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Dusp11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) [ Mus musculus (house mouse) ]

Gene ID: 72102, updated on 18-Sep-2024

Summary

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Official Symbol
Dusp11provided by MGI
Official Full Name
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)provided by MGI
Primary source
MGI:MGI:1919352
See related
Ensembl:ENSMUSG00000030002 AllianceGenome:MGI:1919352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010300F21Rik
Summary
Predicted to enable RNA binding activity and phosphatase activity. Predicted to be involved in RNA metabolic process; polynucleotide 5' dephosphorylation; and protein dephosphorylation. Predicted to be located in fibrillar center; intercellular bridge; and nuclear speck. Is expressed in central nervous system and retina. Orthologous to human DUSP11 (dual specificity phosphatase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 27.2), whole brain E14.5 (RPKM 25.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dusp11 in Genome Data Viewer
Location:
6 C3; 6 37.54 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85919250..85938950, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85942268..85961732, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:85887170-85887279 Neighboring gene N-acetyltransferase 8B, pseudogene Neighboring gene prohibitin pseudogene Neighboring gene uncharacterized LOC118567396 Neighboring gene STARR-positive B cell enhancer ABC_E6449 Neighboring gene predicted gene, 33319 Neighboring gene STARR-seq mESC enhancer starr_16515 Neighboring gene RIKEN cDNA 4930553P18 gene Neighboring gene folliculogenesis specific basic helix-loop-helix

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DUSP11 Attenuates Lipopolysaccharide-Induced Macrophage Activation by Targeting TAK1. Yang CY, et al. J Immunol, 2020 Sep 15. PMID 32796023, Free PMC Article
  2. DUSP11-mediated control of 5'-triphosphate RNA regulates RIG-I sensitivity. Choi JH, et al. Genes Dev, 2020 Dec 1. PMID 33184222, Free PMC Article
  3. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789
  4. Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss. Celaya AM, et al. Elife, 2019 Apr 2. PMID 30938680, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables polynucleotide 5'-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polynucleotide 5'-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables polynucleotide 5'-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA/RNP complex-1-interacting phosphatase
Names
phosphatase that interacts with RNA/RNP complex 1
NP_082375.4
XP_011239778.1
XP_017177243.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028099.4 → NP_082375.4  RNA/RNP complex-1-interacting phosphatase

    See identical proteins and their annotated locations for NP_082375.4

    Status: VALIDATED

    Source sequence(s)
    AK089506, BB613140, BC055282, BC067028
    Consensus CDS
    CCDS20306.1
    UniProtKB/Swiss-Prot
    Q6NXK5, Q8BTR4, Q8BYE4
    Related
    ENSMUSP00000032071.10, ENSMUST00000032071.13
    Conserved Domains (1) summary
    cl21483
    Location:119 → 195
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85919250..85938950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321754.2 → XP_017177243.1  RNA/RNP complex-1-interacting phosphatase isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:2 → 136
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_011241476.3 → XP_011239778.1  RNA/RNP complex-1-interacting phosphatase isoform X2

    See identical proteins and their annotated locations for XP_011239778.1

    UniProtKB/TrEMBL
    Q9D851
    Conserved Domains (1) summary
    cl28904
    Location:1 → 29
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

  1. XR_001785172.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXK5.1 GenPept UniProtKB/Swiss-Prot:Q6NXK5

Gene LinkOut

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