Format

Send to:

Choose Destination

DUSP11 dual specificity phosphatase 11 [ Homo sapiens (human) ]

Gene ID: 8446, updated on 21-Dec-2019

Summary

Official Symbol
DUSP11provided by HGNC
Official Full Name
dual specificity phosphatase 11provided by HGNC
Primary source
HGNC:HGNC:3066
See related
Ensembl:ENSG00000144048 MIM:603092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIR1
Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in esophagus (RPKM 14.8), urinary bladder (RPKM 12.3) and 25 other tissues See more
Orthologs

Genomic context

See DUSP11 in Genome Data Viewer
Location:
2p13.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (73762198..73780157, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73989325..74007284, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase 8B (putative, gene/pseudogene) Neighboring gene TP53RK binding protein Neighboring gene chromosome 2 open reading frame 78 Neighboring gene uncharacterized LOC105374807 Neighboring gene STAM binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
NHGRI GWA Catalog
Genetic loci influencing kidney function and chronic kidney disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dual specificity phosphatase 11 (RNA/RNP complex 1-interacting, DUSP11) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TPRKB

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide phosphatase activity, acting on free nucleotides IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
polynucleotide 5'-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polynucleotide 5'-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
RNA processing TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
polynucleotide 5' dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
fibrillar center IDA
Inferred from Direct Assay
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA/RNP complex-1-interacting phosphatase
Names
RNA/RNP complex 1-interacting
RNA/RNP complex-interacting phosphatase
dual specificity protein phosphatase 11
phosphatase that interacts with RNA/RNP complex 1
serine/threonine specific protein phosphatase
NP_003575.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003584.2NP_003575.2  RNA/RNP complex-1-interacting phosphatase

    See identical proteins and their annotated locations for NP_003575.2

    Status: REVIEWED

    Source sequence(s)
    AF023917, BC000346, BP349009, BP359552
    Consensus CDS
    CCDS1928.2
    UniProtKB/Swiss-Prot
    O75319
    Related
    ENSP00000272444.3, ENST00000272444.7
    Conserved Domains (1) summary
    cl21483
    Location:130243
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    73762198..73780157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center