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ATAD3B ATPase family AAA domain containing 3B [ Homo sapiens (human) ]

Gene ID: 83858, updated on 5-Sep-2021

Summary

Official Symbol
ATAD3Bprovided by HGNC
Official Full Name
ATPase family AAA domain containing 3Bprovided by HGNC
Primary source
HGNC:HGNC:24007
See related
Ensembl:ENSG00000160072 MIM:612317
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOB3; AAA-TOB3
Summary
The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 7.4), testis (RPKM 6.3) and 25 other tissues See more
Orthologs
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Genomic context

See ATAD3B in Genome Data Viewer
Location:
1p36.33
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1471732..1509466)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1407145..1433228)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 1 Neighboring gene ATPase family AAA domain containing 3C Neighboring gene ATPase family AAA domain containing 3A Neighboring gene transmembrane protein 240

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATPase family, AAA domain containing 3B (ATAD3B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1273

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ATPase family AAA domain-containing protein 3B
Names
AAA-ATPase TOB3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317238.2NP_001304167.1  ATPase family AAA domain-containing protein 3B isoform AAA-TOB3s precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (AAA-TOB3s) has a shorter and distinct N-terminus compared to isoform AAA-TOB3l.
    Source sequence(s)
    AL157945, AL645728, BC009938
    UniProtKB/Swiss-Prot
    Q5T9A4
    Related
    ENST00000472194.6
    Conserved Domains (2) summary
    pfam00004
    Location:302429
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam12037
    Location:49240
    DUF3523; Domain of unknown function (DUF3523)
  2. NM_031921.6NP_114127.3  ATPase family AAA domain-containing protein 3B isoform AAA-TOB3l

    See identical proteins and their annotated locations for NP_114127.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (AAA-TOB3l).
    Source sequence(s)
    AK290586, AL645728, BC009938
    Consensus CDS
    CCDS30.1
    UniProtKB/Swiss-Prot
    Q5T9A4
    Related
    ENSP00000500094.1, ENST00000673477.1
    Conserved Domains (5) summary
    TIGR01242
    Location:198556
    26Sp45; 26S proteasome subunit P45 family
    pfam00004
    Location:348475
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam12037
    Location:42286
    DUF3523; Domain of unknown function (DUF3523)
    cd16269
    Location:151162
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:94179
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1471732..1509466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244806.3XP_005244863.1  ATPase family AAA domain-containing protein 3B isoform X1

    Conserved Domains (3) summary
    TIGR01242
    Location:198564
    26Sp45; 26S proteasome subunit P45 family
    pfam00004
    Location:348475
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam12037
    Location:42286
    DUF3523; Domain of unknown function (DUF3523)
  2. XM_011542244.1XP_011540546.1  ATPase family AAA domain-containing protein 3B isoform X3

    Conserved Domains (5) summary
    TIGR01242
    Location:246604
    26Sp45; 26S proteasome subunit P45 family
    pfam00004
    Location:396523
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam12037
    Location:42334
    DUF3523; Domain of unknown function (DUF3523)
    cd16269
    Location:199210
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:142227
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. XM_011542241.3XP_011540543.1  ATPase family AAA domain-containing protein 3B isoform X2

    See identical proteins and their annotated locations for XP_011540543.1

    Conserved Domains (4) summary
    pfam00004
    Location:348450
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam12037
    Location:42286
    DUF3523; Domain of unknown function (DUF3523)
    cd16269
    Location:151162
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:94179
    GBP_C; Guanylate-binding protein, C-terminal domain

RNA

  1. XR_001737468.1 RNA Sequence

  2. XR_946776.2 RNA Sequence

    Related
    ENST00000308647.8
  3. XR_002957738.1 RNA Sequence

  4. XR_241045.2 RNA Sequence

  5. XR_001737470.1 RNA Sequence

  6. XR_001737469.1 RNA Sequence

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