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Slc25a11 solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 [ Mus musculus (house mouse) ]

Gene ID: 67863, updated on 8-Jan-2023

Summary

Official Symbol
Slc25a11provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11provided by MGI
Primary source
MGI:MGI:1915113
See related
Ensembl:ENSMUSG00000014606 AllianceGenome:MGI:1915113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2oxoc; 2310022P18Rik
Summary
Predicted to enable antiporter activity; dicarboxylic acid transmembrane transporter activity; and sulfur compound transmembrane transporter activity. Predicted to be involved in anion transport. Located in mitochondrial inner membrane. Is expressed in embryo. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SLC25A11 (solute carrier family 25 member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 208.5), kidney adult (RPKM 85.6) and 27 other tissues See more
Orthologs
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Genomic context

See Slc25a11 in Genome Data Viewer
Location:
11 B3; 11 43.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70534845..70538356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70644019..70647531, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12315 Neighboring gene glycoprotein 1b, alpha polypeptide Neighboring gene ring finger protein 167 Neighboring gene profilin 1 Neighboring gene enolase 3, beta muscle Neighboring gene sperm associated antigen 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-ketoglutarate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables malate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxaloacetate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxoglutarate:malate antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxoglutarate:malate antiporter activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables succinate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in malate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oxaloacetate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in succinate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in thiosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitochondrial 2-oxoglutarate/malate carrier protein
Names
OGCP
alpha-oxoglutarate carrier
solute carrier family 25 member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024211.3NP_077173.1  mitochondrial 2-oxoglutarate/malate carrier protein

    See identical proteins and their annotated locations for NP_077173.1

    Status: VALIDATED

    Source sequence(s)
    AI196845, AI931249, AK009487, BY006289
    Consensus CDS
    CCDS24958.1
    UniProtKB/Swiss-Prot
    Q9CR62
    UniProtKB/TrEMBL
    A0A6P5QKA2, A0A8C6GE97, Q5SX53
    Related
    ENSMUSP00000014750.9, ENSMUST00000014750.15
    Conserved Domains (1) summary
    pfam00153
    Location:24102
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70534845..70538356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534026.3XP_006534089.1  mitochondrial 2-oxoglutarate/malate carrier protein isoform X1

    See identical proteins and their annotated locations for XP_006534089.1

    Conserved Domains (1) summary
    pfam00153
    Location:186277
    Mito_carr; Mitochondrial carrier protein