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ARHGEF39 Rho guanine nucleotide exchange factor 39 [ Homo sapiens (human) ]

Gene ID: 84904, updated on 8-Dec-2022

Summary

Official Symbol
ARHGEF39provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 39provided by HGNC
Primary source
HGNC:HGNC:25909
See related
Ensembl:ENSG00000137135 AllianceGenome:HGNC:25909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf100
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 7.7), adrenal (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

See ARHGEF39 in Genome Data Viewer
Location:
9p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (35659343..35665195, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (35679995..35685847, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35659340..35665192, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene signaling threshold regulating transmembrane adaptor 1 Neighboring gene coiled-coil domain containing 107 Neighboring gene RNA component of mitochondrial RNA processing endoribonuclease Neighboring gene Sharpr-MPRA regulatory region 3743 Neighboring gene RNA, 7SL, cytoplasmic 22, pseudogene Neighboring gene carbonic anhydrase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14642, MGC44886

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 39
Names
Rho guanine nucleotide exchange factor (GEF) 39
vav-like protein C9orf100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032818.3NP_116207.2  rho guanine nucleotide exchange factor 39

    See identical proteins and their annotated locations for NP_116207.2

    Status: VALIDATED

    Source sequence(s)
    AL357874, BC033666, DB109516
    Consensus CDS
    CCDS6584.2
    UniProtKB/Swiss-Prot
    Q8N4T4, Q96ST6
    Related
    ENSP00000367638.3, ENST00000378387.4
    Conserved Domains (2) summary
    smart00233
    Location:228331
    PH; Pleckstrin homology domain
    cl02571
    Location:27195
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    35659343..35665195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    35679995..35685847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)