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Gins4 GINS complex subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 109145, updated on 30-Apr-2024

Summary

Official Symbol
Gins4provided by MGI
Official Full Name
GINS complex subunit 4provided by MGI
Primary source
MGI:MGI:1923847
See related
Ensembl:ENSMUSG00000031546 AllianceGenome:MGI:1923847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sld5; 2810037C03Rik; 4933405K01Rik
Summary
Acts upstream of or within inner cell mass cell proliferation. Located in cytoplasm and nucleus. Is expressed in alimentary system; brain; genitourinary system; trachea; and vibrissa. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 22.2), liver E14 (RPKM 21.2) and 26 other tissues See more
Orthologs
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Genomic context

See Gins4 in Genome Data Viewer
Location:
8 A2; 8 11.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23716626..23727684, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (23226610..23237668, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20914 Neighboring gene predicted gene, 30306 Neighboring gene predicted gene, 30247 Neighboring gene glycerol-3-phosphate acyltransferase 4 Neighboring gene STARR-positive B cell enhancer ABC_E10494 Neighboring gene STARR-positive B cell enhancer ABC_E356 Neighboring gene predicted gene, 39141 Neighboring gene golgin A7 Neighboring gene predicted gene, 24335

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of CMG complex ISO
Inferred from Sequence Orthology
more info
 
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of GINS complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
DNA replication complex GINS protein SLD5
Names
GINS complex subunit 4 (Sld5 homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024240.6NP_077202.1  DNA replication complex GINS protein SLD5

    See identical proteins and their annotated locations for NP_077202.1

    Status: VALIDATED

    Source sequence(s)
    AK076104, BB750165, BG342391, BY309805
    Consensus CDS
    CCDS22190.1
    UniProtKB/Swiss-Prot
    Q3TP06, Q99LZ3
    Related
    ENSMUSP00000033950.6, ENSMUST00000033950.7
    Conserved Domains (3) summary
    cd11711
    Location:26146
    GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
    COG5086
    Location:23223
    COG5086; Uncharacterized conserved protein [Function unknown]
    pfam16922
    Location:165223
    SLD5_C; DNA replication complex GINS protein SLD5 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    23716626..23727684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)