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CAMK2B calcium/calmodulin dependent protein kinase II beta [ Homo sapiens (human) ]

Gene ID: 816, updated on 26-Sep-2020

Summary

Official Symbol
CAMK2Bprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II betaprovided by HGNC
Primary source
HGNC:HGNC:1461
See related
Ensembl:ENSG00000058404 MIM:607707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta
Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues See more
Orthologs

Genomic context

See CAMK2B in Genome Data Viewer
Location:
7p13
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44217154..44326167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44256749..44365230, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375257 Neighboring gene glucokinase Neighboring gene YKT6 v-SNARE homolog Neighboring gene NudC domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 3634 Neighboring gene ribosomal protein L32 pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
GeneReviews: Not available
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
GeneReviews: Not available
Intellectual disability, autosomal dominant 54
MedGen: C4540484 OMIM: 617799 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2018-06-28)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated (2018-06-28)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces CAK2B Thr-287 phosphorylation in mature and immature oligodendrocytes in vitro PubMed
tat HIV-1 Tat activates CAMK2B in both mature and immature oligodendrocytes in vitro PubMed
tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29528

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of dendritic spine development TAS
Traceable Author Statement
more info
PubMed 
regulation of long-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of skeletal muscle adaptation TAS
Traceable Author Statement
more info
PubMed 
regulation of synapse structural plasticity TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
calcium- and calmodulin-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit beta
Names
CaM kinase II beta subunit
CaM-kinase II beta chain
caMK-II subunit beta
proline rich calmodulin-dependent protein kinase
NP_001211.3
NP_001280099.1
NP_742075.1
NP_742076.1
NP_742077.1
NP_742078.1
NP_742079.1
NP_742080.1
NP_742081.1
XP_005249919.1
XP_005249921.1
XP_006715844.1
XP_006715847.1
XP_011513849.1
XP_011513851.1
XP_011513852.1
XP_011513853.1
XP_011513854.1
XP_011513855.1
XP_011513856.1
XP_011513857.1
XP_011513858.1
XP_011513859.1
XP_011513860.1
XP_011513861.1
XP_016868149.1
XP_016868150.1
XP_016868151.1
XP_016868152.1
XP_016868153.1
XP_016868154.1
XP_016868155.1
XP_016868156.1
XP_016868157.1
XP_016868158.1
XP_016868159.1
XP_024302713.1
XP_024302714.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029407.1 RefSeqGene

    Range
    5038..113478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001220.5NP_001211.3  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

    See identical proteins and their annotated locations for NP_001211.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC006454, AK290148, BI550751, U23460
    Consensus CDS
    CCDS5483.1
    UniProtKB/Swiss-Prot
    Q13554
    UniProtKB/TrEMBL
    A4D2J9
    Related
    ENSP00000379098.2, ENST00000395749.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:534661
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001293170.2NP_001280099.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001280099.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks multiple alternate in-frame exons in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Variants 2 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    AF078803, AK290148, AK294138, BI550751, BQ130578
    Consensus CDS
    CCDS5484.1
    UniProtKB/Swiss-Prot
    Q13554
    UniProtKB/TrEMBL
    B7Z1Z6
    Related
    ENSP00000326375.5, ENST00000350811.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_172078.3NP_742075.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_742075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2) that is missing an internal segment compared to isoform 1. Variants 2 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    AC006454, AF078803, AK290148, BI550751
    Consensus CDS
    CCDS5484.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000397937.2, ENST00000440254.6
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. NM_172079.3NP_742076.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

    See identical proteins and their annotated locations for NP_742076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as beta 4, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), also known as beta 4 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AJ252238, AK290148, BI550751, BX445032, DB566810
    Consensus CDS
    CCDS5485.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000390292.1, ENST00000457475.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. NM_172080.3NP_742077.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4

    See identical proteins and their annotated locations for NP_742077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as beta e, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (4), also known as beta e subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF083419, AK290148, BI550751
    Consensus CDS
    CCDS43573.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000258682.6, ENST00000258682.10
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:385512
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  6. NM_172081.3NP_742078.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5

    See identical proteins and their annotated locations for NP_742078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as beta e', lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (5), also known as beta e' subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AK290148, BC019070
    Consensus CDS
    CCDS5486.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000351542.3, ENST00000358707.7
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. NM_172082.3NP_742079.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6

    See identical proteins and their annotated locations for NP_742079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as beta 6, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (6), also known as beta 6 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF081924, AK290148, BI550751
    Consensus CDS
    CCDS5487.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000326544.6, ENST00000347193.8
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    cl09109
    Location:386487
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
  8. NM_172083.3NP_742080.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7

    See identical proteins and their annotated locations for NP_742080.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as beta 2, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (7), also known as beta 2 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AA399393, AC006454, AJ252236, AK290148, BI550751, DA069361, DB175099
    Consensus CDS
    CCDS5488.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000326427.5, ENST00000353625.8
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:347474
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  9. NM_172084.3NP_742081.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8

    See identical proteins and their annotated locations for NP_742081.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as beta 7, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (8), also known as beta 7 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AK290148, BI550751, BX445032, DB566810
    Consensus CDS
    CCDS5489.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000326518.5, ENST00000346990.8
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:317444
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44217154..44326167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446946.1XP_024302714.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X27

    Conserved Domains (2) summary
    pfam08332
    Location:256383
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017012670.2XP_016868159.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X28

  3. XM_017012668.2XP_016868157.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X25

    Conserved Domains (3) summary
    smart00220
    Location:1143
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:257384
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017012669.2XP_016868158.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X26

    Conserved Domains (2) summary
    pfam08332
    Location:257384
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017012663.2XP_016868152.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17

  6. XM_017012667.2XP_016868156.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X24

    Conserved Domains (2) summary
    pfam08332
    Location:266393
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017012666.2XP_016868155.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X23

    Conserved Domains (2) summary
    pfam08332
    Location:281408
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011515559.2XP_011513861.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16

    See identical proteins and their annotated locations for XP_011513861.1

    Conserved Domains (3) summary
    smart00220
    Location:1143
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:448575
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  9. XM_017012665.1XP_016868154.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X22

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:361488
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  10. XM_011515557.1XP_011513859.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:528655
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  11. XM_017012664.1XP_016868153.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:370497
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  12. XM_006715781.2XP_006715844.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X29

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:494621
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  13. XM_011515554.1XP_011513856.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:537664
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  14. XM_017012662.1XP_016868151.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15

  15. XM_011515552.1XP_011513854.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:552679
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  16. XM_005249864.3XP_005249921.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21

    See identical proteins and their annotated locations for XP_005249921.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:362489
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  17. XM_011515556.1XP_011513858.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:529656
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  18. XM_017012660.1XP_016868149.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7

  19. XM_011515550.1XP_011513852.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:553680
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  20. XM_006715784.2XP_006715847.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19

    See identical proteins and their annotated locations for XP_006715847.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  21. XM_011515551.1XP_011513853.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:553680
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  22. XM_005249862.3XP_005249919.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18

    See identical proteins and their annotated locations for XP_005249919.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:395522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  23. XM_017012661.1XP_016868150.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12

  24. XM_011515549.1XP_011513851.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:562689
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  25. XM_024446945.1XP_024302713.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:496623
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  26. XM_011515553.1XP_011513855.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:539666
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  27. XM_011515555.1XP_011513857.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:534661
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  28. XM_011515547.1XP_011513849.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011513849.1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:577704
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  29. XM_011515558.2XP_011513860.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14

    Conserved Domains (2) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
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