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Ddo D-aspartate oxidase [ Mus musculus (house mouse) ]

Gene ID: 70503, updated on 25-Jan-2023

Summary

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Official Symbol
Ddoprovided by MGI
Official Full Name
D-aspartate oxidaseprovided by MGI
Primary source
MGI:MGI:1925528
See related
Ensembl:ENSMUSG00000063428 AllianceGenome:MGI:1925528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5330420D20Rik; 5730402C02Rik
Summary
Enables D-aspartate oxidase activity and FAD binding activity. Involved in D-amino acid catabolic process. Acts upstream of or within several processes, including aspartate metabolic process; grooming behavior; and insemination. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; chordamesoderm; nervous system; respiratory system; and sensory organ. Orthologous to human DDO (D-aspartate oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 4.3), heart adult (RPKM 4.1) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Ddo in Genome Data Viewer
Location:
10; 10 B1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40505933..40557847)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40630011..40681847)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17795 Neighboring gene solute carrier family 22 (organic cation transporter), member 16 Neighboring gene methyltransferase like 24 Neighboring gene cell division cycle 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity. Nuzzo T, et al. Exp Neurol, 2019 Jul. PMID 30822420
  2. Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene. Florio E, et al. Epigenetics, 2017 Jan 2. PMID 27858532, Free PMC Article
  3. Higher free D-aspartate and N-methyl-D-aspartate levels prevent striatal depotentiation and anticipate L-DOPA-induced dyskinesia. Errico F, et al. Exp Neurol, 2011 Dec. PMID 21946266
  4. Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase. Katane M, et al. Amino Acids, 2011 Feb. PMID 20567862
  5. Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay. Errico F, et al. Neurobiol Aging, 2011 Nov. PMID 20031274

See all (31) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans.
    Title: D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans.
  2. Prenatal expression of D-aspartate oxidase causes early cerebral D-aspartate depletion and influences brain morphology and cognitive functions at adulthood.
    Title: Prenatal expression of D-aspartate oxidase causes early cerebral D-aspartate depletion and influences brain morphology and cognitive functions at adulthood.
  3. In this framework, an epiallele is defined as a specific combination of methylated CpG within Ddo locus and can represent the epigenetic haplotype revealing a cell-to-cell methylation heterogeneity.
    Title: Tracking the evolution of epialleles during neural differentiation and brain development: D-Aspartate oxidase as a model gene.
  4. This study demonstraed that age-related reduction of free d-Asp levels in the mouse brain in dod knockout mice.
    Title: Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.
  5. Ddo(-/-) mice display a significant reduction in schizophrenia related symptoms induced by phencyclidine. Increased D-aspartate in Ddo(-/-) animals affect the development of cortico-hippocampal connectivity networks potentially involved in schizophrenia.
    Title: A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice.
  6. Arg-216 and Arg-237 play crucial roles in the substrate specificity of DDO.
    Title: Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase.
  7. reports that the behavioral phenotype of the Dco-/- mouse is characterized by deficits in prepulse inhibition of the acoustic startle reflex and in motor coordination on the RotoRod
    Title: Behavioural alterations in male mice lacking the gene for D-aspartate oxidase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-amino-acid oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables D-aspartate oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-aspartate oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-amino acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in D-amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aspartate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in aspartate catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within aspartate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within grooming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within insemination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-aspartate oxidase
Names
DASOX
NP_001303645.1
NP_001303646.1
NP_001303647.1
NP_001303648.1
NP_081718.2
XP_036011895.1
XP_036011896.1
XP_036011897.1
XP_036011898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316716.2 → NP_001303645.1  D-aspartate oxidase isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end and has an alternate last exon compared to variant 1. The resulting isoform (2) contains an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC139760
    Consensus CDS
    CCDS87992.1
    UniProtKB/Swiss-Prot
    Q922Z0
    UniProtKB/TrEMBL
    A0A1L1SS55, Q2UVA9
    Related
    ENSMUSP00000149767.2, ENSMUST00000214102.2
    Conserved Domains (1) summary
    pfam01266
    Location:6 → 166
    DAO; FAD dependent oxidoreductase

  2. NM_001316717.2 → NP_001303646.1  D-aspartate oxidase isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate last exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC139760
    Consensus CDS
    CCDS87995.1
    UniProtKB/Swiss-Prot
    Q922Z0
    UniProtKB/TrEMBL
    Q2UVA9
    Related
    ENSMUSP00000150979.2, ENSMUST00000216830.2
    Conserved Domains (1) summary
    pfam01266
    Location:6 → 157
    DAO; FAD dependent oxidoreductase

  3. NM_001316718.2 → NP_001303647.1  D-aspartate oxidase isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate last exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC139760
    Consensus CDS
    CCDS87994.1
    UniProtKB/Swiss-Prot
    Q922Z0
    UniProtKB/TrEMBL
    Q2UVA9, Q9D2B4
    Related
    ENSMUSP00000151066.2, ENSMUST00000213503.2
    Conserved Domains (1) summary
    pfam01266
    Location:6 → 128
    DAO; FAD dependent oxidoreductase

  4. NM_001316719.2 → NP_001303648.1  D-aspartate oxidase isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate last exon compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC139760
    Consensus CDS
    CCDS87993.1
    UniProtKB/Swiss-Prot
    Q922Z0
    UniProtKB/TrEMBL
    A0A1L1SS65, Q9CYP3
    Related
    ENSMUSP00000149768.2, ENSMUST00000213442.2
    Conserved Domains (1) summary
    pfam01266
    Location:6 → 128
    DAO; FAD dependent oxidoreductase

  5. NM_027442.6 → NP_081718.2  D-aspartate oxidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_081718.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC139760
    Consensus CDS
    CCDS23798.1
    UniProtKB/Swiss-Prot
    Q8R2R2, Q922Z0
    Related
    ENSMUSP00000019977.8, ENSMUST00000019977.8
    Conserved Domains (1) summary
    pfam01266
    Location:6 → 324
    DAO; FAD dependent oxidoreductase

RNA

  1. NR_133568.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon and contains two 3' exons in place of the last exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139760
    Related
    ENSMUST00000213856.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    40505933..40557847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156002.1 → XP_036011895.1  D-aspartate oxidase isoform X1

    Conserved Domains (1) summary
    pfam01266
    Location:27 → 206
    DAO; FAD dependent oxidoreductase

  2. XM_036156003.1 → XP_036011896.1  D-aspartate oxidase isoform X2

    Conserved Domains (1) summary
    pfam01266
    Location:6 → 129
    DAO; FAD dependent oxidoreductase

  3. XM_036156004.1 → XP_036011897.1  D-aspartate oxidase isoform X3

    Conserved Domains (1) summary
    pfam01266
    Location:6 → 129
    DAO; FAD dependent oxidoreductase

  4. XM_036156005.1 → XP_036011898.1  D-aspartate oxidase isoform X4

    Conserved Domains (1) summary
    pfam01266
    Location:6 → 129
    DAO; FAD dependent oxidoreductase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922Z0.1 GenPept UniProtKB/Swiss-Prot:Q922Z0

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