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CAT catalase [ Homo sapiens (human) ]

Gene ID: 847, updated on 13-May-2022

Summary

Official Symbol
CATprovided by HGNC
Official Full Name
catalaseprovided by HGNC
Primary source
HGNC:HGNC:1516
See related
Ensembl:ENSG00000121691 MIM:115500; AllianceGenome:HGNC:1516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Expression
Broad expression in liver (RPKM 283.8), fat (RPKM 207.7) and 23 other tissues See more
Orthologs
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Genomic context

See CAT in Genome Data Viewer
Location:
11p13
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (34438934..34472060)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (34575773..34608901)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34460481..34493607)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376622 Neighboring gene CIR1 pseudogene 3 Neighboring gene E74 like ETS transcription factor 5 Neighboring gene long intergenic non-protein coding RNA 2707

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Free radical scavengers such as superoxide dismutase (SOD), dimethylthiourea (DMTU) and catalase attenuate morphine and gp160-induced human monocyte apoptosis PubMed
Tat tat HIV-1 Tat upregulates NQO1, CAT, SOD1, SOD2, and HMOX1 (HO1) mRNA levels in SH-SY5Y cells PubMed
tat Exposure to HIV-1 clade B Tat protein has a greater inhibition of GSS, GPx1, SOD1, and CAT expression compared with exposure to clade C Tat protein in monocyte-derived immature dendritic cells PubMed
tat HIV-1 Tat increases catalase and glutathione peroxidase 1 (GPX1) activities in human cardiac myocyte PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138422, MGC138424

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables aminoacylase activity IEA
Inferred from Electronic Annotation
more info
 
enables antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables catalase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables catalase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on peroxide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 
enables peroxisome targeting sequence binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in UV protection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aerobic respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular detoxification of hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hemoglobin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoblast differentiation HDA PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in response to L-ascorbic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to inactivity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lead ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to light intensity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ozone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to phenylpropanoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to vitamin A IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin E IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
part_of catalase complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in focal adhesion HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 
located_in peroxisomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
catalase
Names
epididymis secretory sperm binding protein
NP_001743.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013339.2 RefSeqGene

    Range
    5010..38136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001752.4NP_001743.1  catalase

    See identical proteins and their annotated locations for NP_001743.1

    Status: REVIEWED

    Source sequence(s)
    AK291585, AL035079, AW023382
    Consensus CDS
    CCDS7891.1
    UniProtKB/Swiss-Prot
    P04040
    Related
    ENSP00000241052.4, ENST00000241052.5
    Conserved Domains (1) summary
    cd08156
    Location:68497
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    34438934..34472060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    34575773..34608901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)