacterized LOC102724586 Neighboring gene uncharacterized LOC105377936 Neighboring gene solute carrier family 22 member 16 Neighboring gene RNA, 7SL, cytoplasmic 617, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of D-aspartate oxidase (DDO) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Alanine, aspartate and glutamate metabolism, organism-specific biosystem (from KEGG)
    Alanine, aspartate and glutamate metabolism, organism-specific biosystem
    Alanine, aspartate and glutamate metabolism
  • Alanine, aspartate and glutamate metabolism, conserved biosystem (from KEGG)
    Alanine, aspartate and glutamate metabolism, conserved biosystem
    Alanine, aspartate and glutamate metabolism
  • Glyoxylate metabolism and glycine degradation, organism-specific biosystem (from REACTOME)
    Glyoxylate metabolism and glycine degradation, organism-specific biosystemGlyoxylate is generated in the course of glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver. Defects in two enzymes of glyoxylate ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45203

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-amino-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
D-aspartate oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
D-aspartate oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
FAD binding IEA
Inferred from Electronic Annotation
more info
 
cofactor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
D-amino acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
D-amino acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
aspartate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aspartate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
grooming behavior IEA
Inferred from Electronic Annotation
more info
 
hormone metabolic process IEA
Inferred from Electronic Annotation
more info
 
insemination IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisome NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
D-aspartate oxidase
Names
D-aspartate oxidase, DDO
aspartic oxidase
NP_001355099.1
NP_001355100.1
NP_001355101.1
NP_001355102.1
NP_001355103.1
NP_001355104.1
NP_001359037.1
NP_004023.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368170.1NP_001355099.1  D-aspartate oxidase isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050350
  2. NM_001368171.1NP_001355100.1  D-aspartate oxidase isoform d

    Status: REVIEWED

    Source sequence(s)
    AL050350
  3. NM_001368172.1NP_001355101.1  D-aspartate oxidase isoform e

    Status: REVIEWED

    Source sequence(s)
    AL050350
  4. NM_001368173.1NP_001355102.1  D-aspartate oxidase isoform f

    Status: REVIEWED

    Source sequence(s)
    AL050350
  5. NM_001368174.1NP_001355103.1  D-aspartate oxidase isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 8 and 9, encodes isoform g.
    Source sequence(s)
    AL050350
  6. NM_001368175.1NP_001355104.1  D-aspartate oxidase isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 7 and 9, encodes isoform g.
    Source sequence(s)
    AL050350
  7. NM_001372108.1NP_001359037.1  D-aspartate oxidase isoform h

    Status: REVIEWED

    Source sequence(s)
    AL050350, BC032786
    Consensus CDS
    CCDS5082.1
  8. NM_004032.3NP_004023.3  D-aspartate oxidase isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL050350
    Consensus CDS
    CCDS5083.1
    Related
    ENSP00000357919.3, ENST00000368923.7

RNA

  1. NR_160546.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL050350

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    110388321..110415575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003649.3: Suppressed sequence

    Description
    NM_003649.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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