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CAMK2B calcium/calmodulin dependent protein kinase II beta [ Homo sapiens (human) ]

Gene ID: 816, updated on 6-Jul-2026
Official Symbol
CAMK2Bprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II betaprovided by HGNC
Primary source
HGNC:HGNC:1461
See related
Ensembl:ENSG00000058404 MIM:607707; AllianceGenome:HGNC:1461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAM2; CAMK2; CAMKB; MRD54; CaMKIIbeta
Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CAMK2B in Genome Data Viewer
Location:
7p13
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44217154..44326013, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44375741..44485432, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44256753..44365193, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44223563-44224100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44224101-44224636 Neighboring gene glucokinase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44253740-44254655 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44257065-44257612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44257613-44258158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44260592-44261156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44261157-44261720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44275325-44276208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25933 Neighboring gene YKT6 vesicular SNARE protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44289329-44289847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44301759-44302258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44302657-44303488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44303489-44304320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44307709-44308208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44307207-44307708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44311666-44312166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44322903-44323685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44328206-44328848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44329545-44330046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44333819-44334319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44348485-44349088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44349089-44349690 Neighboring gene uncharacterized LOC124901621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44389311-44389811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25940 Neighboring gene NudC domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 3634 Neighboring gene ribosomal protein L32 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18144 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44532074-44532200 Neighboring gene RNA, U6 small nuclear 1097, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Alternative splicing generates a CaM kinase IIbeta isoform in myocardium that targets the sarcoplasmic reticulum through a putative alphaKAP and regulates GAPDH. Singh P, et al. Mol Cell Biochem, 2005 Feb. PMID 15792370
  2. Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities. Wang P, et al. FEBS Lett, 2000 Jun 16. PMID 10858498
  3. Identification and validation of candidate risk genes in endocytic vesicular trafficking associated with esophageal atresia and tracheoesophageal fistulas. Zhong G, et al. HGG Adv, 2022 Jul 14. PMID 35519826, Free PMC Article
  4. Calcium/calmodulin-dependent protein kinase II regulation of I(Ks) during sustained β-adrenergic receptor stimulation. Shugg T, et al. Heart Rhythm, 2018 Jun. PMID 29410121, Free PMC Article
  5. Clinical exome sequencing of 1000 families with complex immune phenotypes: Toward comprehensive genomic evaluations. Similuk MN, et al. J Allergy Clin Immunol, 2022 Oct. PMID 35753512, Free PMC Article

See all (133) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.
    Title: Understanding the pathogenetic mechanisms underlying altered neuronal function associated with CAMK2B mutations.
  2. Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
    Title: Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
  3. CaMKIIbeta in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.
    Title: CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases.
  4. CaMKII regulates KCNQ1 at S484 during sustained beta-AR stimulation to inhibit IKs. The ability of CaMKII to inhibit IKs may contribute to arrhythmogenicity during HF.
    Title: Calcium/calmodulin-dependent protein kinase II regulation of I(Ks) during sustained β-adrenergic receptor stimulation.
  5. The importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function.
    Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.
  6. TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1.
    Title: Ca(2+)/calmodulin-dependent protein kinase IIβ and IIδ mediate TGFβ-induced transduction of fibronectin and collagen in human pulmonary fibroblasts.
  7. Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control.
    Title: Possible inhibitor from traditional Chinese medicine for the β form of calcium-dependent protein kinase type II in the treatment of major depressive disorder.
  8. beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells
    Title: β-carotene reverses the IL-1β-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells.
  9. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
    Title: Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
  10. Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines.
    Title: Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual disability, autosomal dominant 54
MedGen: C4540484 OMIM: 617799 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2023-01-25)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2023-01-25)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
EBI GWAS Catalog
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces CAK2B Thr-287 phosphorylation in mature and immature oligodendrocytes in vitro PubMed
tat HIV-1 Tat activates CAMK2B in both mature and immature oligodendrocytes in vitro PubMed
tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC29528

