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METTL24 methyltransferase like 24 [ Homo sapiens (human) ]

Gene ID: 728464, updated on 23-Nov-2021

Summary

Official Symbol
METTL24provided by HGNC
Official Full Name
methyltransferase like 24provided by HGNC
Primary source
HGNC:HGNC:21566
See related
Ensembl:ENSG00000053328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf186
Expression
Broad expression in endometrium (RPKM 3.7), gall bladder (RPKM 2.6) and 20 other tissues See more
Orthologs
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Genomic context

See METTL24 in Genome Data Viewer
Location:
6q21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (110243940..110358349, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110565143..110679552, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene WASP family member 1 Neighboring gene cell division cycle 40 Neighboring gene uncharacterized LOC105377937 Neighboring gene uncharacterized LOC102724586 Neighboring gene Sharpr-MPRA regulatory region 3191 Neighboring gene D-aspartate oxidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included genes: DDO, WASF1

Homology

Clone Names

  • FLJ45203

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable methyltransferase-like protein 24
Names
UPF0624 protein C6orf186
methyltransferase-like protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123364.3NP_001116836.1  probable methyltransferase-like protein 24 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001116836.1

    Status: VALIDATED

    Source sequence(s)
    AL050350, AL445068
    Consensus CDS
    CCDS43489.1
    UniProtKB/Swiss-Prot
    Q5JXM2
    Related
    ENSP00000344071.4, ENST00000338882.5
    Conserved Domains (1) summary
    cl17173
    Location:248298
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001354594.2NP_001341523.1  probable methyltransferase-like protein 24 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL050350, AL445068
    Conserved Domains (1) summary
    cl17173
    Location:51101
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_001354595.2NP_001341524.1  probable methyltransferase-like protein 24 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL050350, AL445068
    Conserved Domains (1) summary
    cl17173
    Location:51101
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    110243940..110358349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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