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TTF2 transcription termination factor 2 [ Homo sapiens (human) ]

Gene ID: 8458, updated on 5-Sep-2021

Summary

Official Symbol
TTF2provided by HGNC
Official Full Name
transcription termination factor 2provided by HGNC
Primary source
HGNC:HGNC:12398
See related
Ensembl:ENSG00000116830 MIM:604718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F2; HuF2; ZGRF6
Summary
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
Annotation information
Note: TTF2 (Gene ID: 8458) and FOXE1 (Gene ID: 2304) share the TTF2 symbol/alias in common. TTF2 is a widely used alternative name for forkhead box E1 (FOXE1), which can be confused with the official symbol for transcription termination factor 2 (TTF2). [31 May 2018]
Expression
Ubiquitous expression in lymph node (RPKM 3.1), appendix (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

See TTF2 in Genome Data Viewer
Location:
1p13.1
Exon count:
25
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (117060303..117107453)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (117602948..117650075)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prostaglandin F2 receptor inhibitor Neighboring gene Sharpr-MPRA regulatory region 2959 Neighboring gene CD101 molecule Neighboring gene CD101 antisense RNA 1 Neighboring gene microRNA 942 Neighboring gene tripartite motif containing 45 Neighboring gene ribosomal protein S15a pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Depletion of transcription termination factor, RNA polymerase II (TTF2) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription, termination TAS
Traceable Author Statement
more info
PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription elongation factor complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
transcription termination factor 2
Names
RNA polymerase II termination factor
human factor 2
lodestar homolog
lodestar protein
transcription release factor 2
transcription termination factor, RNA polymerase II
zinc finger, GRF-type containing 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003594.4NP_003585.3  transcription termination factor 2

    See identical proteins and their annotated locations for NP_003585.3

    Status: REVIEWED

    Source sequence(s)
    AF073771, AF080255, AI991355, AL391476, AL445231, AW027795, BC030058, BI857056, BQ422564, BU182600, H81916
    Consensus CDS
    CCDS892.1
    UniProtKB/Swiss-Prot
    Q9UNY4
    UniProtKB/TrEMBL
    A0A024R0F1
    Related
    ENSP00000358478.3, ENST00000369466.9
    Conserved Domains (4) summary
    cd00046
    Location:590768
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:573933
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:9901106
    Helicase_C; Helicase conserved C-terminal domain
    pfam06839
    Location:439
    zf-GRF; GRF zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    117060303..117107453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542303.3XP_011540605.1  transcription termination factor 2 isoform X5

    See identical proteins and their annotated locations for XP_011540605.1

    Conserved Domains (4) summary
    cd00046
    Location:597775
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:580940
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:9971113
    Helicase_C; Helicase conserved C-terminal domain
    pfam06839
    Location:439
    zf-GRF; GRF zinc finger
  2. XM_017002552.2XP_016858041.1  transcription termination factor 2 isoform X2

  3. XM_017002553.2XP_016858042.1  transcription termination factor 2 isoform X3

  4. XM_017002554.2XP_016858043.1  transcription termination factor 2 isoform X4

  5. XM_005271277.4XP_005271334.1  transcription termination factor 2 isoform X7

    Conserved Domains (4) summary
    cd00046
    Location:593767
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:573932
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:9891105
    Helicase_C; Helicase conserved C-terminal domain
    pfam06839
    Location:439
    zf-GRF; GRF zinc finger
  6. XM_017002550.2XP_016858039.1  transcription termination factor 2 isoform X1

  7. XM_017002551.2XP_016858040.1  transcription termination factor 2 isoform X1

  8. XM_017002555.2XP_016858044.1  transcription termination factor 2 isoform X6

    UniProtKB/Swiss-Prot
    Q9UNY4
    UniProtKB/TrEMBL
    A0A024R0F1
    Conserved Domains (4) summary
    cd00046
    Location:590768
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:573933
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:9901106
    Helicase_C; Helicase conserved C-terminal domain
    pfam06839
    Location:439
    zf-GRF; GRF zinc finger

RNA

  1. XR_002957810.1 RNA Sequence

  2. XR_001737489.2 RNA Sequence

  3. XR_001737490.2 RNA Sequence

  4. XR_002957812.1 RNA Sequence

  5. XR_002957811.1 RNA Sequence

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