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Ddo D-aspartate oxidase [ Mus musculus (house mouse) ]

Gene ID: 70503, updated on 24-Apr-2022

Summary

Official Symbol
Ddoprovided by MGI
Official Full Name
D-aspartate oxidaseprovided by MGI
Primary source
MGI:MGI:1925528
See related
Ensembl:ENSMUSG00000063428 AllianceGenome:MGI:1925528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI467244; 5330420D20Rik; 5730402C02Rik
Summary
Enables D-aspartate oxidase activity and FAD binding activity. Involved in D-amino acid catabolic process. Acts upstream of or within several processes, including aspartate metabolic process; grooming behavior; and insemination. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; chordamesoderm; nervous system; respiratory system; and sensory organ. Orthologous to human DDO (D-aspartate oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 4.3), heart adult (RPKM 4.1) and 12 other tissues See more
Orthologs
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Genomic context

See Ddo in Genome Data Viewer
Location:
10; 10 B1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40505933..40557847)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40630011..40681847)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (40349817..40369737)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17795 Neighboring gene solute carrier family 22 (organic cation transporter), member 16 Neighboring gene methyltransferase like 24 Neighboring gene cell division cycle 40

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-amino-acid oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables D-aspartate oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables D-aspartate oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables D-aspartate oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables FAD binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in D-amino acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in D-amino acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in D-amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in D-amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in aspartate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aspartate catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aspartate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within insemination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D-aspartate oxidase
Names
DASOX
NP_001303645.1
NP_001303646.1
NP_001303647.1
NP_001303648.1
NP_081718.2
XP_036011895.1
XP_036011896.1
XP_036011897.1
XP_036011898.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316716.1NP_001303645.1  D-aspartate oxidase isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end and has an alternate last exon compared to variant 1. The resulting isoform (2) contains an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC139760, AK033375, AM180091
    Consensus CDS
    CCDS87992.1
    UniProtKB/Swiss-Prot
    Q922Z0
    UniProtKB/TrEMBL
    A0A1L1SS55, Q2UVA9
    Related
    ENSMUSP00000149767.2, ENSMUST00000214102.2
    Conserved Domains (1) summary
    pfam01266
    Location:6166
    DAO; FAD dependent oxidoreductase
  2. NM_001316717.1NP_001303646.1  D-aspartate oxidase isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate last exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK033375, AM180091
    Consensus CDS
    CCDS87995.1
    UniProtKB/Swiss-Prot
    Q922Z0
    UniProtKB/TrEMBL
    Q2UVA9
    Related
    ENSMUSP00000150979.2, ENSMUST00000216830.2
    Conserved Domains (1) summary
    pfam01266
    Location:6157
    DAO; FAD dependent oxidoreductase
  3. NM_001316718.1NP_001303647.1  D-aspartate oxidase isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate last exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC139760, AK019898, AK033375, AM180091
    Consensus CDS
    CCDS87994.1
    UniProtKB/Swiss-Prot
    Q922Z0
    UniProtKB/TrEMBL
    Q2UVA9, Q9D2B4
    Related
    ENSMUSP00000151066.2, ENSMUST00000213503.2
    Conserved Domains (1) summary
    pfam01266
    Location:6128
    DAO; FAD dependent oxidoreductase
  4. NM_001316719.1NP_001303648.1  D-aspartate oxidase isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate last exon compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC139760, AK017475, AK033375
    Consensus CDS
    CCDS87993.1
    UniProtKB/Swiss-Prot
    Q922Z0
    UniProtKB/TrEMBL
    A0A1L1SS65, Q9CYP3
    Related
    ENSMUSP00000149768.2, ENSMUST00000213442.2
    Conserved Domains (1) summary
    pfam01266
    Location:6128
    DAO; FAD dependent oxidoreductase
  5. NM_027442.5NP_081718.2  D-aspartate oxidase isoform 1 precursor

    See identical proteins and their annotated locations for NP_081718.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI414897, AK030394, AK033375
    Consensus CDS
    CCDS23798.1
    UniProtKB/Swiss-Prot
    Q922Z0
    Related
    ENSMUSP00000019977.8, ENSMUST00000019977.8
    Conserved Domains (1) summary
    pfam01266
    Location:6324
    DAO; FAD dependent oxidoreductase

RNA

  1. NR_133568.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon and contains two 3' exons in place of the last exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139760, AK033375, AK165344
    Related
    ENSMUST00000213856.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    40505933..40557847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156002.1XP_036011895.1  D-aspartate oxidase isoform X1

    Conserved Domains (1) summary
    pfam01266
    Location:27206
    DAO; FAD dependent oxidoreductase
  2. XM_036156003.1XP_036011896.1  D-aspartate oxidase isoform X2

    Conserved Domains (1) summary
    pfam01266
    Location:6129
    DAO; FAD dependent oxidoreductase
  3. XM_036156004.1XP_036011897.1  D-aspartate oxidase isoform X3

    Conserved Domains (1) summary
    pfam01266
    Location:6129
    DAO; FAD dependent oxidoreductase
  4. XM_036156005.1XP_036011898.1  D-aspartate oxidase isoform X4

    Conserved Domains (1) summary
    pfam01266
    Location:6129
    DAO; FAD dependent oxidoreductase