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FIP1L1 factor interacting with PAPOLA and CPSF1 [ Homo sapiens (human) ]

Gene ID: 81608, updated on 23-Nov-2021

Summary

Official Symbol
FIP1L1provided by HGNC
Official Full Name
factor interacting with PAPOLA and CPSF1provided by HGNC
Primary source
HGNC:HGNC:19124
See related
Ensembl:ENSG00000145216 MIM:607686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rhe; FIP1; hFip1
Summary
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in testis (RPKM 13.3), brain (RPKM 11.1) and 25 other tissues See more
Orthologs
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Genomic context

See FIP1L1 in Genome Data Viewer
Location:
4q12
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (53377641..53462583)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (54243808..54327029)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sec1 family domain containing 2 Neighboring gene VISTA enhancer hs1460 Neighboring gene RNA, U6 small nuclear 310, pseudogene Neighboring gene uncharacterized LOC105377654 Neighboring gene LNX1 antisense RNA 1 Neighboring gene ligand of numb-protein X 1 Neighboring gene COMM domain containing 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
GeneReviews: Not available
Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33619, DKFZp586K0717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
contributes_to RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pre-mRNA cleavage required for polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
pre-mRNA 3'-end-processing factor FIP1
Names
FIP1 like 1
FIP1-like 1 protein
FIP1L1 cleavage and polyadenylation specific factor subunit
factor interacting with PAP
rearranged in hypereosinophilia

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008644.1 RefSeqGene

    Range
    4989..88210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134937.2NP_001128409.1  pre-mRNA 3'-end-processing factor FIP1 isoform 2

    See identical proteins and their annotated locations for NP_001128409.1

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS47055.1
    UniProtKB/Swiss-Prot
    Q6UN15
    Related
    ENSP00000351383.5, ENST00000358575.9
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  2. NM_001134938.2NP_001128410.1  pre-mRNA 3'-end-processing factor FIP1 isoform 3

    See identical proteins and their annotated locations for NP_001128410.1

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Consensus CDS
    CCDS47056.1
    UniProtKB/Swiss-Prot
    Q6UN15
    Related
    ENSP00000302993.6, ENST00000306932.10
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  3. NM_001376744.1NP_001363673.1  pre-mRNA 3'-end-processing factor FIP1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  4. NM_001376745.1NP_001363674.1  pre-mRNA 3'-end-processing factor FIP1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  5. NM_001376746.1NP_001363675.1  pre-mRNA 3'-end-processing factor FIP1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  6. NM_001376747.1NP_001363676.1  pre-mRNA 3'-end-processing factor FIP1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  7. NM_001376748.1NP_001363677.1  pre-mRNA 3'-end-processing factor FIP1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  8. NM_001376749.1NP_001363678.1  pre-mRNA 3'-end-processing factor FIP1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  9. NM_001376750.1NP_001363679.1  pre-mRNA 3'-end-processing factor FIP1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  10. NM_001376751.1NP_001363680.1  pre-mRNA 3'-end-processing factor FIP1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  11. NM_001376752.1NP_001363681.1  pre-mRNA 3'-end-processing factor FIP1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  12. NM_001376753.1NP_001363682.1  pre-mRNA 3'-end-processing factor FIP1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  13. NM_001376754.1NP_001363683.1  pre-mRNA 3'-end-processing factor FIP1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  14. NM_001376755.1NP_001363684.1  pre-mRNA 3'-end-processing factor FIP1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:153195
    Fip1; Fip1 motif
  15. NM_001376756.1NP_001363685.1  pre-mRNA 3'-end-processing factor FIP1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  16. NM_001376757.1NP_001363686.1  pre-mRNA 3'-end-processing factor FIP1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  17. NM_001376758.1NP_001363687.1  pre-mRNA 3'-end-processing factor FIP1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  18. NM_001376759.1NP_001363688.1  pre-mRNA 3'-end-processing factor FIP1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  19. NM_001376760.1NP_001363689.1  pre-mRNA 3'-end-processing factor FIP1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  20. NM_001376761.1NP_001363690.1  pre-mRNA 3'-end-processing factor FIP1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  21. NM_001376762.1NP_001363691.1  pre-mRNA 3'-end-processing factor FIP1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  22. NM_001376764.1NP_001363693.1  pre-mRNA 3'-end-processing factor FIP1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  23. NM_001376765.1NP_001363694.1  pre-mRNA 3'-end-processing factor FIP1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  24. NM_001376766.1NP_001363695.1  pre-mRNA 3'-end-processing factor FIP1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  25. NM_001376767.1NP_001363696.1  pre-mRNA 3'-end-processing factor FIP1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  26. NM_001376768.1NP_001363697.1  pre-mRNA 3'-end-processing factor FIP1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  27. NM_001376769.1NP_001363698.1  pre-mRNA 3'-end-processing factor FIP1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  28. NM_001376770.1NP_001363699.1  pre-mRNA 3'-end-processing factor FIP1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  29. NM_001376771.1NP_001363700.1  pre-mRNA 3'-end-processing factor FIP1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  30. NM_001376772.1NP_001363701.1  pre-mRNA 3'-end-processing factor FIP1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:133160
    Fip1; Fip1 motif
  31. NM_001376773.1NP_001363702.1  pre-mRNA 3'-end-processing factor FIP1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  32. NM_001376774.1NP_001363703.1  pre-mRNA 3'-end-processing factor FIP1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  33. NM_001376775.1NP_001363704.1  pre-mRNA 3'-end-processing factor FIP1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  34. NM_001376776.1NP_001363705.1  pre-mRNA 3'-end-processing factor FIP1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  35. NM_001376777.1NP_001363706.1  pre-mRNA 3'-end-processing factor FIP1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  36. NM_001376778.1NP_001363707.1  pre-mRNA 3'-end-processing factor FIP1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  37. NM_001376779.1NP_001363708.1  pre-mRNA 3'-end-processing factor FIP1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  38. NM_001376780.1NP_001363709.1  pre-mRNA 3'-end-processing factor FIP1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  39. NM_001376781.1NP_001363710.1  pre-mRNA 3'-end-processing factor FIP1 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  40. NM_001376782.1NP_001363711.1  pre-mRNA 3'-end-processing factor FIP1 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:115157
    Fip1; Fip1 motif
  41. NM_001376783.1NP_001363712.1  pre-mRNA 3'-end-processing factor FIP1 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  42. NM_001376784.1NP_001363713.1  pre-mRNA 3'-end-processing factor FIP1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:139181
    Fip1; Fip1 motif
  43. NM_001376785.1NP_001363714.1  pre-mRNA 3'-end-processing factor FIP1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
  44. NM_001376786.1NP_001363715.1  pre-mRNA 3'-end-processing factor FIP1 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  45. NM_030917.4NP_112179.2  pre-mRNA 3'-end-processing factor FIP1 isoform 1

    See identical proteins and their annotated locations for NP_112179.2

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821, AY366510, DN990103
    Consensus CDS
    CCDS3491.1
    UniProtKB/Swiss-Prot
    Q6UN15
    Related
    ENSP00000336752.6, ENST00000337488.11
    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif

RNA

  1. NR_164847.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
  2. NR_164848.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821
  3. NR_164849.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC058822, AC098821

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    53377641..53462583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265779.4XP_005265836.1  pre-mRNA 3'-end-processing factor FIP1 isoform X11

    Conserved Domains (1) summary
    pfam05182
    Location:154196
    Fip1; Fip1 motif
  2. XM_017008670.1XP_016864159.1  pre-mRNA 3'-end-processing factor FIP1 isoform X16

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