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term synaptic potentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of calcium ion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of dendritic spine development TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of long-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of skeletal muscle adaptation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of synapse structural plasticity TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcium- and calmodulin-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of calcium- and calmodulin-dependent protein kinase complex IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit beta
Names
CaM kinase II beta subunit
CaM-kinase II beta chain
caMK-II subunit beta
proline rich calmodulin-dependent protein kinase
NP_001211.3
NP_001280099.1
NP_742075.1
NP_742076.1
NP_742077.1
NP_742078.1
NP_742079.1
NP_742080.1
NP_742081.1
XP_005249919.1
XP_005249921.1
XP_006715844.1
XP_006715847.1
XP_011513849.1
XP_011513851.1
XP_011513852.1
XP_011513853.1
XP_011513854.1
XP_011513855.1
XP_011513856.1
XP_011513857.1
XP_011513858.1
XP_011513859.1
XP_011513860.1
XP_011513861.1
XP_016868149.1
XP_016868150.1
XP_016868151.1
XP_016868153.1
XP_016868154.1
XP_024302713.1
XP_047276836.1
XP_047276837.1
XP_047276838.1
XP_047276839.1
XP_054215063.1
XP_054215064.1
XP_054215065.1
XP_054215066.1
XP_054215067.1
XP_054215068.1
XP_054215069.1
XP_054215070.1
XP_054215071.1
XP_054215072.1
XP_054215073.1
XP_054215074.1
XP_054215075.1
XP_054215076.1
XP_054215077.1
XP_054215078.1
XP_054215079.1
XP_054215080.1
XP_054215081.1
XP_054215082.1
XP_054215083.1
XP_054215084.1
XP_054215085.1
XP_054215086.1
XP_054215087.1
XP_054215088.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029407.1 RefSeqGene

    Range
    5038..113478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001220.5 → NP_001211.3  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

    See identical proteins and their annotated locations for NP_001211.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC006454, AK290148, BI550751, U23460
    Consensus CDS
    CCDS5483.1
    UniProtKB/Swiss-Prot
    A4D2K0, A4D2K1, A4D2K2, A4D2K3, A4D2K4, A4D2K5, A4D2K6, O95437, O95438, O95599, Q13554, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4
    UniProtKB/TrEMBL
    A0ACI8UBC5
    Related
    ENSP00000379098.2, ENST00000395749.7
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:534 → 661
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. NM_001293170.2 → NP_001280099.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001280099.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks multiple alternate in-frame exons in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Variants 2 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    AF078803, AK290148, AK294138, BI550751, BQ130578
    Consensus CDS
    CCDS5484.1
    UniProtKB/TrEMBL
    Q53H78
    Related
    ENSP00000326375.5, ENST00000350811.7
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410 → 537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  3. NM_172078.3 → NP_742075.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_742075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2) that is missing an internal segment compared to isoform 1. Variants 2 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    AC006454, AF078803, AK290148, BI550751
    Consensus CDS
    CCDS5484.1
    UniProtKB/TrEMBL
    Q53H78
    Related
    ENSP00000397937.2, ENST00000440254.6
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410 → 537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  4. NM_172079.3 → NP_742076.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

    See identical proteins and their annotated locations for NP_742076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as beta 4, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), also known as beta 4 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AJ252238, AK290148, BI550751, BX445032, DB566810
    Consensus CDS
    CCDS5485.1
    UniProtKB/TrEMBL
    Q53H78
    Related
    ENSP00000379096.2, ENST00000395747.6
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386 → 513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  5. NM_172080.3 → NP_742077.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4

    See identical proteins and their annotated locations for NP_742077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as beta e, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (4), also known as beta e subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF083419, AK290148, BI550751
    Consensus CDS
    CCDS43573.1
    UniProtKB/TrEMBL
    Q53H78
    Related
    ENSP00000258682.6, ENST00000258682.10
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:385 → 512
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  6. NM_172081.3 → NP_742078.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5

    See identical proteins and their annotated locations for NP_742078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as beta e', lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (5), also known as beta e' subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AK290148, BC019070
    Consensus CDS
    CCDS5486.1
    UniProtKB/TrEMBL
    A0ACI8S828
    Related
    ENSP00000351542.3, ENST00000358707.7
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371 → 498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  7. NM_172082.3 → NP_742079.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6

    See identical proteins and their annotated locations for NP_742079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as beta 6, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (6), also known as beta 6 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF081924, AK290148, BI550751
    Consensus CDS
    CCDS5487.1
    UniProtKB/TrEMBL
    A0ACI8RSG5
    Related
    ENSP00000326544.6, ENST00000347193.8
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    cl09109
    Location:386 → 487
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

  8. NM_172083.3 → NP_742080.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7

    See identical proteins and their annotated locations for NP_742080.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as beta 2, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (7), also known as beta 2 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AA399393, AC006454, AJ252236, AK290148, BI550751, DA069361, DB175099
    Consensus CDS
    CCDS5488.1
    UniProtKB/TrEMBL
    A0ACI8UAT0
    Related
    ENSP00000326427.5, ENST00000353625.8
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:347 → 474
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  9. NM_172084.3 → NP_742081.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8

    See identical proteins and their annotated locations for NP_742081.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as beta 7, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (8), also known as beta 7 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AK290148, BI550751, BX445032, DB566810
    Consensus CDS
    CCDS5489.1
    UniProtKB/TrEMBL
    A0ACI8UAT0
    Related
    ENSP00000326518.5, ENST00000346990.8
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:317 → 444
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    44217154..44326013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515559.3 → XP_011513861.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19

