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RAET1E retinoic acid early transcript 1E [ Homo sapiens (human) ]

Gene ID: 135250, updated on 23-Nov-2021

Summary

Official Symbol
RAET1Eprovided by HGNC
Official Full Name
retinoic acid early transcript 1Eprovided by HGNC
Primary source
HGNC:HGNC:16793
See related
Ensembl:ENSG00000164520 Ensembl:ENSG00000285991 MIM:609243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7
Summary
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Expression
Biased expression in esophagus (RPKM 7.0) and skin (RPKM 2.7) See more
Orthologs
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Genomic context

See RAET1E in Genome Data Viewer
Location:
6q25.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149864399..149898353, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150204511..150217266, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene uncharacterized LOC107986660 Neighboring gene LDL receptor related protein 11 Neighboring gene RAET1E antisense RNA 1 Neighboring gene chaperonin containing TCP1 subunit 7 pseudogene 1 Neighboring gene multimerin 2 pseudogene Neighboring gene retinoic acid early transcript 1F pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125308, MGC125309

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables natural killer cell lectin-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
retinoic acid early transcript 1E
Names
NKG2D ligand 4
RAE-1-like transcript 4
UL16-binding protein 4
lymphocyte effector toxicity activation ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029833.1 RefSeqGene

    Range
    5001..17685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243325.2NP_001230254.1  retinoic acid early transcript 1E isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL355312
    Consensus CDS
    CCDS59044.1
    UniProtKB/Swiss-Prot
    Q8TD07
    Related
    ENSP00000356332.3, ENST00000367363.3
    Conserved Domains (1) summary
    cl08246
    Location:26159
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. NM_001243327.2NP_001230256.1  retinoic acid early transcript 1E isoform 3 precursor

    See identical proteins and their annotated locations for NP_001230256.1

    Status: REVIEWED

    Source sequence(s)
    AL355312
    Consensus CDS
    CCDS59042.1
    UniProtKB/Swiss-Prot
    Q8TD07
    Related
    ENSP00000432366.1, ENST00000529948.1
    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  3. NM_001243328.3NP_001230257.1  retinoic acid early transcript 1E isoform 4 precursor

    See identical proteins and their annotated locations for NP_001230257.1

    Status: REVIEWED

    Source sequence(s)
    AL355312
    Consensus CDS
    CCDS59043.1
    UniProtKB/Swiss-Prot
    Q8TD07
    Related
    ENSP00000437067.1, ENST00000532335.5
    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  4. NM_001394056.1NP_001380985.1  retinoic acid early transcript 1E isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AL355312
    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  5. NM_001394057.1NP_001380986.1  retinoic acid early transcript 1E isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL355312
    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  6. NM_139165.3NP_631904.1  retinoic acid early transcript 1E isoform 1 precursor

    See identical proteins and their annotated locations for NP_631904.1

    Status: REVIEWED

    Source sequence(s)
    AL355312
    Consensus CDS
    CCDS5221.1
    UniProtKB/Swiss-Prot
    Q8TD07
    Related
    ENSP00000349709.4, ENST00000357183.8
    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    149864399..149898353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010286.1XP_016865775.1  retinoic acid early transcript 1E isoform X2

    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. XM_017010287.1XP_016865776.1  retinoic acid early transcript 1E isoform X2

    Related
    ENSP00000498179.1, ENST00000647612.1
    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  3. XM_017010285.1XP_016865774.1  retinoic acid early transcript 1E isoform X2

    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  4. XM_011535475.2XP_011533777.1  retinoic acid early transcript 1E isoform X1

    See identical proteins and their annotated locations for XP_011533777.1

    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  5. XM_011535476.2XP_011533778.1  retinoic acid early transcript 1E isoform X1

    See identical proteins and their annotated locations for XP_011533778.1

    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  6. XM_011535479.2XP_011533781.1  retinoic acid early transcript 1E isoform X4

    See identical proteins and their annotated locations for XP_011533781.1

    UniProtKB/Swiss-Prot
    Q8TD07
    Conserved Domains (1) summary
    cl08246
    Location:30195
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  7. XM_017010288.1XP_016865777.1  retinoic acid early transcript 1E isoform X5

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