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Arhgef39 Rho guanine nucleotide exchange factor (GEF) 39 [ Mus musculus (house mouse) ]

Gene ID: 230098, updated on 26-Sep-2022

Summary

Official Symbol
Arhgef39provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 39provided by MGI
Primary source
MGI:MGI:3036286
See related
Ensembl:ENSMUSG00000051517 AllianceGenome:MGI:3036286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130306D19Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of cell migration. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ARHGEF39 (Rho guanine nucleotide exchange factor 39). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 17.9), colon adult (RPKM 15.8) and 21 other tissues See more
Orthologs
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Genomic context

See Arhgef39 in Genome Data Viewer
Location:
4; 4 A5
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43496139..43508747, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43496139..43508747, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 107 Neighboring gene RNA component of mitochondrial RNAase P Neighboring gene carbonic anhydrase 9 Neighboring gene tropomyosin 2, beta Neighboring gene talin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 39
Names
vav-like protein C9orf100 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013377.3NP_001013395.2  rho guanine nucleotide exchange factor 39

    See identical proteins and their annotated locations for NP_001013395.2

    Status: VALIDATED

    Source sequence(s)
    AL732506, BC080700, BY110275, BY210170, CA326178
    Consensus CDS
    CCDS18098.1
    UniProtKB/Swiss-Prot
    Q3TQV6, Q66JY6
    UniProtKB/TrEMBL
    A0A8C6HHM1
    Related
    ENSMUSP00000055293.7, ENSMUST00000054538.13
    Conserved Domains (4) summary
    smart00233
    Location:228331
    PH; Pleckstrin homology domain
    pfam00169
    Location:230331
    PH; PH domain
    pfam00621
    Location:27196
    RhoGEF; RhoGEF domain
    cl17171
    Location:199255
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43496139..43508747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253417.1XP_030109277.1  rho guanine nucleotide exchange factor 39 isoform X1

    Conserved Domains (3) summary
    smart00233
    Location:228331
    PH; Pleckstrin homology domain
    pfam00621
    Location:27195
    RhoGEF; RhoGEF domain
    cl17171
    Location:199255
    PH-like; Pleckstrin homology-like domain