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ARHGEF39 Rho guanine nucleotide exchange factor 39 [ Homo sapiens (human) ]

Gene ID: 84904, updated on 18-Aug-2020

Summary

Official Symbol
ARHGEF39provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 39provided by HGNC
Primary source
HGNC:HGNC:25909
See related
Ensembl:ENSG00000137135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf100
Expression
Ubiquitous expression in fat (RPKM 7.7), adrenal (RPKM 3.6) and 25 other tissues See more
Orthologs

Genomic context

See ARHGEF39 in Genome Data Viewer
Location:
9p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35658875..35665205, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35658872..35675863, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene signaling threshold regulating transmembrane adaptor 1 Neighboring gene coiled-coil domain containing 107 Neighboring gene RNA component of mitochondrial RNA processing endoribonuclease Neighboring gene RNA, 7SL, cytoplasmic 22, pseudogene Neighboring gene carbonic anhydrase 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14642, MGC44886

Gene Ontology Provided by GOA

Function Evidence Code Pubs
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 39
Names
Rho guanine nucleotide exchange factor (GEF) 39
vav-like protein C9orf100

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032818.3NP_116207.2  rho guanine nucleotide exchange factor 39

    See identical proteins and their annotated locations for NP_116207.2

    Status: VALIDATED

    Source sequence(s)
    AL357874, BC033666, DB109516
    Consensus CDS
    CCDS6584.2
    UniProtKB/Swiss-Prot
    Q8N4T4
    Related
    ENSP00000367638.3, ENST00000378387.4
    Conserved Domains (2) summary
    smart00233
    Location:228331
    PH; Pleckstrin homology domain
    cl02571
    Location:27195
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35658875..35665205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015225.1XP_016870714.1  rho guanine nucleotide exchange factor 39 isoform X2

  2. XM_011518057.2XP_011516359.1  rho guanine nucleotide exchange factor 39 isoform X1

    Conserved Domains (2) summary
    cl02571
    Location:27195
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cl17171
    Location:225269
    PH-like; Pleckstrin homology-like domain
  3. XM_017015227.1XP_016870716.1  rho guanine nucleotide exchange factor 39 isoform X4

  4. XM_017015226.1XP_016870715.1  rho guanine nucleotide exchange factor 39 isoform X3

    Related
    ENST00000490970.5
  5. XM_017015228.1XP_016870717.1  rho guanine nucleotide exchange factor 39 isoform X5

RNA

  1. XR_929354.2 RNA Sequence

  2. XR_929352.2 RNA Sequence

  3. XR_001746399.2 RNA Sequence

  4. XR_929366.3 RNA Sequence

  5. XR_001746401.1 RNA Sequence

    Related
    ENST00000475323.5
  6. XR_001746400.1 RNA Sequence

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