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GINS4 GINS complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 84296, updated on 21-Dec-2019

Summary

Official Symbol
GINS4provided by HGNC
Official Full Name
GINS complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:28226
See related
Ensembl:ENSG00000147536 MIM:610611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLD5
Summary
The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
Expression
Broad expression in lymph node (RPKM 2.4), appendix (RPKM 2.0) and 23 other tissues See more
Orthologs

Genomic context

See GINS4 in Genome Data Viewer
Location:
8p11.21
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (41529205..41545030)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41386725..41402565)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene golgin A7 Neighboring gene keratin 18 pseudogene 37 Neighboring gene uncharacterized LOC102723729 Neighboring gene glycerol-3-phosphate acyltransferase 4 Neighboring gene NK6 homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of GINS complex subunit 4 (GINS4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14799

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
DNA strand elongation involved in DNA replication TAS
Traceable Author Statement
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner cell mass cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA replication complex GINS protein SLD5
Names
SLD5 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032336.3NP_115712.1  DNA replication complex GINS protein SLD5

    See identical proteins and their annotated locations for NP_115712.1

    Status: VALIDATED

    Source sequence(s)
    AC009630, BC005995
    Consensus CDS
    CCDS6116.1
    UniProtKB/Swiss-Prot
    Q9BRT9
    Related
    ENSP00000276533.3, ENST00000276533.4
    Conserved Domains (3) summary
    cd11711
    Location:26146
    GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
    COG5086
    Location:18223
    COG5086; Uncharacterized conserved protein [Function unknown]
    pfam16922
    Location:165223
    SLD5_C; DNA replication complex GINS protein SLD5 C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    41529205..41545030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273659.4XP_005273716.1  DNA replication complex GINS protein SLD5 isoform X1

    See identical proteins and their annotated locations for XP_005273716.1

    UniProtKB/Swiss-Prot
    Q9BRT9
    Related
    ENSP00000428754.1, ENST00000518671.5
    Conserved Domains (3) summary
    cd11711
    Location:26146
    GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
    COG5086
    Location:18223
    COG5086; Uncharacterized conserved protein [Function unknown]
    pfam16922
    Location:165223
    SLD5_C; DNA replication complex GINS protein SLD5 C-terminus
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