    See identical proteins and their annotated locations for XP_011513861.1

    UniProtKB/TrEMBL
    A0ACI8UB62
    Conserved Domains (3) summary
    smart00220
    Location:1 → 143
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:448 → 575
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1 → 174
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017012665.2 → XP_016868154.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X24

    UniProtKB/TrEMBL
    A0ACI8UAJ6, A0ACI8UAT0
    Related
    ENSP00000613397.1, ENST00000943338.1
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:361 → 488
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  3. XM_011515557.2 → XP_011513859.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

    UniProtKB/TrEMBL
    A0ACI8QLD4, A0ACI8RXU1
    Related
    ENSP00000566883.1, ENST00000896824.1
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:528 → 655
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  4. XM_017012664.2 → XP_016868153.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X22

    UniProtKB/TrEMBL
    A0ACI8S828, A0ACI8S9I3
    Related
    ENSP00000566891.1, ENST00000896832.1
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:370 → 497
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  5. XM_006715781.3 → XP_006715844.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X26

    UniProtKB/TrEMBL
    A0ACI8U7Z3, A0ACI8UBJ1
    Related
    ENSP00000613371.1, ENST00000943312.1
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:494 → 621
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  6. XM_011515554.2 → XP_011513856.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

    UniProtKB/TrEMBL
    A0ACI8RXU1
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:537 → 664
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  7. XM_017012662.2 → XP_016868151.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17

    UniProtKB/TrEMBL
    A0ACI8QYJ0, A0ACI8UB78
    Related
    ENSP00000566877.1, ENST00000896818.1

  8. XM_011515552.2 → XP_011513854.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5

    UniProtKB/TrEMBL
    A0ACI8QPA7, A0ACI8RXU1
    Related
    ENSP00000566881.1, ENST00000896822.1
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:552 → 679
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  9. XM_005249864.4 → XP_005249921.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X23

    See identical proteins and their annotated locations for XP_005249921.1

    UniProtKB/TrEMBL
    A0ACI8RUM5, A0ACI8UAT0
    Related
    ENSP00000566899.1, ENST00000896840.1
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:362 → 489
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  10. XM_011515556.2 → XP_011513858.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

    UniProtKB/TrEMBL
    A0ACI8RXU1
    Related
    ENSP00000613407.1, ENST00000943348.1
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:529 → 656
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  11. XM_047420882.1 → XP_047276838.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18

    UniProtKB/TrEMBL
    A0ACI8R5W9, A0ACI8RAG8
    Related
    ENSP00000566888.1, ENST00000896829.1

  12. XM_047420881.1 → XP_047276837.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15

    UniProtKB/TrEMBL
    A0ACI8SEC2, A0ACI8U7Z3
    Related
    ENSP00000566880.1, ENST00000896821.1

  13. XM_017012660.2 → XP_016868149.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7

    UniProtKB/TrEMBL
    A0ACI8RIY3, A0ACI8RXU1
    Related
    ENSP00000566904.1, ENST00000896845.1

  14. XM_047420880.1 → XP_047276836.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13

    UniProtKB/TrEMBL
    A0ACI8QLD5, A0ACI8U7Z3
    Related
    ENSP00000566882.1, ENST00000896823.1

  15. XM_011515550.2 → XP_011513852.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

    UniProtKB/TrEMBL
    A0ACI8RXU1, A0ACI8U7Y8
    Related
    ENSP00000613382.1, ENST00000943323.1
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:553 → 680
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  16. XM_006715784.3 → XP_006715847.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21

    See identical proteins and their annotated locations for XP_006715847.1

    UniProtKB/TrEMBL
    A0ACI8UAT0
    Related
    ENSP00000613406.1, ENST00000943347.1
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386 → 513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  17. XM_011515551.2 → XP_011513853.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

    UniProtKB/TrEMBL
    A0ACI8UB62
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:553 → 680
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  18. XM_005249862.4 → XP_005249919.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20

    See identical proteins and their annotated locations for XP_005249919.1

    UniProtKB/TrEMBL
    Q53H78
    Related
    ENSP00000566896.1, ENST00000896837.1
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:395 → 522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  19. XM_017012661.2 → XP_016868150.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12

    UniProtKB/TrEMBL
    A0ACI8U814
    Related
    ENSP00000566900.1, ENST00000896841.1

  20. XM_011515549.2 → XP_011513851.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

    UniProtKB/TrEMBL
    A0ACI8UB62
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:562 → 689
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  21. XM_024446945.2 → XP_024302713.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14

    UniProtKB/TrEMBL
    A0ACI8U7X5, A0ACI8UBB0
    Related
    ENSP00000613372.1, ENST00000943313.1
    Conserved Domains (2) summary
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:496 → 623
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  22. XM_011515553.2 → XP_011513855.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

