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LRP11 LDL receptor related protein 11 [ Homo sapiens (human) ]

Gene ID: 84918, updated on 25-Jan-2022

Summary

Official Symbol
LRP11provided by HGNC
Official Full Name
LDL receptor related protein 11provided by HGNC
Primary source
HGNC:HGNC:16936
See related
Ensembl:ENSG00000120256 AllianceGenome:HGNC:16936
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MANSC3; bA350J20.3
Summary
Enables phosphoprotein binding activity. Predicted to act upstream of or within several processes, including response to cold; response to immobilization stress; and response to water deprivation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in prostate (RPKM 11.0), brain (RPKM 10.7) and 24 other tissues See more
Orthologs
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Genomic context

See LRP11 in Genome Data Viewer
Location:
6q25.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149818757..149864359, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150139893..150185495, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene uncharacterized LOC107986660 Neighboring gene BTB domain containing 10 pseudogene 2 Neighboring gene RAET1E antisense RNA 1 Neighboring gene retinoic acid early transcript 1E Neighboring gene chaperonin containing TCP1 subunit 7 pseudogene 1 Neighboring gene multimerin 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of low density lipoprotein receptor-related protein 11 (LRP11) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14735, MGC39092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphoprotein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in multicellular organismal response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to water deprivation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
low-density lipoprotein receptor-related protein 11
Names
LRP-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032832.6NP_116221.3  low-density lipoprotein receptor-related protein 11 precursor

    See identical proteins and their annotated locations for NP_116221.3

    Status: VALIDATED

    Source sequence(s)
    AK027641, AK299599, AL355312, BC025239, BC043141, N91459
    Consensus CDS
    CCDS5220.1
    UniProtKB/Swiss-Prot
    Q86VZ4
    UniProtKB/TrEMBL
    B4DS68
    Related
    ENSP00000239367.2, ENST00000239367.7
    Conserved Domains (3) summary
    smart00765
    Location:84184
    MANEC; The MANEC domain, formerly called MANSC
    cd00112
    Location:310344
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00146
    Location:208296
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    149818757..149864359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536194.3XP_011534496.1  low-density lipoprotein receptor-related protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011534496.1

    Conserved Domains (3) summary
    smart00765
    Location:84184
    MANEC; The MANEC domain, formerly called MANSC
    cd00112
    Location:310344
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00146
    Location:208296
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...
  2. XM_017011380.2XP_016866869.1  low-density lipoprotein receptor-related protein 11 isoform X2

    UniProtKB/TrEMBL
    Q5VYB9
    Related
    ENSP00000356338.2, ENST00000367368.3

RNA

  1. XR_001743696.2 RNA Sequence

  2. XR_942605.3 RNA Sequence

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