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Zfp282 zinc finger protein 282 [ Mus musculus (house mouse) ]

Gene ID: 101095, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp282provided by MGI
Official Full Name
zinc finger protein 282provided by MGI
Primary source
MGI:MGI:2141413
See related
Ensembl:ENSMUSG00000025821 AllianceGenome:MGI:2141413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HUB1; E430019K09Rik
Summary
Predicted to enable sequence-specific double-stranded DNA binding activity. Is expressed in 1st branchial arch maxillary component; early conceptus; genitourinary system; and limb. Orthologous to human ZNF282 (zinc finger protein 282). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 8.4), CNS E18 (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp282 in Genome Data Viewer
Location:
6 B2.3; 6 22.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47853433..47885419)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47877209..47908485)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_15785 Neighboring gene zinc finger protein 786 Neighboring gene zinc finger protein 398 Neighboring gene predicted gene, 52899 Neighboring gene Zinc finger protein 212 Neighboring gene STARR-positive B cell enhancer ABC_E8099 Neighboring gene zinc finger protein 783 Neighboring gene zinc finger protein 956

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A pathogenic AKAP4 variant, p.R429H, causes male in/subfertility in humans and mice. Wei H, et al. Clin Transl Med, 2023 Dec. PMID 38050179, Free PMC Article
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC36603

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 282

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146175.3 → NP_666287.3  zinc finger protein 282

    Status: VALIDATED

    Source sequence(s)
    AC166248, AK030516, AK030919, AK148038, BX524317, BY129988
    Consensus CDS
    CCDS20100.1
    UniProtKB/TrEMBL
    E9PVC2, Q8R3D4
    Related
    ENSMUSP00000053643.7, ENSMUST00000061890.8
    Conserved Domains (6) summary
    smart00349
    Location:198 → 260
    KRAB; krueppel associated box
    COG5048
    Location:568 → 621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:544 → 564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:570 → 592
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:198 → 237
    KRAB; KRAB box
    pfam13465
    Location:612 → 637
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    47853433..47885419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241099.4 → XP_011239401.1  zinc finger protein 282 isoform X1

    UniProtKB/TrEMBL
    Q8R3D4
    Conserved Domains (5) summary
    smart00349
    Location:198 → 260
    KRAB; krueppel associated box
    sd00017
    Location:516 → 536
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:514 → 536
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:112 → 168
    DUF3669; Zinc finger protein
    pfam13465
    Location:528 → 553
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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