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SLC9A7 solute carrier family 9 member A7 [ Homo sapiens (human) ]

Gene ID: 84679, updated on 17-Jun-2024

Summary

Official Symbol
SLC9A7provided by HGNC
Official Full Name
solute carrier family 9 member A7provided by HGNC
Primary source
HGNC:HGNC:17123
See related
Ensembl:ENSG00000065923 MIM:300368; AllianceGenome:HGNC:17123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NHE7; NHE-7; MRX108; SLC9A6
Summary
This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Expression
Broad expression in brain (RPKM 6.0), lymph node (RPKM 3.6) and 24 other tissues See more
Orthologs
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Genomic context

See SLC9A7 in Genome Data Viewer
Location:
Xp11.3; Xp11.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (46599251..46759118, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (46006221..46166134, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (46458686..46618553, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20791 Neighboring gene marker of proliferation Ki-67 pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:46447043-46447647 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:46447648-46448251 Neighboring gene carbohydrate sulfotransferase 7 Neighboring gene uncharacterized LOC124905182 Neighboring gene phosphoglycerate mutase 1 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29572 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:46569386-46570585 Neighboring gene Y-box binding protein 1 pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29574 Neighboring gene CHMP5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29576 Neighboring gene Sharpr-MPRA regulatory region 10799 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:46673232-46673357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29577 Neighboring gene RP2 activator of ARL3 GTPase Neighboring gene long intergenic non-protein coding RNA 1545

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef EIPA, a potent and specific inhibitor of Na+/H+ exchanger activity, significantly inhibits the Nef internalization into M2-macrophages, indicating that Nef is imported by Na+/H+ exchanger (solute carrier family 9, subfamily A) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39602

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:proton antiporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in monoatomic ion transport TAS
Traceable Author Statement
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Golgi lumen acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sodium/hydrogen exchanger 7
Names
Na(+)/H(+) exchanger 7
nonselective sodium potassium/proton exchanger
solute carrier family 9 (sodium/hydrogen exchanger)
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012622.2 RefSeqGene

    Range
    4920..164787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257291.2NP_001244220.1  sodium/hydrogen exchanger 7 isoform 1

    See identical proteins and their annotated locations for NP_001244220.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI081096, AL022165, BC094742
    Consensus CDS
    CCDS75967.1
    UniProtKB/TrEMBL
    A0A087WXD1
    Related
    ENSP00000480916.1, ENST00000616978.5
    Conserved Domains (1) summary
    pfam00999
    Location:176535
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  2. NM_032591.3NP_115980.1  sodium/hydrogen exchanger 7 isoform 2

    See identical proteins and their annotated locations for NP_115980.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF298591, AI081096, AL022165, AL050307
    Consensus CDS
    CCDS14269.1
    UniProtKB/Swiss-Prot
    O75827, Q5JXP9, Q96T83
    Related
    ENSP00000330320.4, ENST00000328306.4
    Conserved Domains (1) summary
    pfam00999
    Location:176534
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    46599251..46759118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029905.2XP_016885394.1  sodium/hydrogen exchanger 7 isoform X1

    UniProtKB/TrEMBL
    A0A087WXD1
    Conserved Domains (1) summary
    pfam00999
    Location:176535
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  2. XM_005272682.5XP_005272739.1  sodium/hydrogen exchanger 7 isoform X1

    See identical proteins and their annotated locations for XP_005272739.1

    UniProtKB/TrEMBL
    A0A087WXD1
    Conserved Domains (1) summary
    pfam00999
    Location:176535
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  3. XM_011543990.3XP_011542292.1  sodium/hydrogen exchanger 7 isoform X1

    See identical proteins and their annotated locations for XP_011542292.1

    UniProtKB/TrEMBL
    A0A087WXD1
    Conserved Domains (1) summary
    pfam00999
    Location:176535
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  4. XM_005272681.5XP_005272738.1  sodium/hydrogen exchanger 7 isoform X1

    See identical proteins and their annotated locations for XP_005272738.1

    UniProtKB/TrEMBL
    A0A087WXD1
    Conserved Domains (1) summary
    pfam00999
    Location:176535
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  5. XM_047442581.1XP_047298537.1  sodium/hydrogen exchanger 7 isoform X2

  6. XM_047442582.1XP_047298538.1  sodium/hydrogen exchanger 7 isoform X2

  7. XM_017029906.3XP_016885395.1  sodium/hydrogen exchanger 7 isoform X2

    Conserved Domains (1) summary
    pfam00999
    Location:176535
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RNA

  1. XR_007068203.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    46006221..46166134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327996.1XP_054183971.1  sodium/hydrogen exchanger 7 isoform X1

    UniProtKB/TrEMBL
    A0A087WXD1
  2. XM_054327994.1XP_054183969.1  sodium/hydrogen exchanger 7 isoform X1

    UniProtKB/TrEMBL
    A0A087WXD1
  3. XM_054327995.1XP_054183970.1  sodium/hydrogen exchanger 7 isoform X1

    UniProtKB/TrEMBL
    A0A087WXD1
  4. XM_054327993.1XP_054183968.1  sodium/hydrogen exchanger 7 isoform X1

    UniProtKB/TrEMBL
    A0A087WXD1
  5. XM_054327998.1XP_054183973.1  sodium/hydrogen exchanger 7 isoform X2

  6. XM_054327999.1XP_054183974.1  sodium/hydrogen exchanger 7 isoform X2

  7. XM_054327997.1XP_054183972.1  sodium/hydrogen exchanger 7 isoform X2

RNA

  1. XR_008485512.1 RNA Sequence