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CAMK2B calcium/calmodulin dependent protein kinase II beta [ Homo sapiens (human) ]

Gene ID: 816, updated on 12-Aug-2018

Summary

Official Symbol
CAMK2Bprovided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase II betaprovided by HGNC
Primary source
HGNC:HGNC:1461
See related
Ensembl:ENSG00000058404 MIM:607707; Vega:OTTHUMG00000023491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAM2; CAMK2; CAMKB; MRD54
Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Biased expression in brain (RPKM 44.0), heart (RPKM 16.4) and 2 other tissues See more
Orthologs

Genomic context

See CAMK2B in Genome Data Viewer
Location:
7p13
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (44217150..44326167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44256749..44365230, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375257 Neighboring gene glucokinase Neighboring gene YKT6 v-SNARE homolog Neighboring gene NudC domain containing 3 Neighboring gene ribosomal protein L32 pseudogene 18 Neighboring gene RNA, U6 small nuclear 1097, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
MENTAL RETARDATION, AUTOSOMAL DOMINANT 54
MedGen: C4540484 OMIM: 617799 GeneReviews: Not available
not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2018-06-28)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated (2018-06-28)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
NHGRI GWA Catalog
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces CAK2B Thr-287 phosphorylation in mature and immature oligodendrocytes in vitro PubMed
tat HIV-1 Tat activates CAMK2B in both mature and immature oligodendrocytes in vitro PubMed
tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via LFA-1 in NK cells, providing evidence that Tat inhibits NK cell activation which might contribute to the impairment of natural immunity in HIV-1 infection PubMed
tat HIV-1 Tat inhibits the activation of CAMKII elicited via beta (3) integrin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • ARMS-mediated activation, organism-specific biosystem (from REACTOME)
    ARMS-mediated activation, organism-specific biosystemARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which ...
  • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
    Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Aldosterone synthesis and secretion, organism-specific biosystem (from KEGG)
    Aldosterone synthesis and secretion, organism-specific biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Aldosterone synthesis and secretion, conserved biosystem (from KEGG)
    Aldosterone synthesis and secretion, conserved biosystemAldosterone is a steroid hormone synthesized in and secreted from the outer layer of the adrenal cortex, the zona glomerulosa. Aldosterone plays an important role in the regulation of systemic blood ...
  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • CREB phosphorylation through the activation of CaMKII, organism-specific biosystem (from REACTOME)
    CREB phosphorylation through the activation of CaMKII, organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase signal transduction, leading to the activation of PKA and phosphorylation and activation of CREB-in...
  • CREB phosphorylation through the activation of Ras, organism-specific biosystem (from REACTOME)
    CREB phosphorylation through the activation of Ras, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Cholinergic synapse, organism-specific biosystem (from KEGG)
    Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • DAP12 signaling, organism-specific biosystem (from REACTOME)
    DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Downstream signal transduction, organism-specific biosystem (from REACTOME)
    Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
    FCERI mediated MAPK activation, organism-specific biosystemFormation of the LAT signaling complex leads to activation of MAPK and production of cytokines. The sequence of events that leads from LAT to cytokine production has not been as clearly defined as th...
  • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
    Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
  • Frs2-mediated activation, organism-specific biosystem (from REACTOME)
    Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
  • GRB2 events in EGFR signaling, organism-specific biosystem (from REACTOME)
    GRB2 events in EGFR signaling, organism-specific biosystemAutophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through i...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Glioma, organism-specific biosystem (from KEGG)
    Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
  • Glioma, conserved biosystem (from KEGG)
    Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
  • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
    Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon signaling pathway, conserved biosystem (from KEGG)
    Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • HSF1-dependent transactivation, organism-specific biosystem (from REACTOME)
    HSF1-dependent transactivation, organism-specific biosystemAcquisition of DNA binding activity by HSF1 is necessary but insufficient for transcriptional activation (Cotto JJ et al. 1996; Trinklein ND et al. 2004). In addition to having a sequence-specific DN...
  • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
    IFN-gamma pathway, organism-specific biosystem
    IFN-gamma pathway
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
    Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
  • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
    Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Ion homeostasis, organism-specific biosystem (from REACTOME)
    Ion homeostasis, organism-specific biosystemIon channel homeostasis in relation to cardiac conduction is described in this section (Couette et al. 2006, Bartos et al. 2015).
  • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
    Ion transport by P-type ATPases, organism-specific biosystemThe P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catal...
  • Long-term potentiation, organism-specific biosystem (from KEGG)
    Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
  • Long-term potentiation, conserved biosystem (from KEGG)
    Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
    MAPK1/MAPK3 signaling, organism-specific biosystemThe extracellular signal regulated kinases (ERKs) 1 and 2, also known as MAPK3 and MAPK1, are phosphorylated by the MAP2Ks 1 and 2 in response to a wide range of extracellular stimuli to promote diff...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Olfactory transduction, organism-specific biosystem (from KEGG)
    Olfactory transduction, organism-specific biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Olfactory transduction, conserved biosystem (from KEGG)
    Olfactory transduction, conserved biosystemWithin the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be tra...
  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Phase 0 - rapid depolarisation, organism-specific biosystem (from REACTOME)
    Phase 0 - rapid depolarisation, organism-specific biosystemPhase 0 is the rapid depolarisation phase in which electrical stimulation of a cell initiates events involving the influx and efflux of ions resulting in the production of a cell's action potential. ...
  • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
    Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
  • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
    Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
  • Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
    Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
    RAF/MAP kinase cascade, organism-specific biosystemThe RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to growth factors, hormones and cytokines, among others. Bin...
  • RET signaling, organism-specific biosystem (from REACTOME)
    RET signaling, organism-specific biosystemThe RET proto-oncogene encodes a receptor tyrosine kinase expressed primarily in urogenital precursor cells, spermatogonocytes, dopaminergic neurons, motor neurons and neural crest progenitors and de...
  • Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystem (from REACTOME)
    Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystemCa2+ influx through the NMDA receptor leads to the activation of Ras kinase via the activation of RasGRF.
  • SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
    SHC1 events in EGFR signaling, organism-specific biosystemGRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation.
  • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
    SOS-mediated signalling, organism-specific biosystemSOS is recruited to the plasma membrane and mediates activation of Ras.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling by Leptin, organism-specific biosystem (from REACTOME)
    Signaling by Leptin, organism-specific biosystemLeptin (LEP, OB, OBS), a circulating adipokine, and its receptor LEPR (DB, OBR) control food intake and energy balance and are implicated in obesity-related diseases (recently reviewed in Amitani et ...
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
    Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Signalling to ERKs, organism-specific biosystem (from REACTOME)
    Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
  • Signalling to RAS, organism-specific biosystem (from REACTOME)
    Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
  • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
    Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
  • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
    Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    p38 MAPK signaling pathway, organism-specific biosystem
    p38 MAPK signaling pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29528

