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ZNF282 zinc finger protein 282 [ Homo sapiens (human) ]

Gene ID: 8427, updated on 5-Jan-2022

Summary

Official Symbol
ZNF282provided by HGNC
Official Full Name
zinc finger protein 282provided by HGNC
Primary source
HGNC:HGNC:13076
See related
Ensembl:ENSG00000170265 MIM:603397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUB1
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in endometrium (RPKM 6.2), prostate (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF282 in Genome Data Viewer
Location:
7q36.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (149195495..149226243)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148892638..148923334)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 398 Neighboring gene uncharacterized LOC107986856 Neighboring gene centrosomal protein 83kDa pseudogene Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene zinc finger protein 212 Neighboring gene zinc finger protein 783

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
zinc finger protein 282
Names
HTLV-I U5 repressive element-binding protein 1
HTLV-I U5RE-binding protein 1
HUB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303481.3NP_001290410.1  zinc finger protein 282 isoform 2

    See identical proteins and their annotated locations for NP_001290410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004890, AK316282, BC041704, BC073805, D30612
    Consensus CDS
    CCDS78284.1
    UniProtKB/Swiss-Prot
    Q9UDV7
    UniProtKB/TrEMBL
    Q86YG2
    Related
    ENSP00000418840.1, ENST00000479907.1
    Conserved Domains (1) summary
    smart00349
    Location:198260
    KRAB; krueppel associated box
  2. NM_003575.4NP_003566.1  zinc finger protein 282 isoform 1

    See identical proteins and their annotated locations for NP_003566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC041704, BC073805, D30612
    Consensus CDS
    CCDS5895.1
    UniProtKB/Swiss-Prot
    Q9UDV7
    UniProtKB/TrEMBL
    A0A090N8Y3, Q86YG2
    Related
    ENSP00000477841.1, ENST00000610704.5
    Conserved Domains (6) summary
    cd07765
    Location:198237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:198260
    KRAB; krueppel associated box
    COG5048
    Location:506651
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:548568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:574596
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:616641
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    149195495..149226243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716151.4XP_006716214.1  zinc finger protein 282 isoform X1

    Conserved Domains (6) summary
    cd07765
    Location:198237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:198260
    KRAB; krueppel associated box
    COG5048
    Location:507652
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:549569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:575597
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:617642
    zf-H2C2_2; Zinc-finger double domain
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