Send to:

Choose Destination

DUSP11 dual specificity phosphatase 11 [ Homo sapiens (human) ]

Gene ID: 8446, updated on 23-Nov-2021


Official Symbol
DUSP11provided by HGNC
Official Full Name
dual specificity phosphatase 11provided by HGNC
Primary source
See related
Ensembl:ENSG00000144048 MIM:603092
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Ubiquitous expression in esophagus (RPKM 14.8), urinary bladder (RPKM 12.3) and 25 other tissues See more
Try the new Gene table
Try the new Transcript table

Genomic context

See DUSP11 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (73762213..73780103, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73989325..74007284, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 15607 Neighboring gene TP53RK binding protein Neighboring gene chromosome 2 open reading frame 78 Neighboring gene uncharacterized LOC105374807 Neighboring gene STAM binding protein

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
GeneReviews: Not available
Genetic loci influencing kidney function and chronic kidney disease.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dual specificity phosphatase 11 (RNA/RNP complex 1-interacting, DUSP11) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Potential readthrough

Included gene: TPRKB


Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in RNA metabolic process IDA
Inferred from Direct Assay
more info
involved_in RNA processing TAS
Traceable Author Statement
more info
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
involved_in polynucleotide 5' dephosphorylation IDA
Inferred from Direct Assay
more info
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
Component Evidence Code Pubs
located_in fibrillar center IDA
Inferred from Direct Assay
more info
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
located_in nuclear speck IDA
Inferred from Direct Assay
more info
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
located_in nucleus TAS
Traceable Author Statement
more info

General protein information

Preferred Names
RNA/RNP complex-1-interacting phosphatase
RNA/RNP complex 1-interacting
RNA/RNP complex-interacting phosphatase
dual specificity protein phosphatase 11
phosphatase that interacts with RNA/RNP complex 1
serine/threonine specific protein phosphatase

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003584.3NP_003575.3  RNA/RNP complex-1-interacting phosphatase

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    ENSP00000272444.3, ENST00000272444.7
    Conserved Domains (1) summary
    DSP_DUSP11; dual-specificity phosphatase domain of dual specificity protein phosphatase 11 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    73762213..73780103 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center