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Ras guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
actin binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of dendritic spine development TAS
Traceable Author Statement
more info
PubMed 
regulation of long-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of skeletal muscle adaptation TAS
Traceable Author Statement
more info
PubMed 
regulation of synapse structural plasticity TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit beta
Names
CaM kinase II beta subunit
CaM-kinase II beta chain
caMK-II subunit beta
proline rich calmodulin-dependent protein kinase
NP_001211.3
NP_001280099.1
NP_742075.1
NP_742076.1
NP_742077.1
NP_742078.1
NP_742079.1
NP_742080.1
NP_742081.1
XP_005249919.1
XP_005249921.1
XP_006715844.1
XP_006715847.1
XP_011513849.1
XP_011513851.1
XP_011513852.1
XP_011513853.1
XP_011513854.1
XP_011513855.1
XP_011513856.1
XP_011513857.1
XP_011513858.1
XP_011513859.1
XP_011513860.1
XP_011513861.1
XP_016868149.1
XP_016868150.1
XP_016868151.1
XP_016868152.1
XP_016868153.1
XP_016868154.1
XP_016868155.1
XP_016868156.1
XP_016868157.1
XP_016868158.1
XP_016868159.1
XP_024302713.1
XP_024302714.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029407.1 RefSeqGene

    Range
    5001..113482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001220.4NP_001211.3  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

    See identical proteins and their annotated locations for NP_001211.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC006454, AK290148, BI550751, U23460
    Consensus CDS
    CCDS5483.1
    UniProtKB/Swiss-Prot
    Q13554
    UniProtKB/TrEMBL
    A4D2J9
    Related
    ENSP00000379098.2, OTTHUMP00000159355, ENST00000395749.6, OTTHUMT00000251138
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:534661
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001293170.1NP_001280099.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001280099.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks multiple alternate in-frame exons in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Variants 2 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    AF078803, AK290148, AK294138, BI550751, BQ130578
    Consensus CDS
    CCDS5484.1
    UniProtKB/Swiss-Prot
    Q13554
    UniProtKB/TrEMBL
    B7Z1Z6
    Related
    ENSP00000326375.5, OTTHUMP00000209343, ENST00000350811.7, OTTHUMT00000343339
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_172078.2NP_742075.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_742075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (2) that is missing an internal segment compared to isoform 1. Variants 2 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    AC006454, AF078803, AK290148, BI550751
    Consensus CDS
    CCDS5484.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000397937.2, OTTHUMP00000025109, ENST00000440254.6, OTTHUMT00000059812
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. NM_172079.2NP_742076.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

