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Cat catalase [ Mus musculus (house mouse) ]

Gene ID: 12359, updated on 8-Feb-2024

Summary

Official Symbol
Catprovided by MGI
Official Full Name
catalaseprovided by MGI
Primary source
MGI:MGI:88271
See related
Ensembl:ENSMUSG00000027187 AllianceGenome:MGI:88271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cas1; Cs-1; Cas-1; 2210418N07
Summary
Enables aminoacylase activity and catalase activity. Acts upstream of or within several processes, including hydrogen peroxide catabolic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of DNA-binding transcription factor activity. Located in peroxisomal membrane. Is expressed in several structures, including alimentary system; early conceptus; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including acatalasia; eye disease (multiple); lung disease (multiple); osteonecrosis; and pseudoxanthoma elasticum. Orthologous to human CAT (catalase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 579.2), kidney adult (RPKM 214.7) and 12 other tissues See more
Orthologs
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Genomic context

See Cat in Genome Data Viewer
Location:
2 E2; 2 54.43 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103284249..103315498, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103453904..103485153, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC016548 Neighboring gene E74-like factor 5 Neighboring gene STARR-seq mESC enhancer starr_05270 Neighboring gene STARR-positive B cell enhancer ABC_E811 Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7843 Neighboring gene STARR-positive B cell enhancer ABC_E812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103408122-103408323 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene VISTA enhancer mm1312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103502331-103502560 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103522571-103522790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103543647-103543756 Neighboring gene STARR-positive B cell enhancer ABC_E11149 Neighboring gene STARR-positive B cell enhancer ABC_E4483 Neighboring gene N-acetyltransferase 10 Neighboring gene cell cycle associated protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables aminoacylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
enables catalase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables catalase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables catalase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables catalase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on peroxide as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in UV protection ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular detoxification of hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular oxidant detoxification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemoglobin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
catalase
Names
catalase 1
NP_033934.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009804.2NP_033934.2  catalase

    See identical proteins and their annotated locations for NP_033934.2

    Status: VALIDATED

    Source sequence(s)
    AK150893, AL773505, BY093963
    Consensus CDS
    CCDS16478.1
    UniProtKB/Swiss-Prot
    P24270, Q3TXQ6
    UniProtKB/TrEMBL
    Q3UF58, Q3UZE7, Q542K4, Q8C6E3
    Related
    ENSMUSP00000028610.4, ENSMUST00000028610.10
    Conserved Domains (2) summary
    cd08156
    Location:68497
    catalase_clade_3; Clade 3 of the heme-binding enzyme catalase
    COG0753
    Location:17500
    KatE; Catalase [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103284249..103315498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)