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NICN1 nicolin 1 [ Homo sapiens (human) ]

Gene ID: 84276, updated on 5-Aug-2018

Summary

Official Symbol
NICN1provided by HGNC
Official Full Name
nicolin 1provided by HGNC
Primary source
HGNC:HGNC:18317
See related
Ensembl:ENSG00000145029 MIM:611516; Vega:OTTHUMG00000156848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This protein encoded by this gene localizes to the nucleus and is expressed in numerous tissues including brain, testis, liver, and kidney. This refseq contains genomic sequence in its 3' UTR which is not supported by experimental evidence. Computer predictions indicate that this region of the 3' UTR contains hairpin-forming self-complementary sequence which is possibly excised after transcription. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 9.6), thyroid (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See NICN1 in Genome Data Viewer
Location:
3p21.31
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (49422333..49429324, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49459766..49466777, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ras homolog family member A Neighboring gene T cell leukemia translocation altered Neighboring gene aminomethyltransferase Neighboring gene RNA, 5S ribosomal pseudogene 130 Neighboring gene dystroglycan 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12936

Gene Ontology Provided by GOA

Component Evidence Code Pubs
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nicolin-1
Names
NPCEDRG
PGs5
tubulin polyglutamylase complex subunit 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033046.1 RefSeqGene

    Range
    5001..11992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032316.3NP_115692.1  nicolin-1

    See identical proteins and their annotated locations for NP_115692.1

    Status: REVIEWED

    Source sequence(s)
    AC104452, BC050653
    Consensus CDS
    CCDS2798.1
    UniProtKB/Swiss-Prot
    Q9BSH3
    UniProtKB/TrEMBL
    B2R7Q3
    Related
    ENSP00000273598.3, OTTHUMP00000210795, ENST00000273598.7, OTTHUMT00000346224

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    49422333..49429324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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