    See identical proteins and their annotated locations for NP_742076.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as beta 4, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), also known as beta 4 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AJ252238, AK290148, BI550751, BX445032, DB566810
    Consensus CDS
    CCDS5485.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000390292.1, ENST00000457475.5
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. NM_172080.2NP_742077.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 4

    See identical proteins and their annotated locations for NP_742077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as beta e, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (4), also known as beta e subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF083419, AK290148, BI550751
    Consensus CDS
    CCDS43573.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000258682.6, OTTHUMP00000225913, ENST00000258682.10, OTTHUMT00000377323
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:385512
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  6. NM_172081.2NP_742078.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 5

    See identical proteins and their annotated locations for NP_742078.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as beta e', lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (5), also known as beta e' subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AK290148, BC019070, BI550751
    Consensus CDS
    CCDS5486.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000351542.3, OTTHUMP00000159440, ENST00000358707.7, OTTHUMT00000251229
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. NM_172082.2NP_742079.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 6

    See identical proteins and their annotated locations for NP_742079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as beta 6, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (6), also known as beta 6 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AF081924, AK290148, BI550751
    Consensus CDS
    CCDS5487.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000326544.6, OTTHUMP00000159441, ENST00000347193.8, OTTHUMT00000251230
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    cl09109
    Location:386487
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
  8. NM_172083.2NP_742080.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 7

    See identical proteins and their annotated locations for NP_742080.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as beta 2, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (7), also known as beta 2 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AA399393, AC006454, AJ252236, AK290148, BI550751, DA069361, DB175099
    Consensus CDS
    CCDS5488.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000326427.5, OTTHUMP00000159442, ENST00000353625.8, OTTHUMT00000251231
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:347474
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  9. NM_172084.2NP_742081.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 8

    See identical proteins and their annotated locations for NP_742081.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as beta 7, lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (8), also known as beta 7 subunit, that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AC006454, AK290148, BI550751, BX445032, DB566810
    Consensus CDS
    CCDS5489.1
    UniProtKB/Swiss-Prot
    Q13554
    Related
    ENSP00000326518.5, OTTHUMP00000159443, ENST00000346990.8, OTTHUMT00000251232
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:317444
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    44217150..44326167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446946.1XP_024302714.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X27

    Conserved Domains (2) summary
    pfam08332
    Location:256383
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017012670.2XP_016868159.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X28

  3. XM_017012668.2XP_016868157.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X25

    Conserved Domains (3) summary
    smart00220
    Location:1143
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:257384
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017012669.2XP_016868158.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X26

    Conserved Domains (2) summary
    pfam08332
    Location:257384
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017012663.2XP_016868152.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17

  6. XM_017012667.2XP_016868156.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X24

    Conserved Domains (2) summary
    pfam08332
    Location:266393
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  7. XM_017012666.2XP_016868155.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X23

    Conserved Domains (3) summary
    smart00220
    Location:1143
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:281408
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011515559.2XP_011513861.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16

    See identical proteins and their annotated locations for XP_011513861.1

    Conserved Domains (3) summary
    smart00220
    Location:1143
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam08332
    Location:448575
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    cl21453
    Location:1174
    PKc_like; Protein Kinases, catalytic domain
  9. XM_017012665.1XP_016868154.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X22

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:361488
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  10. XM_011515557.1XP_011513859.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:528655
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  11. XM_017012664.1XP_016868153.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:370497
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  12. XM_006715781.2XP_006715844.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X29

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:494621
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  13. XM_011515554.1XP_011513856.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:537664
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  14. XM_017012662.1XP_016868151.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15

  15. XM_011515552.1XP_011513854.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:552679
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  16. XM_005249864.3XP_005249921.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21

    See identical proteins and their annotated locations for XP_005249921.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:362489
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  17. XM_011515556.1XP_011513858.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:529656
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  18. XM_017012660.1XP_016868149.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7

  19. XM_011515550.1XP_011513852.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:553680
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  20. XM_006715784.2XP_006715847.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19

    See identical proteins and their annotated locations for XP_006715847.1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  21. XM_011515551.1XP_011513853.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:553680
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  22. XM_005249862.3XP_005249919.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18

    See identical proteins and their annotated locations for XP_005249919.1

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:395522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  23. XM_017012661.1XP_016868150.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12

  24. XM_011515549.1XP_011513851.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:562689
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  25. XM_024446945.1XP_024302713.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:496623
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  26. XM_011515553.1XP_011513855.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:539666
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  27. XM_011515555.1XP_011513857.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:534661
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  28. XM_011515547.1XP_011513849.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011513849.1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:577704
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  29. XM_011515558.2XP_011513860.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14

    Conserved Domains (2) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
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