    UniProtKB/TrEMBL
    A0ACI8U814, A0ACI8U870
    Related
    ENSP00000613408.1, ENST00000943349.1
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:539 → 666
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  23. XM_011515555.2 → XP_011513857.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

    UniProtKB/TrEMBL
    A0ACI8U814
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:534 → 661
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  24. XM_011515547.2 → XP_011513849.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011513849.1

    UniProtKB/TrEMBL
    A0ACI8U818, A0ACI8UB62
    Related
    ENSP00000613383.1, ENST00000943324.1
    Conserved Domains (3) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:577 → 704
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  25. XM_047420883.1 → XP_047276839.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X25

    UniProtKB/TrEMBL
    A0A8V8TQ13
    Related
    ENSP00000514922.1, ENST00000700291.1

  26. XM_011515558.3 → XP_011513860.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16

    UniProtKB/TrEMBL
    A0ACI8UB62
    Conserved Domains (2) summary
    smart00220
    Location:14 → 272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12 → 303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    44375741..44485432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359106.1 → XP_054215081.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19

    UniProtKB/TrEMBL
    A0ACI8UB62

  2. XM_054359111.1 → XP_054215086.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X24

    UniProtKB/TrEMBL
    A0ACI8UAJ6, A0ACI8UAT0

  3. XM_054359098.1 → XP_054215073.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

    UniProtKB/TrEMBL
    A0ACI8QLD4, A0ACI8RXU1

  4. XM_054359109.1 → XP_054215084.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X22

    UniProtKB/TrEMBL
    A0ACI8S828, A0ACI8S9I3

  5. XM_054359113.1 → XP_054215088.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X26

    UniProtKB/TrEMBL
    A0ACI8U7Z3, A0ACI8UBJ1

  6. XM_054359095.1 → XP_054215070.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

    UniProtKB/TrEMBL
    A0ACI8RXU1

  7. XM_054359104.1 → XP_054215079.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17

    UniProtKB/TrEMBL
    A0ACI8QYJ0, A0ACI8UB78

  8. XM_054359092.1 → XP_054215067.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5

    UniProtKB/TrEMBL
    A0ACI8QPA7, A0ACI8RXU1

  9. XM_054359110.1 → XP_054215085.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X23

    UniProtKB/TrEMBL
    A0ACI8RUM5, A0ACI8UAT0

  10. XM_054359097.1 → XP_054215072.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

    UniProtKB/TrEMBL
    A0ACI8RXU1

  11. XM_054359105.1 → XP_054215080.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18

    UniProtKB/TrEMBL
    A0ACI8R5W9, A0ACI8RAG8

  12. XM_054359102.1 → XP_054215077.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15

    UniProtKB/TrEMBL
    A0ACI8SEC2, A0ACI8U7Z3

  13. XM_054359094.1 → XP_054215069.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7

    UniProtKB/TrEMBL
    A0ACI8RIY3, A0ACI8RXU1

  14. XM_054359100.1 → XP_054215075.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13

    UniProtKB/TrEMBL
    A0ACI8QLD5, A0ACI8U7Z3

  15. XM_054359090.1 → XP_054215065.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

    UniProtKB/TrEMBL
    A0ACI8RXU1, A0ACI8U7Y8

  16. XM_054359108.1 → XP_054215083.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21

    UniProtKB/TrEMBL
    A0ACI8UAT0

  17. XM_054359091.1 → XP_054215066.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

    UniProtKB/TrEMBL
    A0ACI8UB62

  18. XM_054359107.1 → XP_054215082.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20

    UniProtKB/TrEMBL
    Q53H78

  19. XM_054359099.1 → XP_054215074.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12

    UniProtKB/TrEMBL
    A0ACI8U814

  20. XM_054359089.1 → XP_054215064.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

    UniProtKB/TrEMBL
    A0ACI8UB62

  21. XM_054359101.1 → XP_054215076.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14

    UniProtKB/TrEMBL
    A0ACI8U7X5, A0ACI8UBB0

  22. XM_054359093.1 → XP_054215068.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

    UniProtKB/TrEMBL
    A0ACI8U814, A0ACI8U870

  23. XM_054359096.1 → XP_054215071.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

    UniProtKB/TrEMBL
    A0ACI8U814

  24. XM_054359088.1 → XP_054215063.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

    UniProtKB/TrEMBL
    A0ACI8U818, A0ACI8UB62

  25. XM_054359112.1 → XP_054215087.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X25

    UniProtKB/TrEMBL
    A0A8V8TQ13

  26. XM_054359103.1 → XP_054215078.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16

    UniProtKB/TrEMBL
    A0ACI8UB62
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13554.3 GenPept UniProtKB/Swiss-Prot:Q13554

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