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Nat Genet. 2010 May;42(5):373-5. doi: 10.1038/ng.566. Epub 2010 Apr 11.

Genetic loci influencing kidney function and chronic kidney disease.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK. john.chambers@ic.ac.uk

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

PMID:
20383145
PMCID:
PMC3748585
DOI:
10.1038/ng.566
[Indexed for MEDLINE]
Free PMC Article

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