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SLC25A11 solute carrier family 25 member 11 [ Homo sapiens (human) ]

Gene ID: 8402, updated on 27-Jun-2020

Summary

Official Symbol
SLC25A11provided by HGNC
Official Full Name
solute carrier family 25 member 11provided by HGNC
Primary source
HGNC:HGNC:10981
See related
Ensembl:ENSG00000108528 MIM:604165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OGC; PGL6; SLC20A4
Summary
The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]
Expression
Ubiquitous expression in heart (RPKM 61.1), kidney (RPKM 32.4) and 24 other tissues See more
Orthologs

Genomic context

See SLC25A11 in Genome Data Viewer
Location:
17p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4937130..4940251, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4840425..4843462, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene ring finger protein 167 Neighboring gene profilin 1 Neighboring gene enolase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxaloacetate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
alpha-ketoglutarate transport IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
 
malate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitochondrial 2-oxoglutarate/malate carrier protein
Names
OGCP
solute carrier family 20 (oxoglutarate carrier), member 4
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165417.1NP_001158889.1  mitochondrial 2-oxoglutarate/malate carrier protein isoform 2

    See identical proteins and their annotated locations for NP_001158889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA937945, AK290376, BM047391, CB155476
    UniProtKB/TrEMBL
    Q6IBH0
    Related
    ENSP00000458993.1, ENST00000576951.1
    Conserved Domains (1) summary
    pfam00153
    Location:105202
    Mito_carr; Mitochondrial carrier protein
  2. NM_001165418.1NP_001158890.1  mitochondrial 2-oxoglutarate/malate carrier protein isoform 3

    See identical proteins and their annotated locations for NP_001158890.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA937945, AK290376, BI752999, CB155476
    Consensus CDS
    CCDS54069.1
    UniProtKB/TrEMBL
    Q6IBH0
    Related
    ENSP00000440804.2, ENST00000544061.6
    Conserved Domains (1) summary
    pfam00153
    Location:65162
    Mito_carr; Mitochondrial carrier protein
  3. NM_003562.5NP_003553.2  mitochondrial 2-oxoglutarate/malate carrier protein isoform 1

    See identical proteins and their annotated locations for NP_003553.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA937945, AK290376, CB155476
    Consensus CDS
    CCDS11059.1
    UniProtKB/Swiss-Prot
    Q02978
    UniProtKB/TrEMBL
    Q6IBH0
    Related
    ENSP00000225665.7, ENST00000225665.12
    Conserved Domains (1) summary
    pfam00153
    Location:24102
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4937130..4940251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450994.1XP_024306762.1  mitochondrial 2-oxoglutarate/malate carrier protein isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:144241
    Mito_carr; Mitochondrial carrier protein
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